Delving into the Latest Updates on Hangzhou MSD Pharmaceutical Co. Ltd. with Synapse

Overview

Tags

Nervous System Diseases

Congenital Disorders

Endocrinology and Metabolic Disease

Diagnostic radiopharmaceuticals

Small molecule drug

Chemical drugs

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Endocrinology and Metabolic Disease	1
Hemic and Lymphatic Diseases	1
Infectious Diseases	1
Nervous System Diseases	1
Neoplasms	1

Top 5 Drug Type	Count

Diagnostic radiopharmaceuticals	1
Small molecule drug	1
Conjugated vaccine	1
Prophylactic vaccine	1
Chemical drugs	1

Top 5 Target	Count

PDE10A(Phosphodiesterase 10A)	1
HMG-CoA reductase	1
ELA2(Leukocyte elastase)	1

A finite element equation has been developed to simulate the squeeze casting process of a magnesium alloy wheel, a parametric model has been established to confirm the temperature field during filling and solidification process. The model can be used to investigate the effects of die design and process parameters (die temperature, pressure etc.) on the quality of castings.

Guangdong Huagong

Synthesis of Tetrahydroquinolines via Intramolecular Cyclopropanation

Author: Zheng Jianping ; Tang Yanhua

A new method for synthesis of cyclopropane-fused tetrahydroquinolines via rhodium-catalyzed intramol. cyclopropanation is reported.With 5 mol % of Rh2(piv)4 as catalyst, 1, 2-dichloroethane as solvent, ortho-vinylaniline substituted 1-sulfonyl-1, 2, 3-triazoles could be converted to useful target mols. at 50 °C with satisfactory yields.

Advanced Materials Research

The Numerical Simulation and Optimization of Squeeze Casting Process for Producing Magnesium Wheels

Author: Tang, Hong Qiang ; Yao, Rong Qing

The simulation of squeeze casting process of a magnesium alloy wheel was practice. Using professional casting software, the temperature field during filling and solidification process, and then the potential defects were forecasted and previewed. It was found that there would be shrinkage defects at the center and the junctions between the rim and the spokes of the wheel. It is better to choose a mould temperature for a better cast property at meet of full-filling. Number of programs are analyzed and compared through orthogonal experiment. And the best parameter team is educed through analysis. It is confirmed that the potential micro-shrinkage is reduced by simulated again using the best parameter team. And the cast property is enhanced.

100 Deals associated with Hangzhou MSD Pharmaceutical Co. Ltd.

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100 Translational Medicine associated with Hangzhou MSD Pharmaceutical Co. Ltd.

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Pipeline

Pipeline Snapshot as of 23 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

3

1

Approved

Other

2

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Simvastatin ( HMG-CoA reductase )	Hyperlipoproteinemia Type V More	Approved
[11C]MK-8193 ( PDE10A )	Neoplasms More	Preclinical
24 valent pneumococcal polysaccharide conjugate vaccine(MSD)	Streptococcal Infections More	Preclinical
MK-0339 ( ELA2 )	Neutropenia More	Preclinical
PFE-360 ( LRRK2 )	Parkinson Disease More	Pending