Randomized Controlled Trial of COVID-19 booster vaccine for intramuscular versus subcutaneous administration assessing immunogenicity and reactogenicity. in pharmacies/vaccination sites in Aotearoa, New Zealand.

Start Date30 Mar 2024

Sponsor / Collaborator

Medical Research Institute of New Zealand

ACTRN12623000958684 / RecruitingPhase 2

The Prophylaxis against Early Ventilator Associated Lower Respiratory Tract Infection (PREVENT LRTI) trial. A phase 2 multi-centre, randomized, double-blind, placebo-controlled parallel group clinical trial.

Start Date09 Feb 2024

Sponsor / Collaborator

Medical Research Institute of New Zealand

100 Clinical Results associated with Medical Research Institute of New Zealand

0 Patents (Medical) associated with Medical Research Institute of New Zealand

540

Literatures (Medical) associated with Medical Research Institute of New Zealand

27 Aug 2024·JAMA

Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis

Article

Author: Psirides, Alex ; Waddell, Gail ; McGuinness, Shay ; Wrey Brown, Caroline ; Salberg, Armorel ; Morley, Olivia ; Butler, Jenie ; Walden, Andrew ; Sinclair, Simon ; Hester, Natalie ; Headlam, Evie ; Race, Pam ; Roberts, Jason A. ; Rechnitzer, Thomas ; Dela Rosa, Arnold ; Buckley, Sarah ; White, Hayden ; Novy, Emmanuel ; Bhardwaj, Vallish ; Gurr, Lucy ; Bangash, Mansoor ; Westall, Christopher ; Frouin, Antoine ; Furborough, Erin ; Fernandez, Ziortza ; Corcoran, Ele ; Thanasi, Maria ; Kirk, Jill ; Lorah, Shelley ; Joosten, Anne ; Winter, Karen ; Sunkara, Krishna ; Billot, Laurent ; Wilkinson, Conor ; Bland, Yvonne ; Tatham, Kate ; Brinkerhoff, Gail ; Ali, Farisha ; Matthews, Laura ; Van Hecke, Jolien ; Farnell Ward, Sarah ; Verula, Jerik ; Patel, Jaimin ; Conner, Louise ; Ahmed, Iram ; Finney, Clare ; Hennessy, Immanuel ; Furness, Hugh ; Crowe, Rebecca ; Brown, Janette ; Larsson, Marina ; Affleck, Julia ; Kelty, Amy ; Spruce, Elaine ; Paterson, David L. ; Bradshaw, Zena ; McAllister, Rick ; Griffin, Denise ; Jewitt, Chelcie ; Collins, Emma ; Spencer, Craig ; Preston, Charlotte ; Dent, Martin ; Lipman, Jeffrey ; Simmonds, Catherine ; Carta, Sabrina ; Luciuk, Magdalena ; Doyle, Sarah ; Barraclough, Lauren ; Peck, Leah ; Yun, Nikki ; Duroux, Maree ; Bush, Dustin ; Woollett (now Robertson), Melissa ; Wells, Colin ; Alborzi, Maryam ; Smith, Tracy ; Matumikina, Nancy ; Omar, Mahamarowi ; Mead, Victoria ; Elawamy, Lisa ; Rouse, Stephanie ; Smellie, Hannah ; Greenshields, Nicole ; Keehan, Mary ; Mason, Tracy ; McNicholas, James ; Garland, Zoe ; Jane, April ; Miller, Jennene ; Latimer-Bell, Charlotte ; Alvarez Corral, Maria ; Sturland, Shawn ; Naik, Kshiteeja ; Hanks, Fraser ; Mckay Vucago, Agnes ; Bolger, Clare ; Fahey, Alan ; Lesona, Eden ; Othman Jailani, Mohamad Irfan ; Reschreiter, Henrik ; Raobaikady, Ravishankar ; Wills, Alasdair ; Mat Amin, Md Fadhil ; Van Cutsem, Maxime ; Brown, Gemma ; Clark, Amy ; Nair, Renesh ; McLaren, Ruth ; Ryan, Samantha ; Mazlan, Mohd Zulfakar ; Montaser, Rugaia ; Mohd Sukri, Nabila ; Horton, Sarah ; Major, Amy ; Domingo, Dovy ; Brooks, Jenny ; Roffe, Suzanne ; Dyett, John ; Hallion, Jane ; De Smeytere, Anouska ; Kajtor, Istvan ; Taylor, Colman ; Gill, Mandy ; Ellis, Chiara ; Cusack, Rebecca ; Judd, Harriet ; Pocock, James ; Cupitt, Jason ; Hamilton, Charlene ; Beach, Delores ; Bartley, Shauna ; Wood, James ; Carveli, Paula ; Tokumitsu, Miyuki ; Sowah, Sandra ; Davis, Joshua S. ; Rose, Alistair ; Hasan, Mohd Shahnaz ; Jagannathan, Vijay ; Franke, Uwe ; McGuinness, Niki ; Biradar, Vishwanath ; Kaufman, Melissa ; Newton-Cox, Alex ; Soar, Natalie ; Nelderup, Maria ; Chmielewska, Sandra ; Annborn, Martin ; Anderson, Susan ; Morgan, Matt ; Chen, Yan ; Coles, Jennifer ; Tietjens, Kate ; D’Amato, Fabiola ; Clayton, Matt ; Poulter, Amber-Louise ; Gatward, Jonathan ; Salerno, Tania ; Miln, Rebecca ; Adams, Nikkita ; Gray, Geraldine ; Williams, Tony ; Ding, Lijun ; Rees, James ; Iles, Simon ; McCooey, Jazmine ; Hussain, Nauman ; Mohammed, Amal ; Johnson, Rebekah ; Morris, Lucy ; Moschietto, Sébastien ; Saylor, Emma ; Wilson, Katie ; Clarey, Emma ; Kabungo, Pamela ; McConnochie, Rachael ; Cheng, Andrew ; Joy, Jenyfer ; Schrey, Susann ; Depante, Maria ; Efford, Georgia ; Tabah, Alexis ; Jackson, Sophie ; Nour, Razan ; Bonnefoy, Marie ; Cruysberghs, Kaatje ; Hill, Helen ; Hendry, Deb ; Dugh, Parveen ; Cotta, Menino O. ; Ahmadnia, Ehsan ; Lawrence, Cassie ; Duke, Graeme ; Sloan, Brendan ; Jenkins, Sarah ; Wilson, Laurence ; Kong, Jing ; Remmington, Chris ; Dare, Oliver ; Boyd, Elizabeth ; Stowe, Bethan ; Hawkins, Carl ; Hugill, Keith ; Harrop, Clare ; Turner, Kate ; Herdman-Grant, Rosaleen ; Templeton, Maie ; Grimmer, Lisa ; Salmon, Karen ; Bracke, Stephanie ; Sara, Treena ; Ramanan, Mahesh ; Walton, Catherine ; Coe, Ryan ; Kadirvelarasan, Ahalya ; Cole, Jade ; Reynolds, Claire ; Butler, Lauren ; Van Damme, Annelies ; Tamang Gurung, Anita ; Harward, Meg ; Radhakrishnan, Jayachandran ; Ross, Melanie ; Morrison, Lynette ; Walker, Lawrence ; Shanmugasundaram, Pradeep ; Andrews, Eleanor ; Kamundi, Charlotte ; Millington, Alex ; Tuan Mohd Adnan, Tuan Zulfadli Syazwan ; Van Der Heyden, Kym ; Saxena, Manoj ; Cornell, Sarah ; Cattigan, Claire ; Hankinson, Shamina ; Srilastava, Prakhar ; Kirk-Bayley, Justin ; Davies, Michelle ; Hopkins, Philip ; Squires, Rebecca ; Webber, Sophie ; Austin , Pauline ; Taccone, Fabio ; Wickett, Jos ; Pallas, Naomi ; Pogreban, Tatiana ; Shelley, Ben ; Sutherland, Sara Beth ; Rajbhandari, Dorrilyn ; Cathcart, Susanne ; Foster, Louise ; Glazebrook, Tessa ; Lumby, Cat ; Khalid, Mariha ; Antcliffe, David ; Edwards, Luke ; Che Omar, Sanihah ; Martinson, Victoria ; Tanna, Shamil ; Hayden, Paul ; Ofori, Linda ; Young, Chelsea ; Durand, Dominique ; Page, Valerie ; Alayan, Ali ; Hammond, Naomi E. ; Fellows, Emma ; Inskip, Deborah ; Boyer, Naomi ; Harris, Roger ; Dooley, Natalie ; Jelbart, Brie ; Leaver, Susannah ; Delaney, Kirsha ; Bartholomew, Sarah ; Abbenhuijs, Caroline ; Bacciarelli, Samantha ; Finfer, Simon ; Grayson, Kim ; Martynoga, Robert ; Pyae Soan, Kyaw ; Barnes, Colin ; Phull, Mandeep ; McKie, Hayley ; Parke, Rachael ; De Crop, Luc ; McLaughlan, Danielle ; Thornborough, Lauren ; Hunter, Stephanie ; Fourie, Cheryl ; Gurung Rai, Sabi ; Daly, Zoe ; Noble, Harriet ; Muteitha, Margaret ; Butler, Amelia ; George, Aparna ; Belagodu, Zakaulla ; Myburgh, John A. ; Kirrane, Marianne ; Lim, Rosario ; Davie, Amanda ; Meredith, Megan ; Mupudzi, McDonald ; Morgan, Stacey ; Ocean, Nicola ; Santos, Filipa ; Webb, Zoszka ; Ashcroft, Andrew ; Ali, Hafsana ; O’Connor, Caroline ; Simpson, Kathryn ; Neal, Aoife ; Meye, Jason ; Radcliffe, Gill ; Rojo, Roceld ; Billyward, Thomas ; Warden, Scott ; Hamidi, Mohammad ; Harkett, Samantha ; Jorens, Philippe ; Bociek, Aneta ; Sulaiman, Helmi ; Turner, Elisha ; Roy, Alistair ; Johnston, Rachel ; Vutipongsatorn, Kritchai ; May Sanga, Donna ; Buckley, Julie ; Cooper, Lauren ; Morera, Kyma ; Bemand, Thomas ; Patel, Shivali ; Cottam, Daniel ; Dahyot-Fizelier, Claire ; Ellis, Katrina ; Ismet, Suki ; Burke, Brandon ; Joseph, Mareena ; Barge, Deborah ; Bewley, Jeremy ; Bosompem, Sam ; Forni, Lui ; Phull, Mandeep K ; Cockrell, Maeve ; King, Saffron ; Ashraf, Saima ; Ivin, Nick ; Ruddick, Tracy ; Ventura, Vince ; Agarwal, Sidharth ; Barton, Greg ; Bremmer, Pamela ; Williams, Patricia ; Bevan, Emily ; Barry, Ben ; Burnish, Rachel ; Beehre, Niña ; Swain, Andrew ; Buckley, Hugo ; Trodd, Dawn ; Fiske, Caitriona ; Williams, Angharad ; Sol Cruz, Rhoze ; Lee, Richard ; Grout, Margaret ; Davey, Miriam ; Sherwood, William ; Roslan, Era Nabilah ; Gratrix, Andrew ; Vermeiren, Daisy ; Birch, Janine ; Maese, Sam ; Cotterell, Stacey ; Fernandez, Maria ; John, Sherin ; Shirwadkar, Charudatt ; Baker, Stuart ; Stapleton, Liana ; Ryan, Lucy ; Jamaludin, Noor Iellieya Maisarah ; Ure, Bob ; Dulhunty, Joel M. ; Balcioglu, Julia ; Peters, Cecilia ; Husain, Aatif ; Cameron, Lynda ; Collins, Aimi ; Del Socorro, Jeanny ; Zolfaghari, Parjam ; Willis, Joan ; Vertongen, Petra ; Muchenje, Nycola ; Hammerton, Kate ; Salmuna, Zeti Norfidiyati ; Shone, Sam ; Doyle, Tara ; Manso, Katarina ; De’Ath, Yasmin ; Jacobs, Kylie ; Grewal, Surpreet ; Fowler, Alex ; Breistroff, Jessica ; Webster, Denise ; Thompson, Nicola ; Perin, Nicolas ; Patch, Sarah ; Sousa Arias, Sonia ; Ward, Emma ; Sane, Sunil ; Tahir, Sharjeel ; Arrieta, Amaia ; Tyson, Emma ; Stuart, Carmel ; De Waele, Jan J. ; Holland, Andrew ; Keast, Thomas ; Muller, Laurent ; Diltoer, Marc ; Khyere Diaborr, Thyra ; Nown, Angie ; Summers, Samantha ; McNeela, Fiona ; Bergin, Colin ; Chillingworth, Anna ; Ogbeide, Vonganyi ; Glen, James ; Olatunji, Shaanti ; Janin, Pierre ; Young, Helen ; Banach, Dorota ; Haines, Ryan ; O'Reilly, Kevin ; Claridge, Helen ; Butler, Magdalena ; Bullman, Letitia ; Abrams, Judith ; Neal, Philippa ; Kostencovska, Angela ; Stuart, Janine ; Goundry, Stephanie ; Stones, Elizabeth ; Wilkinson, Jack ; Moore, James ; Jambunathan, Venkateswaran ; Thirifays, Anne ; Gulati, Arti ; Jones, Jessica ; Norris, Isabel ; Supermanian, Sharwend ; Gellie, Kym ; Robertson, Yve ; Warhurst, Timothy ; Mysore, Jayanthi ; Ducq, Pierre ; Jacques, Nicola ; Fannes, Els ; Owens, Amy ; Shelton, Jonathan ; Abdullise, Hanan ; Boström, Lisa ; Ali Abdelhamid, Yasmine ; Clark, Peter ; Puxty, Kathryn ; Pomichowska, Magda ; Gough, Maimoonbe ; Mohamad, Marhainie ; Touzet, Marion ; Cohen, Jeremy ; Gilder, Eileen ; Joseph, Treesa ; Mehta, Reena ; Shuker, Karen ; Boxall, Emma ; Morris, Anna ; Austin, Mandy ; Collins, Katy ; Doherty, Sarah ; Remnant, Sam ; Lai, Vivian ; Thomas, Pete ; Shelton, Sarah ; Grecu, Irina ; Howle, Ryan ; Davis, Megan ; Eastwood, Glenn ; Metcalfe, Alex ; Thomas, Emma ; Williams, Trish ; Iqbal, Sultan ; Barker, Mike ; Colegrove, Melanie ; Ryckaert, Steffi ; Bellomo, Rinaldo ; Langridge, Emma ; List, Abigail ; Cowdrey, Keri-Anne ; Cooper, David ; Thomas, Ruth ; Forrest, Mark ; Starr, Therese ; Ostermann, Marlies ; McConnochie, Bree-Yana ; Pepermans Saluzzio, Romina ; Evetts, George ; Nasser, Tahir ; O’Leary, Ryan ; Savage, Sarah ; Thompson, Amy ; Rose, Steve ; Benham, Leonie ; Sweet, Katie ; Carter, Michael ; Navarra, Leanlove ; Kasmani, Ilkin ; Song, Rima ; Farrah, Helen ; Camsooksai, Julie ; Gordon, Anthony ; Ashelford, Angela ; Hunt, Anna ; Tallott, Mandy ; Trask, Kara ; Wong, Jenny ; Thomas, Anju ; Rhodes, Andrew ; Smith, Sam ; Gaur, Atul ; Robb, Thomas ; Mackay, Josie ; Sicat, Christine ; MacDonald, John ; Kim Wright, Kim ; Purcell, Roslyn ; Alaya, Sami ; McCall, Phil ; Addari, Claudio ; Bradford, Celia ; Dolman, Rozzie ; Poole, Alice ; Houbert, Maree ; Liu, Xiaoqiu ; Lewis, Stephen ; Mofredj, Ali ; Walsham, James ; Boutin, Caroline ; Wyncoll, Duncan ; Delaney, Anthony ; Riedel, Ella ; Rogers, Sarah ; Van Malderen, Marie Claire ; Lau, Luke ; Yates, Bryan ; Faulkner, Maria ; Hines, Matthew ; Tabah, Alex ; Nizar, Nurul Amira ; Sutton, Joanne ; Dukes, Stephanie ; Parker, Luke ; Belveyre, Thibaut ; Kemp, Harriet ; Wetzig, Krista ; Latham, Scott ; Sollesta, Kathryn ; Phillips, Margaret ; Davies, Rhys ; Hoxha, Elvira ; Lassig-Smith, Melissa ; Suryanarayanan, Bhagawathi ; Zhao, Xiaobei ; Oakley, Naomi ; Van Regenmortel, Niels ; Bowen, David ; Smith, Hazel ; Aitken, Christine ; Pilowsky, Julia ; Troth, Laura ; Saint Gilles, Maximilien ; Stedman, Wade ; Martin, Jane ; Sampson, Julia ; Khorshid, Sarah ; Greener, Danni ; Venz, Ellen ; Nayyar, Vineet ; Shortland, Mark ; Shao Foong Chong, Martin ; Reynolds, Jessica ; Ogunwemimo, Olumayowa ; O’Connor, Karina ; Seidu, Fatima ; Elotmani, Loubna ; MacTavish, Pamela ; Paulyn Rosaroso, Lace ; Denis, Elizabeth ; Sol Cuz, Raulle ; Uddin, Ruzena ; Peacock, Georgina ; Bossy, Michele ; Clavier, Audrey ; Rudham, Sam ; Jones, Cassie ; Rayner, Helen ; Veto, Joseph ; Goldsmith, Arthur ; Yarad, Elizabeth ; Roodenburg, Owen ; Poter, Elizabeth ; Elderkin, Tania ; Collins, Rebecca ; Westerman, Tanith ; Musalagani, Robert ; Ma, Louise ; Bell, Stephanie ; Morley, Joanne ; Chikhani, Marc ; Buhr, Heidi ; Burda, Dorota ; Venkatesh, Balasubramanian ; Hilton, James ; Black, Ethel ; Perkins, Lauren ; Andertun, Sara ; Carrera, Ronald ; Knott, Cameron ; Cabrelli, Louise ; Jamet, Angéline ; Wutte, Waldtraud ; W Hassan, W Mohd Nazarudin ; Jepson, Eleanor ; Bakare, Sekina ; Thomas, Benjamin ; Stevenson, Carl ; Loftus, Sarah ; Sjövall, Fredrik ; Cochrane, Anthony ; Mcintosh, Kathryn ; Casey, Matthew ; Smith, John ; Forrest, Annette ; Harvey, Daniel ; Murray, Lynn ; Ito, Asako ; Williams, Simon ; Pratley, Anezka ; Dunn, Leigh ; Smith, Julie ; McArthur, Colin ; Richard, Nicole ; Jhanji, Shaman ; Baker, Alice ; Brett, Stephen J. ; Heerman, Jan ; Smolen, Sue ; Sanap, Milind ; Martin, Rosie ; Mew, Louise ; Cortes, Nicholas J ; Patel, Amee ; Wilson, Eva ; Paul, Pulak ; Yaakub, Halimatun Arwa ; Pollock, Hamish ; Nand, Kiran ; Chimunda, Timothy ; Winearls, James ; Deane, Adam ; Bhuie, Parminder ; Suliman, Adam ; Dolan, Hayley ; Holden, Francesca ; Sheridan, Christopher ; McKerrow, Elizabeth ; Cooper, Melanie ; Tooley, Joe ; Bone, Alison ; De Schryver, Nicolas ; Girijadevi, Dinu ; Sanchez-Rodriguez, Ana ; Kurenda, Catherine ; Jackson, Susan ; Smyth, Kirsty ; Stewart, Richard ; Seaman, Rebecca ; Schischka, Livia ; Balasubramaniam, Madhu ; Gillespie, Marion ; Livermore, Amelia ; Cawley, Kathryn ; Chan, Peter ; Ruttledge, Aine ; Saint Genis, Quentin ; Clark, Michele ; Dinsdale, Dick ; Gordon-Williams, Richard ; Spencer, Kayleigh ; Lant, Suzannah ; Woods, Lindsey ; Mohd Nor, Husna ; Dawson, Nichalus ; Pitman, Julie ; Bradley, Isabel ; McKinley, Jame ; Chapman, Susan ; Knowles, Serena ; McKay, Laura ; Nikitas, Nikitas ; Hunt, Emma ; Chapman, Lianne ; Parekh, Dhruv ; Ratcliffe, Megan ; Doonan, Reece ; Purvis, Sarah ; Dearden, Joy ; Aguilar, April ; Boschert, Catherine ; Rivers, Vanessa ; Mehrtens, Jan ; Byrne, Kathleen ; De Coster, Lesley ; Wright, Jason ; Peake, Sandra ; Gutehrle, Aurélie ; Hambrook, Geraldine ; Thaladi, Natasha ; Hardy, Gareth ; Martin, Tim ; Alauzet, Corentine ; Bierl, Cynthia ; Limbrey, Elizabeth ; Ashton, Anthony ; Bass, Frances ; Ellis, Karen ; Roger, Claire ; Jootun, Robin ; Donovan, Shelley ; Ward, Geraldine ; Lindsay, Daisy ; Voralia, Shree ; Stoddard, Emma ; Mahul, Martin ; Mar, Sharon ; Gattas, David

ImportanceWhether β-lactam antibiotics administered by continuous compared with intermittent infusion reduces the risk of death in patients with sepsis is uncertain.ObjectiveTo evaluate whether continuous vs intermittent infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) results in decreased all-cause mortality at 90 days in critically ill patients with sepsis.Design, Setting, and ParticipantsAn international, open-label, randomized clinical trial conducted in 104 intensive care units (ICUs) in Australia, Belgium, France, Malaysia, New Zealand, Sweden, and the United Kingdom. Recruitment occurred from March 26, 2018, to January 11, 2023, with follow-up completed on April 12, 2023. Participants were critically ill adults (≥18 years) treated with piperacillin-tazobactam or meropenem for sepsis.InterventionEligible patients were randomized to receive an equivalent 24-hour dose of a β-lactam antibiotic by either continuous (n = 3498) or intermittent (n = 3533) infusion for a clinician-determined duration of treatment or until ICU discharge, whichever occurred first.Main Outcomes and MeasuresThe primary outcome was all-cause mortality within 90 days after randomization. Secondary outcomes were clinical cure up to 14 days after randomization; new acquisition, colonization, or infection with a multiresistant organism or Clostridioides difficile infection up to 14 days after randomization; ICU mortality; and in-hospital mortality.ResultsAmong 7202 randomized participants, 7031 (mean [SD] age, 59 [16] years; 2423 women [35%]) met consent requirements for inclusion in the primary analysis (97.6%). Within 90 days, 864 of 3474 patients (24.9%) assigned to receive continuous infusion had died compared with 939 of 3507 (26.8%) assigned intermittent infusion (absolute difference, −1.9% [95% CI, −4.9% to 1.1%]; odds ratio, 0.91 [95% CI, 0.81 to 1.01]; P = .08). Clinical cure was higher in the continuous vs intermittent infusion group (1930/3467 [55.7%] and 1744/3491 [50.0%], respectively; absolute difference, 5.7% [95% CI, 2.4% to 9.1%]). Other secondary outcomes were not statistically different.Conclusions and RelevanceThe observed difference in 90-day mortality between continuous vs intermittent infusions of β-lactam antibiotics did not meet statistical significance in the primary analysis. However, the confidence interval around the effect estimate includes the possibility of both no important effect and a clinically important benefit in the use of continuous infusions in this group of patients.Trial RegistrationClinicalTrials.gov Identifier: NCT03213990

01 Aug 2024·International Journal of Sports Science & Coaching

Menstrual cycle characteristics, hormonal contraceptive use and perceptions of related effects in resistance-trained athletes

Author: Harris, Nigel ; SantaBarbara, Kimberly ; Armour, Mike ; Helms, Eric

There has been an increased interest in the effects the menstrual cycle (MC) may have on sports performance. As a part of the MC, many females experience a wide range of symptoms related to hormonal fluctuations and menstrual bleeding, including physical pain and mood disturbances. Currently, there is a lack of data on the MCs of females who participate in resistance training. The dearth of information on the regular MC in female athletes may lead to poorly informed training recommendations which may be detrimental for female athletic advancement. The purpose of this survey was to determine the average MC characteristics, hormonal contraceptive (HC) use and perceived effects of the MC on training in resistance-trained athletes, and to determine if there are differences in these variables when comparing recreationally trained women to competitive-level athletes. A survey addressing questions about the MC, HC use and perceived effects of the MC was accessed by 906 participants who self-identified as resistance-trained athletes. Resistance-trained athletes, competitive or not, experience MCs similar to data on other exercising females and the general population. MC symptoms are widespread and, for some, can be quite severe and limiting. Competitive athletes were not more likely to experience MC irregularities than non-competitive females. Nearly half of the participants reported using HCs. Most participants perceived that their MC had a negative effect on their performance and that their MC caused reductions in training load or workout program adherence, although most competitive-level athletes did not withdraw from competitions due to MC symptoms.

01 Aug 2024·Journal of Allergy and Clinical Immunology: Global

Patterns of asthma medication use and hospital discharges in New Zealand

Article

Author: Weatherall, Mark ; Hatter, Lee ; Noble, Jonathan ; Hills, Thomas ; Beasley, Richard ; Bruce, Pepa ; Bean, Orlagh ; Eathorne, Allie

BackgroundIn New Zealand a progressive increase in budesonide/formoterol dispensing, accompanied by a reduction in dispensing of short-acting β₂-agonists (SABAs), inhaled corticosteroids (ICSs), and other ICS/long-acting β₂-agonists (ICSs/LABAs), occurred in the 18-month period following publication of the 2020 New Zealand asthma guidelines, which recommended budesonide/formoterol anti-inflammatory reliever therapy.ObjectiveOur aim was to investigate more recent trends in asthma medication use and asthma hospital discharges in New Zealand.MethodsNew Zealand national dispensing data for inhalers for the period from January 2010 to December 2022 were reviewed for patients aged 12 years and older. Monthly rates of dispensing of budesonide/formoterol, ICSs, other ICS/LABAs, and SABAs were displayed graphically by locally weighted scatterplot smoother plots. The rates of dispensing and hospital discharge for asthma were compared between the past 6 months for which dispensing data were available (July-December 2022) and the corresponding period from July to December 2019.ResultsThere has been a progressive increase in dispensing of budesonide/formoterol since 2019, with a 108% increase between the period from July to December 2019 and the period from July to December 2022 in adolescents and adults. In contrast, there was a reduction in rates of dispensing of other ICS/LABAs, ICSs, and SABAs by 3%, 18%, and 5%, respectively. During this period, there was a 17% reduction in hospital discharges for asthma.ConclusionThere has been a further widespread uptake of ICS/formoterol reliever and/or maintenance therapy in adolescents and adults with asthma in New Zealand. The changes in prescribing practice have been temporally associated with a reduction in hospital admissions for asthma.

100 Deals associated with Medical Research Institute of New Zealand

100 Translational Medicine associated with Medical Research Institute of New Zealand

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