Delving into the Latest Updates on Jubilant Therapeutics India Ltd. with Synapse

Overview

A Phase 1, Multicenter, Open-Label, Dose-Escalation/Consolidation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Orally Administered JBI-778 in EGFR Mutated Lung Cancer Patients with or without Brain Metastasis, Isocitrate Dehydrogenase (IDH) Mutated WHO Grade 3/4 Recurrent Glioma and Adenoid Cystic Carcinoma (ACC) - Nil

Start Date26 Aug 2024

Sponsor / Collaborator

Jubilant Therapeutics India Ltd.

100 Clinical Results associated with Jubilant Therapeutics India Ltd.

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0 Patents (Medical) associated with Jubilant Therapeutics India Ltd.

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1

Literatures (Medical) associated with Jubilant Therapeutics India Ltd.

01 Feb 2021·Bioorganic & Medicinal Chemistry LettersQ4 · MEDICINE

Novel dual LSD1/HDAC6 inhibitors for the treatment of multiple myeloma

Q4 · MEDICINE

Article

Author: Zainuddin, Mohd ; Rajagopal, Sridharan ; Chickamunivenkatappa, Srinatha ; Gajendran, Chandru ; Naveen Sadhu, M ; Tantry, Subramanyam ; Sivanandhan, Dhanalakshmi ; Vaithilingam, Krishnakumar ; Dewang, Purushottam ; Murugan, Kannan ; Nair, Sreekala

Lysine specific demethylase 1 (LSD1) and HDAC6 are epigenetic proteins associated with several diseases, including cancer and combined inhibition of these proteins could be highly beneficial in treating some cancers such as AML, MM and solid tumors. Multiple myeloma (MM) is a challenging cancer with fast relapse rate where novel treatment options are the need of the hour. We have designed and developed novel, LSD1 and HDAC6 selective dual inhibitors to target MM. Our dual inhibitor compound 1 shows superior potency in multiple MM cell lines. In MM.1S xenograft model compound 1 shows superior efficacy compared to single agent LSD1 and HDAC6 inhibitors by oral administration and is well tolerated. Further evaluation of the molecule in other cancers is in progress.

100 Deals associated with Jubilant Therapeutics India Ltd.

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100 Translational Medicine associated with Jubilant Therapeutics India Ltd.

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