Delving into the Latest Updates on Guangzhou Baiyunshan Qixing Pharmaceutical Co., Ltd. with Synapse

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Nervous System Diseases

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Herbal medicine

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Introduction. Positive effects have been observed when the traditional Chinese medicine Hua Tuo Zai Zao Wan (HTZZW) has been used for the treatment of atherosclerosis (AS), although with an unclear mechanism. Methods. ApoE-/- C57/BALB mice were used to determine the efficacy of HTZZW by blood lipid biochemical analysis and histopathology H&E staining. qPCR and western blot were used to determine the expression of METTL3/14 and NF-κB. Results. High-fat diet-fed ApoE-/- mice that consumed HTZZW exhibited significantly smaller plaque areas and significantly decreased unstable collagen areas in the aortic arch as well as significantly lower blood levels of total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol compared with the control group. Consumption of HTZZW significantly decreased the proportion of Mφ1 in the peripheral blood. HTZZW not only inhibited the expression of m6A methyltransferases METTL14, METTL3, and overall RNA methylation level, but it also decreased the m6A modification level on specific sites of NF-κB mRNA. Conclusion. HTZZW significantly alleviated the progression of AS by regulating the expression of the m6A methyltransferases METTL14 and METTL3 in macrophages, eliminating m6A modifications of NF-κB mRNA, influencing the stability of NF-κB mRNA, and ultimately resulting in the deactivation of inflammatory macrophages.

01 Dec 2018·BMC NeurologyQ4 · MEDICINE

Association between socioeconomic status and post-stroke functional outcome in deprived rural southern China: a population-based study

Q4 · MEDICINE

ArticleOA

Author: Dang, Ge ; Zhao, Yuhui ; Zhang, Chunbo ; Chen, Yicong ; Ouyang, Fubing ; Zeng, Jinsheng ; Wang, Ying ; Huang, Weixian ; Lin, Yang

BACKGROUNDData on the association between socioeconomic status and post-stroke functional outcome in developing countries is lacking. We aimed to evaluate the association in stroke survivors in deprived rural Southern China.METHODSWe conducted door-to-door interviews and collected data using a structured questionnaire in stroke survivors from five fourth-class rural areas of Guangdong Province through a non-government initiated registry from August 2014 to March 2015. Descriptive statistics were used to provide information on the demographic, socioeconomic and clinical characteristics of the selected population. Univariate and multivariate logistic regression were used to examine the relationship of socioeconomic status indexed by self-reported average family income and functional impairment defined as a modified Rankin Scale of 3 to 5.RESULTSAmong the 425 stroke survivors, 52.7% lived below the poverty line set by the local government. About 50% of patients suffered from functional impairment and required assistance in their daily life. Compared with their wealthier counterpart, stroke survivors with lower income were more likely to have functional impairment (OR 2.85, 95% CI 1.93-4.23). The effect size increased and remained significant after adjusting for possible confounding factors (OR 3.17, 95% CI 2.04-4.91).CONCLUSIONSPoorer patients tend to have poorer post-stroke functional outcome. Primary and secondary strategies targeting underprivileged populations in less-developed areas are thus urgently needed in China.

Guangdong Yaoxueyuan Xuebao

Detection of menthol in Zhikebipa granules by capillary gas chromatography

Author: Tan, Zaiyou ; Cao, Yanfang ; Liu, Shengbo ; Zeng, Yunyun ; Jian, Liuqing

The separation of samples was performed on a column of Wax-10 capillary column (0.32 mm × 30 m × 0.25 μm).The column temperature was 110°, sample temperature was 250°, detector temperature was 250°; FID detector.The calibration curve was linear in the range of 0.0517-0.6683 mg/mL for menthol (r = 1.0000).The average recovery was 101.1% (RSD = 2.0%, n = 6).The method is simple and feasible and the established criteria is suitable for the detection of menthol.

100 Deals associated with Guangzhou Baiyunshan Qixing Pharmaceutical Co., Ltd.

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100 Translational Medicine associated with Guangzhou Baiyunshan Qixing Pharmaceutical Co., Ltd.

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Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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