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Disease Domain	Count

Endocrinology and Metabolic Disease	1
Hemic and Lymphatic Diseases	1
Immune System Diseases	1
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DNA	1

AbstractThe effects of partial blood exchange with Fluosol-DA on hepatic microsomal oxidative metabolism have been studied in the rat. Antipyrine clearance (Cl) was used as an in-vivo measure of the activity of the mixed function oxidase system. Rats were partially exchanged with Fluosol-DA and dosed with antipyrine at selected time intervals following exchange. No change in antipyrine Cl was observed at 0.5 h, but there was a statistically significant decrease at 24 h and then an increase by more than 50% relative to control at 48 and 72 h. These data indicate that the effects of Fluosol-DA on hepatic function are time-dependent and that Fluosol-DA has the potential both to inhibit and to enhance hepatic metabolism. The possibility of altered hepatic metabolism should be considered when patients transfused with Fluosol-DA are given drugs primarily metabolized by the mixed function oxidase system.

12 Apr 2011·Journal of Pharmacy and Pharmacology

Excipient compatibility as assessed by isothermal microcalorimetry

Author: Phipps, Mark A ; Long, Stacey T ; Viscomi, Frank ; Winnike, Richard A

01 Jan 2005·Antimicrobial Agents and ChemotherapyQ2 · MEDICINE

Single-Dose Safety and Pharmacokinetics of Amprenavir (141W94), a Human Immunodeficiency Virus Type 1 (HIV-1) Protease Inhibitor, in HIV-Infected Children

Q2 · MEDICINE

Article

Author: Lou, Yu ; Kovacs, Andrea ; Homans, James D. ; Chadwick, Ellen G. ; Symonds, William T. ; Yogev, Ram

ABSTRACT A phase I, open-label, dose-escalating trial was conducted to evaluate the safety, tolerability, and pharmacokinetics of single, oral doses of amprenavir (141W94), a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) protease, in 20 HIV-infected children 4 to 12 years of age. The doses of amprenavir evaluated, 5, 10, 15, and 20 mg/kg of body weight, were comparable to those evaluated in adult phase I and II studies. The most common clinical adverse event associated with amprenavir, administered as soft gelatin capsules, was nausea. Amprenavir was rapidly absorbed, with a mean time to maximum concentration ( Tmax ) occurring 0.95 to 1.58 h after dosing. The area under the concentration-time curve (AUC 0→∞ ) was dose proportional, and the mean maximum plasma concentration ( Cmax ) increased linearly in a less than dose-proportional manner. Amprenavir was eliminated relatively slowly, with a mean terminal-phase half-life ( t1/2 ) of 6.17 to 8.28 h. The t1/2 , apparent total clearance, and apparent volume of distribution during the elimination phase were dose independent. Considerable interpatient variability was seen for all pharmacokinetic parameters of amprenavir. The results of this study suggest that 20 mg of amprenavir/kg administered twice a day should be used in future pediatric studies.

1

News (Medical) associated with Glaxo Wellcome, Inc.

05 Sep 2024

·www.globenewswire.com

Stockholders Vote to Elect Madhavan Balachandran to Board of Directors

WOBURN, Mass., Sept. 05, 2024 (GLOBE NEWSWIRE) -- Replimune Group, Inc. (Nasdaq: REPL), a clinical stage biotechnology company pioneering the development of a novel class of oncolytic immunotherapies, today announced that Madhavan (Madhu) Balachandran was elected to Replimune’s Board of Directors at the Company’s annual meeting of stockholders. “We are thrilled to welcome Madhu to Replimune’s Board of Directors,” said Sushil Patel, Ph.D., Chief Executive Officer of Replimune. “Madhu is an accomplished life sciences industry executive with decades of valuable experience in commercial development, manufacturing and operations. We look forward to working with Madhu as we continue to prepare for commercialization and believe his addition will further strengthen our Board.” Mr. Balachandran is a biopharma industry executive and has more than 40 years of experience in manufacturing and operations. He was previously with Amgen Inc., where he served as Executive Vice President of Operations, overseeing global operations and reporting directly to the CEO. Mr. Balachandran held senior operations positions at Burroughs Wellcome Co. Mr. Balachandran holds an MBA from East Carolina University, a MS in Chemical Engineering from the State University of New York at Buffalo, and a bachelor’s degree in chemical engineering from The Indian Institute of Technology, Mumbai. About Replimune Replimune Group, Inc., headquartered in Woburn, MA, was founded in 2015 with the mission to transform cancer treatment by pioneering the development of a novel portfolio of oncolytic immunotherapies. Replimune’s proprietary RPx platform is based on a potent HSV-1 backbone intended to maximize immunogenic cell death and the induction of a systemic anti-tumor immune response. The RPx platform is designed to have a unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response. The RPx product candidates are expected to be synergistic with most established and experimental cancer treatment modalities, leading to the versatility to be developed alone or combined with a variety of other treatment options. For more information, please visit www.replimune.com. Investor InquiriesChris BrinzeyICR Westwicke339.970.2843chris.brinzey@westwicke.com Media InquiriesArleen GoldenbergReplimune917.548.1582media@replimune.com

Executive ChangeImmunotherapy

100 Deals associated with Glaxo Wellcome, Inc.

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100 Translational Medicine associated with Glaxo Wellcome, Inc.

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Pipeline

Pipeline Snapshot as of 05 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Approved

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Melphalan ( DNA )	Breast Cancer More	Approved
Colfosceril Palmitate	Respiratory Distress Syndrome in Premature Infants More	Withdrawn
Raluridine ( RT )	HIV Infections More	Discontinued
Netivudine	HIV Infections More	Discontinued
Ranitidine Hydrochloride ( H2 receptor )	HIV Infections More	Discontinued