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BACKGROUNDJapan faces rapid population aging, resulting in significant health challenges such as sarcopenia and frailty, which affect the independence and quality of life of older adults. This study evaluated the effectiveness of Aomori gymnastics, a culturally tailored exercise program, in improving physical function in older women with sarcopenia, over a three-month period.METHODSThis prospective observational study included 24 older women divided into three groups based on their living conditions: community-dwelling participants attending preventive care programs (Groups 1 and 2) and residents of a long-term care facility (Group 3). The participants performed Aomori gymnastics daily for three months. Physical function was assessed at baseline, 1 month, and three months using the Short Physical Performance Battery (SPPB), grip strength, curl-ups, forward bend from a long sitting position, one-leg stance, and 10-m walk tests. Data were analyzed using generalized linear mixed models and the Mann-Whitney U test.RESULTSSignificant improvements in SPPB scores were observed between the sarcopenia and non-sarcopenia groups at baseline and one month (p < .05), these differences were not observed at three months. Participants with sarcopenia showed marked improvement in physical function, approaching the level of those without sarcopenia after three months of daily exercise. Adherence was higher among long-term care facility residents than among community-dwelling participants, which is likely due to the severe winter weather in the Aomori Prefecture.CONCLUSIONAomori gymnastics is an effective and low-cost intervention that can significantly improve physical function in older women with sarcopenia. Implementing this program in communities and care facilities can enhance the quality of life and independence of older adults, particularly in regions with harsh weather conditions.

01 Feb 2025·Immunology Letters

Th1 adjuvant ARNAX, in combination with radiation therapy, enhances tumor regression in mouse tumor-implant models

Article

Author: Seya, Tsukasa ; Takeda, Yohei ; Yoshida, Sumito ; Miyazaki, Aya ; Tomaru, Utano ; Matsumoto, Misako

Radiation therapy (RT) rarely induces tumor regression at untreated metastatic sites, the so-called abscopal effect. A syngeneic tumor (EG7) transplanted into a Th1-dominant mouse strain (C57BL/6) regressed significantly on the treated side and less on the contralateral side after RT. Additional subcutaneous administration of ARNAX, a non-inflammatory adjuvant, further accelerated tumor regression on the untreated side. This suggests that ARNAX after RT significantly enhances the tumor regression effect on the irrelevant tumor. Based on this setting, we next observed similar tumor shrinkage after RT and ARNAX by transplanting syngeneic breast cancer tumors (4T1) into a Th2-dominant mouse strain (BALB/c). The results were as follows: 1. ARNAX enhanced RT-mediated tumor shrinkage comparable to polyI:C; 2. In the Th2 mouse strain, little tumor regression occurred on the untreated side compared to tumor regression on the treated side after RT alone; 3. RT+ARNAX treatment caused additive regression on the treated side and induced slight tumor regression on the untreated side; 4. PD-L1 antibody + RT combination therapy caused tumor regression and further induced additive regression with ARNAX; 5. The combination of RT and ARNAX reduced the number and volume of lung metastases compared to RT alone. However, tumor regression was not always accompanied by a significant prolongation of survival in the mice receiving our regimen and protocol (one 10Gy radiation and a single ARNAX treatment). In conclusion, RT therapy promoted abscopal tumor regression in both Th2 and Th1 models with the addition of the non-inflammatory adjuvant ARNAX.

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Pipeline

Pipeline Snapshot as of 20 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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