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Overview

Tags

Urogenital Diseases

Neoplasms

Endocrinology and Metabolic Disease

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

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Disease Domain	Count

Neoplasms	4
Endocrinology and Metabolic Disease	4

Top 5 Drug Type	Count

Small molecule drug	4

Top 5 Target	Count

PARP1 x PARP2	4

BACKGROUNDPolyethylene terephthalate (PET), a commonly used polymer in various food and plastic bag containers, has raised significant concerns regarding its environmental and human health risks. Despite its prevalent use, the impact of PET exposure on aquatic environments and its potential to induce neurotoxic conditions in species remain poorly understood. Furthermore, the mechanisms underlying amelioration through natural product intervention are not well-explored. In light of these gaps, our study aimed to elucidate the neurotoxic effects of PET in zebrafish through waterborne exposure, and to mitigate its neurological impact using luteolin-graphene oxide nanoparticles.METHODS AND RESULTSOur investigation revealed that exposure to PET in water triggered adverse effects in zebrafish larvae, particularly in the head region. We observed heightened oxidative stress, lipid peroxidation, and cell death, accompanied by impaired antioxidant defense enzymes. Furthermore, abnormal levels of acetylcholine esterase and nitric oxide in the zebrafish brain indicated cognitive impairment. To address these issues, we explored the potential neuroprotective effects of luteolin-graphene oxide nanoparticles. These nanoparticles demonstrated efficacy in localizing within the zebrafish brain, enhancing their therapeutic impact against PET exposure. Treatment with luteolin-graphene oxide nanoparticles not only mitigated PET-induced neurological alterations but also exhibited a neuroprotective effect. This was evidenced by the regulation of pro-inflammatory cytokine gene expression in the zebrafish brain. Additionally, normalization of locomotory behavior in PET-exposed zebrafish following nanoparticle treatment underscored the potential effectiveness of luteolin-graphene oxide nanoparticles as a treatment against PET-induced neurotoxicity.CONCLUSIONSIn summary, our study emphasizes the urgent need to investigate the environmental and health risks associated with PET. We demonstrate the potential of luteolin-graphene oxide nanoparticles as an effective intervention against PET-induced neurotoxicity in zebrafish.

01 Dec 2024·Journal of Molecular Structure

Anti-fouling poly(lactic)acid membrane incorporating titanium dioxide‐coated biochar composites for the separation of lipopeptides from Bacillus subtilis fermentation broth

Author: Kumar, Vaidyanathan Vinoth ; Patil, Atharva ; Sethi, Purvi ; Devi, Eggoni Gayathri ; Venkataraman, Swethaa ; Rajendran, Devi Sri

This study focuses on developing anti-fouling membranes composed of poly(lactic)acid (PLA) incorporating titanium dioxide-coated biochar composites, aiming to sep. the lipopeptides from clarified Bacillus subtilis fermentation broth efficiently.The surface area of the Ti-biochar composites, incorporated into the PLA membrane, was measured as 191.69 m2/g and the water contact angle of the optimal PLA/Ti-biochar membrane was determined to be 62.3°, indicating its hydrophilic nature.The PLA membrane's pure water flux, containing 1 wt % Ti-biochar was 174.61±0.5 L m-2h-1 with the water content of 86.73±0.8%, and porosity of 44.72±0.3%.Then, Bacillus subtilis lipopeptides were separated by the optimal PLA/Ti-biochar membrane, and their characteristics were compared to the crude sample.Addnl., the purified lipopeptides demonstrated enhanced antimicrobial properties, with a significantly lower min. inhibitory concentration (MIC) of 1.7±0.52μg/mL against Staphylococcus aureus and 1.5±0.24μg/mL against Fusarium oxysporum, compared to the crude lipopeptides, which had MIC values of 5.5±0.26μg/mL and 4.2 ±0.45μg/mL, resp.The purified lipopeptides were confirmed by high-performance liquid chromatog. and mass spectrometry.These results underscore the antifouling characteristics of the fabricated PLA/Ti-biochar membrane, positioning it as a promising candidate for the separation of biol. mols.

01 Nov 2024·Waste and Biomass Valorization

A Comprehensive Review on the Refinery of Citrus Peel Towards the Production of Bioenergy, Biochemical and Biobased Value-Added Products: Present Insights and Futuristic Challenges

Author: Vaidyanathan, Vinoth Kumar ; Rangasamy, Gayathri ; Venkataraman, Swethaa ; Kumar, P. Senthil ; Rajendran, Devi Sri

Abstract: The widespread nature of citrus cultivation, processing, and consumption on a global scale results in a substantial volume of byproducts within the citrus processing industries.The indiscriminate disposal of these byproducts, without a proper treatment and disposal methods, poses a significant environmental hazard.Amongst, citrus peel waste being a prolific byproduct, is generated on a large scale and is increasingly gaining recognition for its industrial potential in producing fuels and chems.This encompasses biofuels such as ethanol and biogas, bioactive compounds like flavonoids, alkaloids, essential oils, D-limonene, and pectin, as well as various biochem. compounds including organic acid, biosurfactants, enzymes, and bioplastics through strategic valorization processes.The valorization process entails a variety of techniques, including chem., biol., and phys. treatment methods.Phys. treatments, such as microwave and ultrasound-assisted extraction methods, are employed, alongside extraction using solvents and biol. methods including fermentation and saccharification, which are integral components of the valorization process.Each of these methodologies contributes to the production of the aforementioned value-added compoundsFurthermore, the recently developed supercritical fluid can also be employed for extracting these valuable compounds, enhancing the versatility and efficiency of the valorization process.This review addresses a refinery strategy, emphasizing the incorporation of a suitable valorization/treatment approach to transform citrus peel waste into high-value-added products.

100 Deals associated with SRM Institute of Science and Technology

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100 Translational Medicine associated with SRM Institute of Science and Technology

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Pipeline

Pipeline Snapshot as of 23 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

4

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

(+)-Zampanolide ( PARP1 x PARP2 )	Ovarian Serous Tumor More	Preclinical
Alisiaquinone C ( PARP1 x PARP2 )	Ovarian Serous Tumor More	Preclinical
Alisiaquinone A ( PARP1 x PARP2 )	Ovarian Serous Tumor More	Preclinical
Ascomindone D ( PARP1 x PARP2 )	Ovarian Serous Tumor More	Preclinical