Medulloblastoma (MB), a rare yet critical pediatric brain tumor, is divided into 4 molecular subgroups (WNT, SHH, Group 3, Group 4), each with distinct genetic profiles. Despite diagnostic and therapeutic advances, neurotoxicity from standard treatments (resection, radiotherapy, chemotherapy) and the need for long-term care remain challenges. CDK4/6 inhibitors (palbociclib, ribociclib, abemaciclib), approved for breast cancer, show potential in other tumors, but their efficacy in MB is unclear. Treatment resistance is a concern. This project aims to identify genetic markers of sensitivity to CDK4/6 inhibitors in MB, to improve therapies and overcome resistance.

Start Date25 Nov 2024

Sponsor / Collaborator

Azienda Ospedaliera Villa Sofia CTO

[+2]

NCT04663971

/ RecruitingNot ApplicableIIT

IBD Audit on Fertility, Pregnancy and Delivery in Patients With Inflammatory Bowel Disease: a International Study

Crohn's disease and Ulcerative colitis are chronic disease that are usually diagnosed at young age. The diseases and the associated treatment can impact on patient's sexual function, fertility, pregnancy, and delivery. This study aims to assess the impact of inflammatory bowel diseases on these aspects in female patients.

Start Date01 Feb 2024

Sponsor / Collaborator

University of Campania Luigi Vanvitelli

[+2]

100 Clinical Results associated with Università degli Studi di Roma Tor Vergata

0 Patents (Medical) associated with Università degli Studi di Roma Tor Vergata

16,338

Literatures (Medical) associated with Università degli Studi di Roma Tor Vergata

30 Jan 2026·ARCHIVES OF CLINICAL NEUROPSYCHOLOGY

Abnormal Forgetting Rate from the Recency Portion of a Word-List in Patients with Subjective Cognitive Decline

Article

Author: Leonardi, C ; Pugliese, M ; Caruso, G ; Stanzione, A ; De Simone, M S ; Di Palma, V ; Carlesimo, G A ; Covino, S ; Rodini, M ; Caltagirone, C

Abstract:

Background:

Subjective cognitive decline (SCD) is a self-perceived decline in cognitive functioning, considered at risk for Mild Cognitive Impairment (MCI) and Alzheimer’s Disease (AD).

Objective:

In this retrospective case-control study, we investigated whether the Recency ratio (Rr), a measure of forgetting from the final portion of a word list, can objectify the memory complaints reported by individuals with SCD.

Method:

We administered the 15-word list Recall Test to 54 SCD individuals and 69 healthy controls. Both groups disclosed a recency effect in immediate recall, with a decline in the delayed recall, particularly marked in the SCD group.

Results:

A two-way ANOVA comparing ratio scores across the three portions of the list revealed a significant Group x Position interaction (F = 4.47; p = .01), due to a significantly higher ratio value in the recency portion for the SCD group (F = 4.84; p = .03), while primacy and mid-list ratios were comparable between groups.

Conclusions:

These results, in continuity with previous data in MCI and AD populations, may suggest that, since Rr significantly differs between groups, a possible model including Rr along with other measures may increase accuracy in detecting memory complaints experienced by SCD people. Even if Rr alone cannot predict group classification, our observations could help identify neuropsychological markers useful in the early stages of AD. To our knowledge, this is the first time Rr has been studied in the SCD population, and this makes our data particularly relevant, in that they document a decline that standard neuropsychological tests are not able to detect.

01 Jan 2026·ANNALS OF VASCULAR SURGERY

E-STABILISE Technique: A Solution for Postdissection Thoracic Aortic Aneurysm Repair: The Association of Transcatheter Electosurgical Septotomy with the STABILISE Technique

Article

Author: Ippoliti, Arnaldo ; Fresilli, Mauro ; Di Girolamo, Alessia ; Oddi, Fabio Massimo ; Martelli, Eugenio

BACKGROUND:

Postdissection thoracic aortic aneurysm (PD-TAA) treatment represents one of the most challenging scenarios in vascular surgery, and has led to the development of various techniques. This is a retrospective single-center study aiming to show the early results of patients affected by PD-TAA treated by Transcatheter Electrosurgical Septotomy, followed by endovascular remodeling using the STent-Assisted Balloon-Induced intimaL dISruption and rElamination (STABILISE) in aortic dissection repair technique.

METHODS:

From January 2023 to December 2024, 10 patients were treated for PD-TAA using this technique. Aneurysmal degeneration involved both the aortic arch and thoracic aorta in 6 cases, while in the remaining 4 cases, only the descending thoracic aorta was involved. After endovascular repair of the aortic arch, when needed, and electrosurgical septotomy of the dissection lamella in the thoraco-abdominal tract, the procedure was completed by thoracic graft and dissection aortic stent placement, followed by aortic ballooning, performed in the same fashion as the STABILISE technique.

RESULTS:

Technical success and clinical success were achieved in 100% of cases. No intraoperative and 24-h death and aorta-related complications were recorded. No 30-day mortality was recorded. No aorta-related complication at 30 days was recorded in 9 cases. In one case, a type IB endoleak was recorded and was treated with a branched thoraco-abdominal endograft.

CONCLUSION:

These preliminary results suggest that the combination of the Transcatheter Electrosurgical Septotomy (TES) with the STABILISE technique is promising in a selected cohort of patients. Further studies are necessary to confirm these results.

01 Jan 2026·European Stroke Journal

Association between door-to-needle time and outcomes in acute ischemic stroke patients treated with intravenous thrombolysis plus mechanical thrombectomy: Analysis from the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS)

Article

Author: Galvano, Gianluca ; Cioni, Samuele ; Boghi, Andrea ; Boero, Giovanni ; D’Agostino, Federica ; Naldi, Andrea ; Lafe, Elvis ; Vinci, Sergio Lucio ; Alemseged, Fana ; Diomedi, Marina ; Petruzzellis, Marco ; Gallesio, Ivan ; Giossi, Alessia ; Ciacciarelli, Antonio ; Toni, Danilo ; Cappellari, Manuel ; Mascolo, Alfredo Paolo ; Cavasin, Nicola ; De Vito, Alessandro ; Puglielli, Edoardo ; Lacidogna, Giordano ; Mangiafico, Salvatore ; De Santis, Federica ; Merlino, Giovanni ; Coco, Elena ; Carità, Giuseppe ; Vallone, Stefano ; Zimatore, Domenico Sergio ; Bigliardi, Guido ; Semeraro, Vittorio ; Ferrandi, Delfina ; Mannino, Marina ; Comai, Alessio ; Besana, Michele ; Sabuzi, Federico ; Sallustio, Fabrizio ; Zini, Andrea ; Limbucci, Nicola ; Caggiula, Marcella ; Longoni, Marco ; Fainardi, Enrico ; Allegretti, Luca ; Caproni, Stefano ; Menozzi, Roberto ; Bergui, Mauro ; Critelli, Adriana ; Galluzzo, Simone ; Nicolini, Ettore ; Petralia, Benedetto ; Sponza, Massimo ; Casetta, Ilaria ; Zilahi De Gyurgyokai, Simone ; Saletti, Andrea ; Barchetti, Giovanni ; Dall’Ora, Elisa ; Pezzini, Alessandro ; Giannini, Nicola ; Marrama, Federico ; Saracco, Eleonora ; Bosco, Giovanni ; Allegritti, Massimiliano ; Loizzo, Nicola ; Perri, Marco ; Ferraù, Ludovica ; Napoletano, Rosa ; Russo, Monia ; Tassi, Rossana ; Filizzolo, Marco ; Da Ros, Valerio ; Cosottini, Mirco ; Casalena, Alfonsina

Abstract:

Introduction:

We aim to evaluate the association between door-to-needle time (DTN) and outcomes in a population of acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) + mechanical thrombectomy (MT) in the Italian Registry of Endovascular Treatment in Acute Stroke (IRETAS).

Materials and methods:

Patients with AIS secondary to middle cerebral artery or intracranial internal carotid artery occlusion with known times of symptoms onset, directly presenting to an MT-capable center, were included in the analysis. According to pre-defined DTN cut-off values (⩽30, ⩽45, and ⩽60 min), we evaluated the association between DTN and outcomes by multivariate logistic regression analyses. Effectiveness outcomes were 3-month functional independence, 3-month excellent outcome and successful reperfusion. Safety outcomes were any intracranial hemorrhage (ICH), symptomatic intracerebral hemorrhage (sICH), and 3-month mortality.

Results:

About 1602 patients were included in our analysis. After logistic regression analysis, a DTN ⩽ 60 min was significantly associated with 3-month functional independence (OR 1.36; 95% CI 1.02–1.82). DTNs ⩽ 30, ⩽45, and ⩽60 min were significantly associated with successful reperfusion (OR 2.66; 95% CI 1.6–4.43; OR 1.68; 95%CI 1.25-2.26; OR 1.57; 95% CI 1.21–2.05; respectively). A DTN ⩽ 60 min was also significantly associated with lower rate of any ICH (OR 0.61; 95% CI 0.43–0.86). DTNs ⩽ 30, ⩽45, and ⩽60 min were significantly associated with lower 3-month mortality (OR 0.24; 95% CI 0.08–0.67; OR 0.45; 95% CI 0.29–0.72; OR 0.58; 95% CI 0.39–0.84; respectively).

Conclusions:

In patients with AIS treated with IVT + MT, a shorter DTN is associated with better outcomes if IVT is initiated within 1 h of hospital admission.

100 Deals associated with Università degli Studi di Roma Tor Vergata

100 Translational Medicine associated with Università degli Studi di Roma Tor Vergata

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 18 Mar 2026

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 2

Other

Current Projects

Drug(Targets)	Indications	Global Highest Phase

HIVIS	HIV Infections More	Phase 2
Compound 16673-34-0 ( NLRP3 )	Myocardial Reperfusion Injury More	Pending
NPD-0414-2 ( AHR )	Inflammatory Bowel Diseases More	Pending
NPD-0414-24 ( AHR )	Inflammatory Bowel Diseases More	Pending

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis