Delving into the Latest Updates on Jining Huaneng Pharmaceutical Factory Co., Ltd with Synapse

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Nervous System Diseases

Cardiovascular Diseases

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主要目的：受试制剂复方奥美拉唑干混悬剂和参比制剂复方奥美拉唑干混悬剂（商品名：ZEGERID®）对比在健康人体内的相对生物利用度，考察两制剂的人体生物等效性。次要目的：观察受试制剂复方奥美拉唑干混悬剂和参比制剂复方奥美拉唑干混悬剂（商品名：ZEGERID®）在健康受试者中的安全性。

[Translation]

Primary objective: To compare the relative bioavailability of the test compound omeprazole dry suspension and the reference compound omeprazole dry suspension (trade name: ZEGERID®) in healthy subjects and investigate the bioequivalence of the two preparations. Secondary objective: To observe the safety of the test compound omeprazole dry suspension and the reference compound omeprazole dry suspension (trade name: ZEGERID®) in healthy subjects.

Start Date09 Apr 2018

Sponsor / Collaborator

Jining Huaneng Pharmaceutical Factory Co., Ltd

CTR20180353 / CompletedPhase 1

复方奥美拉唑干混悬剂在健康受试者中随机、开放、双周期、双交叉空腹状态下的生物等效性试验

[Translation] A randomized, open-label, two-period, double-crossover bioequivalence study of compound omeprazole dry suspension in healthy subjects under fasting conditions

主要目的：受试制剂复方奥美拉唑干混悬剂和参比制剂复方奥美拉唑干混悬剂（商品名：ZEGERID®）对比在健康人体内的相对生物利用度，考察两制剂的人体生物等效性。次要目的：观察受试制剂复方奥美拉唑干混悬剂和参比制剂复方奥美拉唑干混悬剂（商品名：ZEGERID®）在健康受试者中的安全性。

[Translation]

Primary objective: To compare the relative bioavailability of the test preparation compound omeprazole dry suspension and the reference preparation compound omeprazole dry suspension (trade name: ZEGERID®) in healthy subjects and investigate the bioequivalence of the two preparations. Secondary objective: To observe the safety of the test preparation compound omeprazole dry suspension and the reference preparation compound omeprazole dry suspension (trade name: ZEGERID®) in healthy subjects.

Start Date03 Apr 2018

Sponsor / Collaborator

Jining Huaneng Pharmaceutical Factory Co., Ltd

100 Clinical Results associated with Jining Huaneng Pharmaceutical Factory Co., Ltd

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0 Patents (Medical) associated with Jining Huaneng Pharmaceutical Factory Co., Ltd

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1

Literatures (Medical) associated with Jining Huaneng Pharmaceutical Factory Co., Ltd

16 Feb 2022·Journal of Chromatographic ScienceQ4 · CHEMISTRY

Study on the Pharmacokinetic Profiles of Three Ingredients in Qilong Capsules and Their Potential Interactions in Rats by LC–MS/MS

Q4 · CHEMISTRY

Article

Author: Liu, Ruichen ; Li, Zhen ; Zang, Hengchang ; Liang, Huiliang

Abstract Qilong capsule (QLC) is a well-known Traditional Chinese Medicine, and it has a long history for the treatment of ischemic stroke. Its major ingredients are saponins, such as paeoniflorin, amygdalin and calycosin-7-glucoside, contributing to vasodilation function. In this study, a simple, rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry method was developed to determine three bioactive ingredients in rat plasma after oral administration of QLC. A simple acetonitrile precipitation method was introduced during the sample preparation. Chromatographic separation was performed on a Shiseido CAPCELL PAC MGIII-C18 column using a gradient elution with acetonitrile and water (0.1% formic acid) as a mobile phase, and the chromatographic separation was 5 min. The methodological evaluation showed that this method had a high sensitivity (the lower limit of quantification was 1 ng/mL for calycosin-7-glucoside, 5 ng/mL for paeoniflorin, 5 ng/mL for amygdalin), satisfactory accuracy (relative error ≤ ±15%) and precision (relative standard deviation ≤15%). Then, the analytical method was applied to the pharmacokinetic study in rats following oral administration of the extracts in QLC. Meanwhile, the pharmacokinetic parameters of complex system in QLC were analyzed and the potential interaction between ingredients was explored. The present quantification method and pharmacokinetic study will provide a meaningful reference for the formulas research of QLC in the treatment of ischemic stroke.Highlight

100 Deals associated with Jining Huaneng Pharmaceutical Factory Co., Ltd

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100 Translational Medicine associated with Jining Huaneng Pharmaceutical Factory Co., Ltd

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Pipeline

Pipeline Snapshot as of 27 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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