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Last update 08 May 2025

JSS College of Pharmacy

Education|India

Last update 08 May 2025

Overview

Pipeline

Deal

Translational Medicine

Overview

Clinical Trials associated with JSS College of Pharmacy

CTRI/2023/06/053938

/ CompletedPhase 2/3IIT

Comparative evaluation of Presurgical Nasoalveolar Molding using digitally designed & 3D printed NAM appliance with modified Graysons NAM appliance in unilateral cleft lip and palate infants- A Randomized Controlled Trial - NIL

Start Date25 Jun 2023

Sponsor / Collaborator

JSS College of Pharmacy

100 Clinical Results associated with JSS College of Pharmacy

0 Patents (Medical) associated with JSS College of Pharmacy

741

Literatures (Medical) associated with JSS College of Pharmacy

01 Jun 2025·Morphologie

Analysis of heat induced changes in dental tissue for forensic application: A scanning electron microscope study

Article

Author: Shivananda, S ; Doddawad, V G ; Mathew, R A ; Dhakshaini, M R ; Suresh, J ; Alex, A

INTRODUCTIONIn the forensic field, having accurate understanding of the macroscopic and microscopic alterations that occur in teeth when exposed to temperatures has remarkable significance. The preservation of delicate incinerated teeth is crucial in fire investigations that pertain to the temperature exposed, as well as the identification of victims. This preservation is necessary in order to conduct macroscopic and microscopic ultra-structural examinations, which provide valuable insights into the structural alterations that dental tissues undergo when exposed to low to high temperatures.AIMTo analyze the macroscopic changes and the microscopic ultra-structural changes of dental hard tissue in permanent and deciduous dentition using stereomicroscope and scanning electron microscope (SEM).MATERIALS AND METHODSThe study was conducted on 40 healthy freshly extracted teeth (20 permanent and 20 deciduous) which were subjected to predetermined temperatures i.e., 200̊C, 400̊C, 600̊C and 800̊C respectively for fifteen minutes using muffle furnace. Teeth were examined under stereomicroscope, later which they were processed for SEM examination at a magnification of 1000×. The parameter for macroscopic observation is colour, translucency and surface texture of enamel and cementum. The parameters used in microscopic observation of enamel such as pit and fissure morphology, prism pattern, crack/fracture lines, microporosity, debris, erosion, while for cementum, the parameters considered were crack presence, fissure morphology, collagen bundle arrangement, pattern, and debris. Both macroscopic and microscopic observations of dentition at different specific temperatures were calculated using percentage. The difference in macroscopic and microscopic changes between permanent and deciduous teeth were analyzed using chi-square test.RESULTSThere was no significant correlation in macroscopic and microscopic changes between permanent and deciduous teeth. Observations of dentition at various specific temperatures, both at the macroscopic and microscopic levels, revealed a noticeable reduction in the presence of each of the selected parameters in enamel and cementum.CONCLUSIONThe study revealed significant macroscopic morphological alterations and consistent microscopic ultra-structural patterns alterations that were readily observable at specified temperatures. The use of scanning electron microscopy (SEM) in the examination of burnt dental remains has a special potential for enhancing victim identification and advancing the field of forensic odontology.

01 Jun 2025·Computational Biology and Chemistry

Computational phytochemical screening for Parkinson's disease therapeutics: c-Abl and beyond

Article

Author: Yasmine, Jesmina ; Sola, Piyong ; Rymbai, Emdormi ; Buragohain, Sankarkishor ; Dutta, Bhaskar Jyoti

Parkinson's disease (PD), a rapidly growing neurodegenerative disorder, is characterized by intracellular α-synuclein aggregates. The tyrosine kinase c-Abl plays a critical role in PD pathogenesis. This study aimed to identify novel c-Abl inhibitors from natural products using molecular docking and dynamics simulations. We explored phytochemicals from Indian Medicinal Plants, Phytochemistry and Therapeutics (IMPPAT) database and employed molecular docking and molecular dynamics to discover c-Abl inhibitors. Three potential hits: IMPHY008934, IMPHY009589, and IMPHY006310 were identified. These compounds demonstrated comparable binding affinity to Nilotinib, a comparison drug. Toxicity predictions revealed IMPHY008934 and IMPHY009589 exhibited lower toxicity than Nilotinib. Molecular dynamics simulations confirmed the stability of IMPHY009589 and IMPHY008934 with c-Abl. Density functional theory (DFT) analysis showed that IMPHY006310 and IMPHY008934 displayed enhanced reactivity and polarizability. Our findings suggest these natural compounds may target c-Abl in PD pathogenesis and possibly downregulate the overexpressed α-synuclein and may serve as promising leads for PD therapy.

04 Apr 2025·Current HIV Research

Molecular Docking Studies of Scutellaria Baicalensis Targeting HIV Co-Receptor CXCR4

Article

Author: H, Rajamohamed ; N, Helina ; S, Mohamed Akram Ali ; A, Shobana ; K MF, Thawfeeq Ahmad ; S, Vinoth Kumar

Aims:The Human Immunodeficiency Virus (HIV) is a significant global health con-cern that affects millions of people worldwide. This virus targets the immune system, specifically CD4 cells, weakening the body’s ability to combat infections and diseases.Background:Scutellaria baicalensis, a plant of the genus Lamiaceae, and its root is the main part used in medicine. Pharmacological studies have shown that Scutellaria baicalensis has various activities such as anti-inflammatory, anti-viral, anti-bacterial, anti-tumor, antioxidant effects, etc.Objective:To investigate the anti-HIV activity of Scutellaria baicalensis against the HIV core-ceptor CXCR4.Methods:We conducted in-silico studies using bioinformatics tools like SWISS ADME, ProTox-II, PyRx, and Biovia Discovery Studio. Ligand structures were retrieved from the PubChem da-tabase, and the crystal structure of the target protein CXCR4 Chemokine receptor (PDB ID: 3ODU) with a resolution of 2.50 Ao was retrieved from the Protein data bank.Results:From the results, we filtered out 19 compounds with the highest binding affinity com-pared to the native ligand (-7.9 kcal/mol), which ranges from -10.1 kcal/mol to -8.0 kcal/mol. For the 19 compounds, we conducted ADME and Toxicity studies. From the studies, Baicalin, Wog-onoside, and Oroxylin A-7-O-Glucuronide possess binding affinity of -10.1 kcal/mol, -9.6 kcal/mol, and -9.2 kcal/mol, which is greater than the native ligand (-7.9 kcal/mol).Conclusion:Thus, Baicalin may possess the most potential activity against HIV. Moreover, fur-ther in-vitro and in-vivo studies are needed to evaluate their biological potential, and this work may help scientists in their future studies.

100 Deals associated with JSS College of Pharmacy

100 Translational Medicine associated with JSS College of Pharmacy

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