Delving into the Latest Updates on Aphoenix, Inc. with Synapse

Overview

Methotrexate (MTX) is the anticancer and antirheumatoid drug that is believed to block nucleotide synthesis and cell cycle by inhibiting dihydrofolate reductase activity. We have developed novel affinity matrices, termed SG beads, that are easy to manipulate and are compatible with surface functionalization. Using the matrices, here we present evidence that deoxycytidine kinase (dCK), an enzyme that acts in the salvage pathway of nucleotide biosynthesis, is another target of MTX. MTX modulates dCK activity differentially depending on substrate concentrations. 1-beta-D-Arabinofuranosylcytosine (ara-C), a chemotherapy agent often used in combination with MTX, is a nucleoside analog whose incorporation into chromosome requires prior phosphorylation by dCK. We show that, remarkably, MTX enhances incorporation and cytotoxicity of ara-C through regulation of dCK activity in Burkitt's lymphoma cells. Thus, this study provides new insight into the mechanisms underlying MTX actions and demonstrates the usefulness of the SG beads.

01 Jan 2004·Drug Delivery System

ナノテクノロジーによる薬物レセプター探索

Author: Mamoru Hatakeyama ; Yasuaki Kabe ; Hiroshi Handa

Drug Delivery System

Screening of drug target receptor by using nanotechnology

Author: Handa, Hiroshi ; Hatakeyama, Mamoru ; Kabe, Yasuaki

A review, discussing drug discovery by screening of drug target receptors using nanotechnol. and affinity beads.

100 Deals associated with Aphoenix, Inc.

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100 Translational Medicine associated with Aphoenix, Inc.

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Pipeline

Pipeline Snapshot as of 18 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Reverse targeting technologies(Roche/Aphoenix)	-	Discontinued
Respiratory disease therapy(Aphoenix) ( Cytokines x NF-κB x chloride channel )	Pulmonary Disease, Chronic Obstructive More	Pending
AFX-300 series (Aphoenix)	Inflammatory Bowel Diseases More	Pending
AFX-200 series (Aphoenix) ( Cytokine receptors x RANK )	Osteoporosis More	Pending