Delving into the Latest Updates on CytoCares Shanghai, Inc. with Synapse

Overview

Tags

Neoplasms

Immune System Diseases

Hemic and Lymphatic Diseases

Trispecific T-cell engager (TriTE)

Trispecific antibody

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	2
Hemic and Lymphatic Diseases	1
Immune System Diseases	1

Top 5 Drug Type	Count

Trispecific antibody	1
Trispecific T-cell engager (TriTE)	1

Top 5 Target	Count

CD19 x CD28 x CD3	1
CD molecules	1

（1）评估CC312在复发/难治性CD19阳性的B细胞性非霍奇金淋巴瘤和B淋巴细胞白血病患者中的安全性和耐受性；（2）探索CC312的剂量限制性毒性（DLT），并确定CC312在复发/难治CD19阳性的B细胞性非霍奇金淋巴瘤患者中的最大耐受剂量（MTD）和/或II期推荐剂量（RP2D）。

[Translation]

(1) Evaluate the safety and tolerability of CC312 in patients with relapsed/refractory CD19-positive B-cell non-Hodgkin's lymphoma and B-cell leukemia; (2) Explore the dose-limiting toxicity (DLT) of CC312 and determine the maximum tolerated dose (MTD) and/or phase II recommended dose (RP2D) of CC312 in patients with relapsed/refractory CD19-positive B-cell non-Hodgkin's lymphoma.

Start Date25 Jul 2023

Sponsor / Collaborator

CytoCares Shanghai, Inc.Startup

100 Clinical Results associated with CytoCares Shanghai, Inc.

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0 Patents (Medical) associated with CytoCares Shanghai, Inc.

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1

Literatures (Medical) associated with CytoCares Shanghai, Inc.

01 Feb 2024·Immunotherapy

A Trispecific Antibody Induces Potent Tumor-Directed T-Cell Activation and Antitumor Activity by CD3/CD28 Co-Engagement

Article

Author: Chen, Li ; Zhu, Huaxing ; Ren, Pu ; Tong, Li ; Xu, Qiming ; Xian, Weiwei ; Yang, Yingying ; Li, Debin ; Qian, Wenjing ; Yu, Weiwei ; Pan, Fangfang ; Zhu, Xufeng ; Dai, Ruixue ; Ding, Jianfeng

Aim: A novel CD19xCD3xCD28 trispecific antibody with a tandem single-chain variable fragments (scFv) structure was developed for the treatment of B-cell malignancies. Methods: The trispecific antibody in inducing tumor-directed T-cell activation and cytotoxicity was evaluated in vitro and in vivo and compared with its bispecific counterpart BiTE-CD19xCD3 lacking a CD28-targeting domain. Results: The trispecific antibody with a co-stimulatory domain exhibited augmented T-cell activation and memory T-cell differentiation capability and it induced faster tumor cell lysis than the bispecific antibody. RNAseq analysis revealed that the trispecific antibody modulates CD3/TCR complex-derived signal and upregulates antiapoptotic factors to influence the survival of T cells. Conclusion: By CD3/CD28 co-engagement, the trispecific antibody demonstrated its advantages in T-cell immunity and potential use as a more powerful and long-lasting T-cell engager.

100 Deals associated with CytoCares Shanghai, Inc.

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100 Translational Medicine associated with CytoCares Shanghai, Inc.

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Pipeline

Pipeline Snapshot as of 24 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

Phase 1 Clinical

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