Delving into the Latest Updates on Qidong Gaitianli Medicines Co., Ltd. with Synapse

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AbstractAlthough striking effects of vaccination strategy against COVID-19 world-wide, a long-term influence by sequential viral mRNA injections are unknown. We analysed biological alterations by total RNA sequencing in Pfizer-BioNTech vaccinated normal healthy volunteers and cancer patients, with or without adjuvant Huaier therapy. A significant destruction in ribosomal RNA structures was identified, enhanced by serial shots. Unlike the destruction caused by chemotherapy with platinum (II) complex, progressive destruction in 18S ribosome was identified even at 6 months after vaccination. The influence resulted in massive inhibition of translation and transcription, significantly in intra/inter neural signaling transfer and in lipid metabolism, related to ageing process. Huaier compensated these dysfunctions by miRNA-mediated transcriptional control, by typical activation in PI3K/AKT signaling pathway. Gene Ontology analysis revealed spontaneous virion production in number even after 3 months of the first vaccination. Present study indicated that the adjuvant therapy like Huaier compensates accelerated ageing process by mRNA vaccination.

Zhongguo Yiyao Gongye Zazhi

Determination of ferulic acid in Qiying Yuyang granules by HPLC

Author: Li, Zhenqiang ; Wu, Feng

The HPLC method for the determination of ferulic acid in Qiying Yuyang granules was presented.The YWG C₁₈ column was used with the mobile phase of methanol-0.066M Na₂HPO₄ solution (pH 2.5, adjusted by H₃PO₄) (40:60).The flowing rate was 1.00 mL min^-1 and the detection wavelength was 320 nm.The calibration curve was linear in the range of 0.08-0.32 μg, and the average recovery was 98.9% with RSD of 1.54%.

Extensive genomic plasticity identified by anti-cancer Huaier therapy

Author: Xu, Chenying ; Luo, Zhu ; Lin, Hong ; Wei, Ding ; Tanaka, Manami ; Li, Ning ; Teng, Fei ; Tanaka, Tomoo ; Lu, Zhengxin

AbstractClinical significance of anti-cancer effects of Huaier has been emphasized recently. We have proved that a broad spectrum of Huaier effects was based on the rescue of the disrupted Hippo signalling pathway, especially through the rescue of transcriptional dysregulation. We initiated clinical research for thorough understanding of mode of action by total RNA- and small non-coding RNA-sequencing. Here we provide the surprising genomic plasticity by Huaier observed in the time course of recovery from cancer. The extensive changes in RNA editing events were first observed, such as average 92,427 SNP variances per individual (22,688 in normal control). The subsequent changes in the process of translation and transcription resulted in the drastic changes in number of up/down-regulated transcripts. The ratio of the changes at maximum was 85% (23,210/27,447). With the advent of many novel sequences found in small nuclear RNAs and the consequent gene-silencing derived from miRNA-mediated post-transcriptional control, quantitative and qualitative changes of expression in transcriptional factors (mean 1,115/person) contributed to rescue dysregulated functions occurred in almost all required physiological functions for cancer recovery. The transcription control was demonstrated as functional lineage map between the core transcriptional factor and functionally linked transcripts, and the recovery could be clearly shown as the silencing of those massive changes in the end. The genetic alterations, especially related to the inhibition of NFκB and TGF-β signalling pathways showed significant effects on the improvement of prognosis. Thus, Huaier therapy contributes to cancer cell death with damaged tissue regeneration by extensive and systematic genomic modulations.

100 Deals associated with Qidong Gaitianli Medicines Co., Ltd.

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100 Translational Medicine associated with Qidong Gaitianli Medicines Co., Ltd.

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Pipeline

Pipeline Snapshot as of 23 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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