JiShou University

Endocrine disrupting compounds (EDCs) extensively distributed in the environment have imposed severe hazards on ecological systems and human health owing to their persistence, bioaccumulation, and toxicity. Herein, a capillary fluorescence imprinted microarray sensor integrated with intelligent logic gate was constructed to achieve the rapid visual identification and quantification of three EDCs involving dibutyl phthalate (DBP), bisphenol A (BPA), triphenyl phosphate (TPHP), and their mixtures. Three molecularly imprinted polymers were respectively controllably modified onto a capillary inner surface with static gas-driven coating approach to obtain a golden-hoop-type microarray sensor, generating specific fluorescence responses and distinguishable color variations toward the three target EDCs. By integrating fluorescence sensing with one-step image analysis, the capillary fluorescence microarray sensor achieved a rapid response toward DBP, BPA, and TPHP within 3.5 min, with favorable sensitivities of 0.65, 7.2, and 4.6 nM, respectively. Furthermore, this capillary fluorescence microarray sensor successfully recognized DBP, BPA and TPHP in spiked biological and food matrices. The proposed multi-segment microarray sensing strategy combined with intelligent logic gates achieves the improvement in anti-interference ability, detection intelligence and practicability, providing a promising strategy for the on-site simultaneous rapid detection of multiple EDCs with a microvolume (50 μL/time) in real samples.

Substance use disorders (SUDs) remain a severe global public health challenge. Non-pharmacological interventions are widely used to improve mental health and quality of life (QoL) in people with SUDs, but their comparative effectiveness for these outcomes remains uncertain.

To compare the relative efficacy of non-pharmacological interventions for anxiety, depression, and QoL in individuals with SUDs.

Two reviewers independently screened studies and extracted data. We conducted a random-effects frequentist network meta-analysis and prioritized the earliest post-intervention assessment to improve comparability across trials.

We included 117 RCTs from 25 countries (11,177 participants). Compared with a pooled control condition, several interventions showed reductions in anxiety symptoms, including neuromodulation, combined intervention, mind-body therapy, relapse prevention, and acupuncture. For depression, favorable estimates were observed for neuromodulation, conventional exercise, cognitive behavioral therapy, mind-body therapy, and acupuncture. For QoL, evidence did not show a reliable benefit at the earliest post-intervention time point; estimates were imprecise (e.g., mind-body therapy vs control). SUCRA rankings identified neuromodulation as the top-ranked option for both anxiety and QoL, with mind-body therapy ranking highest for depression. Subgroup analyses indicated that the relative effects of interventions may vary according to country development level and intervention duration.

Several non-pharmacological interventions were associated with short-term improvements in anxiety and depressive symptoms in people with SUDs, while short-term QoL effects were uncertain. Comparative rankings should be interpreted cautiously given imprecision, heterogeneity, and sparse head-to-head evidence and should be integrated with feasibility, patient preferences, and local service capacity.

https://www.crd.york.ac.uk/PROSPERO, identifier CRD420251265848.

With the rapid and widespread emergence of antibiotic-resistant bacteria, the development of novel and highly effective antibacterial strategies has become an urgent imperative. Graphene oxide‑silver nanoparticle composites (GOAg) represent a class of promising inorganic nano-antibacterial materials. However, GOAg rapidly undergoes aggregation in saline- or protein-containing physiological media, which severely hampers its antibacterial applications. Therefore, identifying an appropriate carrier for GOAg immobilization is urgently needed. In this study, a carboxymethyl chitosan-aldehyde sodium alginate (CMCS-ASA) hydrogel was employed as a matrix to encapsulate GOAg, thereby fabricating a CMCS-ASA-GOAg composite hydrogel. Comprehensive characterization demonstrated that the resulting composite hydrogel exhibited favorable swelling capacity, water-retention ability, injectability, self-healing performance, and optical transparency. Moreover, the hydrogel showed high drug encapsulation efficiency, appreciable loading capacity, and sustained-release behavior, enabling the continuous release of Ag⁺ for up to 27 days. The CMCS-ASA-GOAg composite hydrogel also exhibited excellent antibacterial activity and satisfactory biocompatibility. When the GOAg concentration reached 40 μg/mL, both the surface and interior of the hydrogel achieved bactericidal efficiencies exceeding 95% against Gram-negative and Gram-positive bacteria, while showing no obvious cytotoxicity toward mouse embryonic fibroblast cells. Collectively, these findings provide a new strategy and valuable reference for expanding the antibacterial applications of graphene-based nanomaterials.