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Overview

Although L-homoserine is a naturally occurring amino acid with important biological properties, only few examples of homoseryl peptides are known, which have been mainly prepared by using either the benzyl [1,2] or the trityl [3,4] group for the O-protection. Furthermore, homoserine amides are potential precursors for the introduction of a ring, which can act as conformational constraints in peptides and peptidomimetics [5-7]. Herein, we report new methods for the preparation of homoserine amides and their conversion into

01 Jul 2000·Journal of AOAC INTERNATIONALQ4 · AGRICULTURAL & FORESTRY SCIENCE

Liquid Chromatographic Determination of Lysine, Methionine, and Threonine in Pure Amino Acids (Feed Grade) and Premixes: Collaborative Study

Q4 · AGRICULTURAL & FORESTRY SCIENCE

Article

Author: Kang, K.-R. ; Llames, C. R. ; Empie, M. W. ; Fontaine, Johannes ; Eudaimon, Marcelle ; Schwadorf, K. ; Verbeek, K. ; Pierre, F. ; Lee, H. ; Hoeg, T. ; Legler, J. ; Bargholz, J. ; Eriksson, S. ; Katayama, M. ; Van der Lee, R. A. ; MacDonald, J. L. ; Regnier, J-M.

AbstractA total of 17 laboratories (including one author's laboratory) participated in a collaborative study for determination of lysine, methionine, and threonine in trade products or concentrated amino acid premixes. Thirteen samples, 4 pure amino acids and 6 premixes, including 3 Youden matched pairs, were analyzed. The applied liquid chromatographic (LC) method using cation-exchange resin and post-column derivatization with ninhydrin or o-phthaldialdehyde was shown to be accurate and specific for the analytes. Titration procedures, normally used for the assay of pure amino acids, are unspecific and the accuracy of the results can be affected by impurities. Repeatability relative standard deviations, RSDr, ranged from 0.84 to 1.17% for pure amino acids and from 0.50 to 1.68% for premixes; reproducibility relative standard deviations RSDR, ranged from 1.52 to 2.31% for pure amino acids and from 1.48 to 2.59% for premixes. Recoveries were between 97.5 and 102.8% of the expected amino acid assays. The method has been adopted Official First Action status by AOAC INTERNATIONAL.

01 Jan 2000·Materialgruppenmanagement

Materialgruppenmanagement bei Unternehmensfusionen

Author: Uwe Wagenknecht ; Stephan Zub

100 Deals associated with Degussa AG

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100 Translational Medicine associated with Degussa AG

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Pipeline

Pipeline Snapshot as of 26 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

AWD-5239 ( 5-HT2 receptor )	Cognition Disorders More	Discontinued
Anaxirone ( DNA )	Neoplasms More	Discontinued
Teroxirone ( DNA )	Neoplasms More	Discontinued