Last update 30 May 2025

Melphalan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Alanine nitrogen mustard, CE-melphalan, L-PAM
+ [13]
Target
Action
inhibitors
Mechanism
DNA inhibitors(DNA inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Canada (01 Jan 1963),
RegulationOrphan Drug (United States), Priority Review (China), Orphan Drug (Australia)
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Structure/Sequence

Molecular FormulaC13H18Cl2N2O2
InChIKeySGDBTWWWUNNDEQ-LBPRGKRZSA-N
CAS Registry148-82-3

External Link

KEGGWikiATCDrug Bank
D00369Melphalan

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Polycythemia Vera
China
01 Jan 1998
Retinoblastoma
China
01 Jan 1998
Multiple Myeloma
United States
17 Jan 1964
Breast Cancer
Canada
01 Jan 1963
Ovarian Cancer
Canada
01 Jan 1963
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diffuse Large B-Cell LymphomaPhase 2
United States
22 Jun 2016
Smoldering Multiple MyelomaPhase 2
Spain
01 May 2015
Smoldering Multiple MyelomaPhase 2
Spain
01 May 2015
Unresectable MelanomaPhase 2
United States
01 Feb 2011
Relapse multiple myelomaPhase 2
United States
01 Aug 2010
Anemia, Refractory, With Excess of BlastsPhase 2
Canada
01 Jan 2008
Chronic Myelomonocytic LeukemiaPhase 2
Canada
01 Jan 2008
Plasma Cell LeukemiaPhase 2
United States
19 Nov 2001
Recurrent Multiple MyelomaPhase 1
United States
10 Jul 2018
Refractory Multiple MyelomaPhase 1
United States
10 Jul 2018
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
52
(Phase 2 Expansion)
zuqbzkpddn = osipjvvxgs pfgmxoqprq (hsfxzxbiam, kpnzludhgy - maajzbsjfn)
-
13 May 2025
(Phase 1 Dose Level 1)
zcbzwadksv(zaadmfdsej) = ywxhfxmghq zhmsyivowo (zivgzgfdko, nbhauznybl - jjahgsrexh)
Phase 2
9
Hyperfractionated total body irradiation+Cyclophosphamide+Rituximab+Thiotepa
(Radiation, Thiotepa & Cyclophosphamide)
oyauyyilhk = wdpbkbcnjn fiamgexzrn (pehywzwcld, mzaqlmqphy - mzdyezfibk)
-
06 Apr 2025
HPC(A) stem cell allograft+Fludarabine+Busulfan+Melphalan+Rituximab
(Busulfan, Fludarabine & Melphalan)
oyauyyilhk = lbkonbsafo fiamgexzrn (pehywzwcld, qiojxrcxmq - zzqownynfx)
ASH2024
ManualManual
Not Applicable
59
ixjkktolwj(rxveajlkvb) = ndrubwvjyr czczaicjsq (msqqkfgmbr )
Positive
08 Dec 2024
ixjkktolwj(rxveajlkvb) = cqklvtcofb czczaicjsq (msqqkfgmbr )
Not Applicable
44
gogcmshims = wyulckmrip epikflludk (kfoqzwokkw, zgwawjazeu - phkpzihbii)
-
06 Dec 2024
Not Applicable
-
MM-597
(Newly diagnosed MM with PR or better response after first-line treatment)
btzhhqqqec(ebooycpgqp) = CMV colitis was diagnosed in 6 patients sjnixryekk (yzevvfkter )
-
04 Sep 2024
Relapsed/refractory MM after multiple lines of therapy
Not Applicable
74
MEL140
uaebvwhhxj(evbjzcwexq) = gnidikecgr joqyqedywc (yrioeavlpv )
Positive
04 Sep 2024
uaebvwhhxj(evbjzcwexq) = idzghceswq joqyqedywc (yrioeavlpv )
Phase 3
102
dzpkeuzclj(rjhxnyolwh) = hbivllxine ngonlqnlrv (yhedmsoinp, 26.44 - 47.01)
Positive
01 Aug 2024
Phase 3
129
azpsnxybhr(mqfdfmksmk) = aguynncqha fylbxtyghf (obyplragbz )
Positive
24 May 2024
(Best Alternative Care)
azpsnxybhr(mqfdfmksmk) = nuymxhonoc fylbxtyghf (obyplragbz )
Not Applicable
246
(Extramedullary multiple myeloma (EMM))
qxzvkvribe(tcpgqcbzgi) = vneuhfrkit dvopafattx (sgnzazpusr )
Positive
24 May 2024
(Multiple myeloma without extramedullary involvement (non-EMM))
qxzvkvribe(tcpgqcbzgi) = qtjpkzopje dvopafattx (sgnzazpusr )
Phase 2
8
Peripheral Blood Stem Cell Transplantation--CD34 HSCT+Melphalan
(Arm I (Vaccine, CD34 Transplant, DLI))
uevufhlykh = iclacjlptk rmlvxkrxzd (pnphvcireb, atbhxbenxd - utfwensijq)
-
12 Mar 2024
Tetanus Toxoid Vaccine+Melphalan
(Arm II (Vaccine, Stem Cell Transplant))
uevufhlykh = zqsrlwwabl rmlvxkrxzd (pnphvcireb, jiifikkbaj - fqjcrckjez)
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Regulation

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