Heilongjiang Chamgree Pharmaceutical Co, Ltd.

Primary objective: Using the ibuprofen suspension produced by Heilongjiang Zhonggui Pharmaceutical Co., Ltd. as the test preparation and the ibuprofen suspension (trade name: Meilin®) produced by Shanghai Johnson Pharmaceutical Co., Ltd. as the reference preparation, the pharmacokinetic parameters and relative bioavailability of the two preparations after a single administration in the fasting and postprandial state were investigated to evaluate whether the two preparations are bioequivalent. Secondary objective: To evaluate the safety of the ibuprofen suspension test preparation and the reference preparation after a single oral administration in fasting/postprandial state in healthy Chinese subjects.

The ibuprofen suspension produced by Heilongjiang Zhonggui Pharmaceutical Co., Ltd. was used as the test preparation, and the ibuprofen suspension (trade name: Meilin®) produced by Shanghai Johnson Pharmaceutical Co., Ltd. was used as the reference preparation. The pharmacokinetic parameters of ibuprofen suspension under fasting and postprandial conditions were investigated, the rationality of the blood drug concentration analysis method, blood sampling time, sampling volume, etc. were verified, and the bioequivalence and intra-individual coefficient of variation of the two preparations were preliminarily evaluated. Secondary objective: To evaluate the safety of the test preparation and reference preparation of ibuprofen suspension after a single fasting/postprandial oral administration in healthy Chinese subjects.