Delving into the Latest Updates on University of Azad Jammu and Kashmir with Synapse

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Nervous System Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

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Disease Domain	Count

Nervous System Diseases	3

Top 5 Drug Type	Count

Small molecule drug	3

Top 5 Target	Count

MAO-A x MAO-B	2
NF-κB(Nuclear factor NF-kappa-B complex)	1

This paper investigates interaction of ns laser pulses with n-type Si under two irradiation conditions: ambient air and flowing air at 16 ms^-1.This study was conducted using laser fluence of 1.5-2 J-cm^-2, and laser shots number n (6 ≥ n ≥ 1) at focus and off-focus.Two different topog. phenomena were observed; in flowing air, at focus surface etching dominates, while ripple formation occurred in both conditions.Both of them were strongly dependent on the laser shots and irradiation condition at focus and off-focus.In air flow, at focus or off-focus, randomly distributed etched pits form, increasing in size and population with more laser pulses.Off-focus in air flow, formation of etched patches was reduced and regular ripples transitioned into broken ripples as the shot number increased.Contrary to this, in ambient air, no etching was seen, and persistent ripples were formed, showing localised topog. interruption and fractured features with increased shots.The broken features were more dominant for the increased laser shots due to the incubation impact and the hydrodynamic instabilities of molten silicon.Raman anal. revealed a striking difference in properties of textured Si under two conditions.The distinct topog. features in air flow and ambient air reflect altered melt dynamics and ripple formation driven by laser interaction.It shows a critical role of air flow in selectively altering the surface topog. through etching, ripple formation or a combination of both.

01 Feb 2025·Journal of Hazardous Materials Advances

Biodegradation of polyvinyl chloride using vermibacteria under variable physicochemical conditions

Author: Mani, Ravishankar Ram ; Andleeb, Saiqa ; Chang, Soon Woong ; Jones, Sumathi ; Ali, Muhammad Ishtiaq ; Chandrasekaran, Murugesan ; Radhakrishnan, Arunkumar ; Imdad, Kaleem ; Balachandar, Ramalingam ; Ravindran, Balasubramani ; Munir, Muqaddas

Plastic has a significant hazard to the environment, but its impact could be mitigated through degradation processes.Biodegradation of plastic wastes by using microorganisms is an environment-friendly method.In the current study, vermibacterial strains i.e.Bacillus mycoides, Bacillus megaterium, Bacillus mojavensis, Bacillus thuringiensis, and Bacillus paranthracis, were selected to evaluate the degrading impact on polyvinyl chloride (PVC) and tested under various physicochem. conditions such as pH (7, 5, 9), temperature (37 °C and 50 °C), carbon sources (Glucose and sucrose), and nitrogen sources (yeast extract and peptone).Liquid culture technique was used to investigate the chloride production and solid media experiment was employed for biodegradation of polyvinylchloride films.Bacillus mojavensis and Bacillus paranthracis showed maximum chloride production of 88.4 % and 87.8 % at pH 7 and 50 °C in the absence of carbon and nitrogen sources.On the other hand, Bacillus megaterium and Bacillus mojavensis showed maximum chloride production (91 % and 91.7 %) at pH 7 and 50 °C in the presence of glucose and yeast extract after 5 days of incubation while all vermibacteria indicated the highest chloride production at pH 9 and 50 °C in the presence of sucrose and yeast extract except Bacillus thuringiensis.Similarly, Bacillus mojavensis, Bacillus paranthracis, and Bacillus thuringiensis showed maximum chloride production in the presence of sucrose and peptone.SEM was used to check the morphol. changes of the PVC film after vermibacteria treatments and results revealed that vermibacteria attached to PVC films and validated the changes in surface topog.Fourier-transform IR spectroscopy also revealed the changes in functional group intensity on both vermibacteria-treated PVC films compared to the control.It was concluded that plastic biodegradation via vermibacteria could be a potential source not only to eliminate plastic-based environmental issues but also holds the potential to significantly improve human health, reduce pollution, and support sustainable practices for a cleaner and healthier environment.

30 Jan 2025·Modern Physics Letters B

Joule heating effects on triple diffusive free convective MHD flow over a convective surface: A Lie-group transformation analysis

Author: Siddiqui, Md Irfanul Haque ; Ali, Bilal ; Khan, Umar ; Islam, Ammara ; Mahmood, Zafar

This work integrates the Boussinesq approximation and magnetohydrodynamic effects to investigate the dynamics of incompressible triple diffusive fluid flow along a linearly stretched surface. Novel insights are revealed by contrasting instances with opposing and helpful flows. The partial differential equations are symmetrically reduced using Lie-group transformations, which make the Runge–Kutta shooting technique easier to solve. The effects of concentration buoyancy ratio, magnetic parameter, concentration parameter, and Lewis number on temperature, velocity, and concentration profiles are explained through graphical displays. Our results show that in both flow situations, the velocity distribution is decelerated by the magnetic parameter, and the salt concentration distributions are similarly affected by buoyancy ratio factors. Additionally, a higher Lewis number is associated with lower mass and heat transfer rates in the opposing and assisting fluid.

100 Deals associated with University of Azad Jammu and Kashmir

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100 Translational Medicine associated with University of Azad Jammu and Kashmir

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Pipeline

Pipeline Snapshot as of 02 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Compounds 5f(UAJ&K) ( MAO-A x MAO-B )	Alzheimer Disease More	Preclinical
Jietacin Derivative(Kitasato University) ( NF-κB )	Alzheimer Disease More	Preclinical
Compounds 5a(UAJ&K) ( MAO-A x MAO-B )	Alzheimer Disease More	Preclinical