[Translation] A single-center, randomized, double-blind, parallel-controlled, dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics of YKRH00020 inhalation solution in healthy subjects
1)评价健康受试者单次、多次给予YKRH00020吸入溶液的安全性和耐受性,确定最大耐受剂量(MTD),为II期临床试验提供合适的给药剂量(RP2D)。
2)评价YKRH00020吸入溶液单次、多次给药在健康受试者体内的药代动力学特征。
[Translation] 1) Evaluate the safety and tolerability of single and multiple administrations of YKRH00020 inhalation solution to healthy subjects, determine the maximum tolerated dose (MTD), and provide a suitable administration dose (RP2D) for Phase II clinical trials.
2) Evaluate the pharmacokinetic characteristics of single and multiple administrations of YKRH00020 inhalation solution in healthy subjects.