BioVex Ltd.

March 10, 2026 / Today Technomark Life Sciences and MAX BioPharma announced their collaboration in the development of MAX BioPharma's oxysterol drug candidate, Oxy210, for targeting metabolic dysfunction-associated steatohepatitis (MASH). As a strategic lead investor, Technomark is investing in MAX BioPharma by participating in its $13 million Series A raise to initiate and complete a Phase 1a/1b first-in-human study and invites aligned investors from the industry to join this opportunity. "We are extremely excited about forming this important collaboration that will empower MAX BioPharma in its efforts to develop a safe, effective, orally bioavailable, novel therapy, derived from our Oxysterol Therapeutics® platform, for targeting MASH. We anticipate that through its potent antifibrotic and anti-inflammatory properties, Oxy210 will have a robust impact on the more effective management of those suffering from MASH, and most likely its more advanced form that involves liver scarring (cirrhosis). Forming a strategic partnership with Technomark serves as a significant milestone, and we invite other investors to join us and complete this Series A raise" says Farhad Parhami, President and CEO of MAX BioPharma. Frank Stappenbeck, Director of Chemistry at MAX BioPharma adds: "There is a need for safe and cost-effective treatment options for MASH, not only in the US, but worldwide. Compared to existing drugs and drug candidates for MASH, Oxy210 can be scaled at low cost using inexpensive materials via straightforward chemical synthesis. And, as a small molecule stable at room temperature, Oxy210 would not need a cold supply chain, as required for peptide-based GLP-1 agonists, for example." Dr. Scott Friedman, Professor of Medicine and Director of Institute for Liver Research at the Icahn School of Medicine at Mount Sinai explains: "By hitting several of the core disease drivers at once, i.e. inflammation, fibrosis, senescence, and metabolic dysfunction with oral dosing and clean preclinical data thus far, Oxy210 can have a meaningful impact on MASH. If these preclinical findings translate into humans, Oxy210 has the pro a novel, disease‑modifying agent that could be used alone or in combination with metabolic agents (e.g., GLP‑1 agonists) to target both liver fibrosis and cardiometabolic vulnerabilities". Allen Hakimi, CEO and Managing Director of Technomark states: "We are enthusiastic about our collaboration with MAX BioPharma and the value that we can add to its already impressive therapeutic development program by providing our decades long experience in navigating the often complex tasks in drug development, to bring a much-needed therapy for people with MASH, while creating maximum value for stakeholders." MAX BioPharma is a privately held preclinical stage California-based biopharmaceutical company developing novel small molecule lipids as drug candidates for intervention in debilitating and fatal human diseases. The company will be a leader in a new field of Oxysterol Therapeutics® by leveraging a robust and growing intellectual property portfolio that will lead to treatments for numerous indications. With many potential opportunities in its pipeline, MAX BioPharma is focused on the development of its lead asset, Oxy210, an orally bioavailable antifibrotic and anti-inflammatory proprietary oxysterol for targeting MASH and other fibrotic diseases. The company is currently raising a $13M tranche Series A financing while searching for strategic partners to move Oxy210 through Phase 1 clinical trials for MASH. Technomark Life Sciences is a 38 year old venture capital group. Technomark contributes by cofunding/investing in the cost of the development program (clinical study or GLP Tox study costs) on a risk sharing basis (30-60%). Technomark's investment track record includes the $1 billion BioVex Limited exit to Amgen (2011) and achieving a 68% success rate on clinical programs in which it has invested over a 38-year period. We are excited to welcome MAX BioPharma into our growing family of breakthrough innovators. The content above comes from the network. if any infringement, please contact us to modify.

Over the last ten years, cell-based immunotherapy has emerged as a promising approach for treating solid tumors. Several companies, including Iovance Biotherapeutics, Obsidian Therapeutics, Biosyngen, KSQ Therapeutics, and others, are currently engaged in the development and production of TIL therapies, which have the potential to significantly impact and enhance the TIL therapies market. LAS VEGAS, Aug. 12, 2025 /PRNewswire/ -- DelveInsight's Tumor-Infiltrating Lymphocyte Therapies Market Size, Target Population, Competitive Landscape & Market Forecast report includes a comprehensive understanding of current treatment practices, addressable patient population, which includes top indications such as melanoma, cervical cancer, non-small cell lung cancer (NSCLC), endometrial cancer, head and neck squamous cell carcinoma (HNSCC), colorectal cancer, and other solid tumors. The selected indications are based on approved therapies and ongoing pipeline activity. The report also provides insights into the emerging tumor-infiltrating lymphocyte therapies, market share of individual therapies, and current and forecasted market size from 2020 to 2034, segmented into 7MM. Key Takeaways from the Tumor-Infiltrating Lymphocyte Therapies Market Report As per DelveInsight's analysis, the total market size of tumor-infiltrating lymphocyte therapies in the 7MM is expected to surge significantly by 2034. The report provides the total potential number of patients in the indications, such as melanoma, cervical cancer, non-small cell lung cancer (NSCLC), endometrial cancer, head and neck squamous cell carcinoma (HNSCC), colorectal cancer, and other solid tumors. Leading tumor-infiltrating lymphocyte therapies companies, such as Obsidian Therapeutics, Biosyngen, KSQ Therapeutics, and others, are developing novel tumor-infiltrating lymphocyte therapies that can be available in the tumor-infiltrating lymphocyte therapies market in the coming years. Some of the key tumor-infiltrating lymphocyte therapies in the pipeline include OBX-115, BST02, KSQ-001 EX, KSQ-004 EX, and others. In June 2025, Iovance Biotherapeutics announced that the Journal of Clinical Oncology has published the final analysis from the Phase II C-144-01 clinical trial evaluating the individualized T cell therapy AMTAGVI in patients with advanced melanoma. These five-year follow-up results are being simultaneously presented during an oral session today at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting. In June 2025, Obsidian Therapeutics announced initial Phase I safety and efficacy data from the Phase I/II Agni-01 multicenter study of OBX-115 a summarized the data will be presented by the Director and Chief Administrative Officer of UofL Health – Brown Cancer Center/Oncology Service Line at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting. In April 2025, KSQ Therapeutics announced the first patient dosed in the Phase I/II clinical study of KSQ-004EX, a novel CRISPR-engineered Tumor Infiltrating Lymphocyte (eTIL) therapy. KSQ-004EX consists of eTIL in which the SOCS1 and Regnase-1 genes are inactivated by CRISPR/Cas9 gene editing, giving it the potential to be a best-in-class treatment for a variety of solid tumor indications. KSQ's CRISPRomics platform identified SOCS1 and Regnase-1 as key genes inhibiting the ability of TIL to eradicate solid tumors in preclinical models. Discover which indication is expected to grab the major tumor-infiltrating lymphocyte therapies market share @ Tumor-Infiltrating Lymphocyte Therapies Market Report Tumor-Infiltrating Lymphocyte Therapies Market Dynamics The tumor-infiltrating lymphocyte therapies market is poised for transformative growth, driven by increasing interest in personalized and cell-based immunotherapies for solid tumors. The market gained significant momentum following the U.S. FDA approval of Iovance Biotherapeutics' AMTAGVI in 2024 for advanced melanoma, marking the first regulatory validation of a TIL therapy and paving the way for wider clinical adoption and investor confidence. A major driver of the market is the growing unmet need in solid tumor treatment, where conventional immunotherapies like checkpoint inhibitors have limited efficacy for many patients. TIL therapies offer a more tailored solution, capable of overcoming tumor immune evasion by targeting multiple neoantigens. Advances in cell manufacturing, automation, and closed-system bioprocessing are also contributing to improved scalability and reduced turnaround times, addressing one of the historic limitations of TILs, the complex and time-intensive production process. The competitive landscape is becoming increasingly dynamic, with numerous biotechnology firms and academic institutions entering the TIL space. Strategic partnerships, technology licensing, and mergers & acquisitions are prevalent as players aim to build robust manufacturing capabilities and differentiate their platforms using gene editing, selection techniques, or combination regimens with checkpoint inhibitors. However, the market faces several challenges, including high production costs, patient-specific manufacturing logistics, and the need for specialized infrastructure. Reimbursement hurdles, regulatory complexities, and the need for biomarker-based patient selection also represent significant barriers to widespread commercialization. Nonetheless, continued progress in artificial intelligence for neoantigen identification, cryopreservation methods, and decentralized manufacturing models could mitigate many of these issues over time. In conclusion, the TIL therapies market is at an inflection point, transitioning from early-stage development to commercial viability. The combination of strong clinical data, regulatory tailwinds, and technological innovation is expected to drive robust growth in the coming decade. As more TIL therapies move into late-stage trials and receive regulatory approval, their role in the broader oncology treatment landscape is likely to expand, especially for cancers with high unmet needs and limited therapeutic options. Tumor-Infiltrating Lymphocyte Therapies Treatment Market TIL therapies represent a new generation of personalized immunotherapy designed to leverage a patient's own immune system to combat solid tumors. This approach involves extracting TILs from a patient's tumor, expanding and modifying them outside the body, and then reinfusing them to stimulate a targeted immune response. After years of academic research, the field reached a significant milestone in 2024 with the FDA approval of AMTAGVI by Iovance Biotherapeutics for treating advanced melanoma. AMTAGVI is an autologous T cell therapy derived from a patient's tumor, approved for adult patients with unresectable or metastatic melanoma who have previously received a PD-1 inhibitor. For those with a BRAF V600 mutation, prior treatment with a BRAF inhibitor, with or without a MEK inhibitor, is also required. Although its exact mechanism of action is not fully understood, AMTAGVI is believed to work by utilizing the patient's own TILs. These TILs naturally develop in response to cancer and are capable of recognizing and attacking tumor-specific markers. However, as cancer progresses, the effectiveness of these native TILs diminishes. AMTAGVI seeks to restore and enhance its function by reintroducing activated TILs into the patient. The therapy is also being evaluated in late-stage clinical trials, both as a standalone treatment and in combination with pembrolizumab, for other cancers such as non-small cell lung cancer and cervical cancer. Learn more about the tumor-infiltrating lymphocyte therapies @ Tumor-Infiltrating Lymphocyte Therapies Analysis Key Emerging Tumor-Infiltrating Lymphocyte Therapies and Companies TIL therapies have a pipeline, with candidates such as O BX-115, BST02, KSQ-001 EX, and KSQ-004 EX in early Phase (I/II) trials targeting diverse indications like advanced gastric, gastroesophageal junction, and other solid tumors. OBX‑115 is an advanced tumor-infiltrating lymphocyte (TIL) therapy developed using Obsidian's proprietary cytoDRIVE platform. This therapy involves genetically modifying TILs to express membrane-bound interleukin-15 (mbIL‑15), which enhances T cell proliferation, durability, and antitumor effectiveness—eliminating the need for high-dose IL‑2, a key source of toxicity in traditional TIL therapies. The OBX‑115 TILs are engineered to produce mbIL‑15 linked to a drug-responsive domain, enabling controlled, dose-dependent increases in mbIL‑15 levels when an FDA-approved stabilizing agent, acetazolamide (ACZ), is administered. This approach further removes the requirement for IL‑2. In September 2024, Obsidian Therapeutics announced that the U.S. FDA granted OBX‑115 Regenerative Medicine Advanced Therapy (RMAT) designation for treating patients with unresectable or metastatic melanoma that no longer responds to immune checkpoint inhibitors (ICIs). The anticipated launch of these emerging therapies are poised to transform the tumor-infiltrating lymphocyte therapies market landscape in the coming years. As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the tumor-infiltrating lymphocyte therapies market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth. To know more about tumor-infiltrating lymphocyte therapies clinical trials, visit @ Tumor-Infiltrating Lymphocyte Therapies Treatment Tumor-Infiltrating Lymphocyte Therapies Overview Tumor-infiltrating lymphocyte (TIL) therapy is an advanced type of adoptive cell therapy (ACT) that involves isolating naturally occurring, polyclonal T cells from within a patient's tumor microenvironment, expanding them outside the body, and reintroducing them after the patient undergoes non-myeloablative lymphodepletion. Unlike engineered approaches such as CAR-T or TCR therapies, TIL therapy leverages the natural tumor-targeting ability of the patient's own T cells, which are already primed to detect a broad range of tumor-specific neoantigens. The strategy is based on the idea that these tumor-resident T cells can generate a more effective and biologically relevant immune response. Once infused back into the patient, the expanded TILs can survive, home in on tumor sites, and exert cytotoxic effects on cancer cells. This approach has shown lasting clinical responses, especially in immunologically active cancers like metastatic melanoma, cervical cancer, and non-small cell lung cancer (NSCLC), including in cases resistant to immune checkpoint inhibitors. Tumor-Infiltrating Lymphocyte Therapies Epidemiology Segmentation The tumor-infiltrating lymphocyte therapies market report proffers epidemiological analysis for the study period 2020–2034 in the 7MM, segmented into: Total Cases of Selected Indications for TIL Therapies Total Eligible Patients of the Selected Indications of TIL Therapies Total Treated Cases in Selected Indications for TIL Therapies Scope of the Tumor-Infiltrating Lymphocyte Therapies Market Report Tumor-Infiltrating Lymphocyte Therapies Therapeutic Assessment: Tumor-Infiltrating Lymphocyte Therapies' current marketed and emerging therapies Tumor-Infiltrating Lymphocyte Therapies Market Dynamics: Conjoint Analysis of Emerging Tumor-Infiltrating Lymphocyte Therapies Drugs Competitive Intelligence Analysis: SWOT analysis and Market entry strategies Unmet Needs, KOL's views, Analyst's views, Tumor-Infiltrating Lymphocyte Therapies Market Access and Reimbursement Discover more about tumor-infiltrating lymphocyte therapies in development @ Tumor-Infiltrating Lymphocyte Therapies Clinical Trials Table of Contents Related Reports Non-Small Cell Lung Cancer Market Non-Small Cell Lung Cancer Market Insights, Epidemiology, and Market Forecast – 2034 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key NSCLC companies, including AstraZeneca, Boehringer Ingelheim, Takeda, Johnson & Johnson Innovative Medicine, Eli Lilly and Company, Merck, Bristol-Myers Squibb, Roche, Shanghai Henlius Biotech, AbbVie, Daiichi Sankyo, Nuvation Bio, PDC*line Pharma, Moderna Therapeutics, Pfizer, GSK, Gilead Sciences, BieGene, Nuvalent, among others. 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Newly Appointed Board Chair, Philip Astley-Sparke, Brings Transatlantic Late-Stage Development, Regulatory and Commercial Expertise Strengthened Leadership and Expanded U.S. Presence Positions SynOx for Regulatory Filings and Commercialization of Emactuzumab for Tenosynovial Giant Cell Tumours (TGCT) DUBLIN, Ireland and OXFORD, United Kingdom, April 01, 2025 (GLOBE NEWSWIRE) -- SynOx Therapeutics Limited (“SynOx”), a late-stage clinical biopharmaceutical company developing of emactuzumab for Tenosynovial Giant Cell Tumours (TGCT), today announced the execution of a planned and orderly transition of its board chair position. Philip Astley-Sparke has been appointed as new chair of the board of directors, reflecting SynOx’s ongoing evolution into a global, commercially focused biotechnology company. Mr. Astley-Sparke succeeds Ton Logtenberg, who has served as board chair since 2021, overseeing the company’s growth into a well-funded, late-stage clinical company. With its Phase 3 registrational trial of emactuzumab in TGCT underway, SynOx has evolved its strategic focus to prioritize global regulatory filings, commercial readiness and increasing its transatlantic footprint. This builds upon recent corporate milestones including the raising of a $92 million Series B round of funding and the ongoing build-out of its US executive leadership team. “Ton has been a steady and invaluable partner through a critical period of growth and maturation for SynOx and we are deeply indebted to him for his leadership over the past several years,” said Ray Barlow, Chief Executive Officer of SynOx Therapeutics. “As we embark on our next phase focused on regulatory and commercial activities, we are happy to welcome Philip as our new board chair. His proven experience leading late-stage, transatlantic companies and guiding assets through regulatory approval and launch preparedness will be pivotal as we prepare for the potential commercialization of emactuzumab.” Mr. Astley-Sparke is a seasoned biotechnology executive with a distinguished track record in building and leading innovative companies across immuno-oncology and rare diseases. With over two decades of experience, he has successfully guided multiple organizations from early-stage through to BLA filing with the United States Food and Drug Administration (FDA) and accompanying commercial launch preparations. He has raised over $1.5 billion in capital and held key leadership roles at Replimune Group Inc, where he currently serves as Executive Chairman, uniQure N.V, and BioVex Group Inc. Notably, at BioVex he played a central role in the development of the first FDA-approved oncolytic virus and oversaw a $1 billion acquisition by Amgen. Mr. Astley-Sparke provides SynOx deep expertise in transatlantic biotech operations, in-house manufacturing scale-up, execution of initial public offerings (IPOs), and strategic growth. About Tenosynovial Giant Cell Tumour (TGCT) Tenosynovial Giant Cell Tumour (TGCT), previously termed pigmented villonodular synovitis (PVNS), is a type of tumour that affects the soft tissue lining of joints and tendons. TGCTs are categorised as fibrohistiocytic tumours by the WHO classification and are subclassified based on growth patterns (localised and diffuse types) and location (tendon sheath, intra- and extra-articular forms). TGCTs are locally destructive and can be aggressive. The disease causes significant joint pain, stiffness, loss of function and reduced quality of life. While most patients undergo surgery, more than 50% of those with diffuse TGCT experience tumour recurrence within three years. If left untreated, TGCT can cause joint deformity, degenerative changes, and even lead to arthrodesis or amputation in severe cases. About CSF-1 and Emactuzumab CSF-1 (or macrophage colony-stimulating factor) is a cytokine that binds to the CSF-1 receptor (CSF-1R), expressed on macrophages and other immune cells. Emactuzumab is a humanised IgG1 monoclonal antibody targeting CSF-1R, designed to inhibit and deplete macrophages in tumour tissue. Originally developed by Roche, emactuzumab has shown substantial efficacy in clinical studies in TGCT, including an objective response rate of ~71%, rapid tumour reduction, functional improvement, and good tolerability with a manageable safety profile. Emactuzumab may also have utility in other macrophage-driven diseases, and SynOx is actively exploring further development opportunities in these areas. SynOx recently announced the initiation of the TANGENT study, a global, multi-centre, randomized, double-blind, placebo-controlled Phase 3 trial designed to evaluate the efficacy and safety of emactuzumab in patients with TGCT. Additional study details can be found on ClinicalTrials.gov (Identifier: NCT05417789). About SynOx TherapeuticsSynOx Therapeutics Limited is a Dublin and Oxford-based, late-stage clinical biopharmaceutical company developing emactuzumab, a best-in-class monoclonal antibody against CSF-1R, for the treatment of Tenosynovial Giant Cell Tumour (TGCT) and other CSF-1-related and macrophage-driven disorders. SynOx is led by an experienced team of industry professionals with a successful track record of developing and bringing products to commercialization. The company is backed by a strong syndicate of premier life science investors including Forbion, HealthCap, Bioqube Ventures, Medicxi, and Gilde Healthcare. Contacts: SynOx Therapeutics Ray Barlow Chief Executive Officer Tel: +44 (0) 208 058 5619 Email: enquiries@synoxtherapeutics.com Vida Strategic Partners (on behalf of SynOx) Tim Brons (Media) 415-675-7402 tbrons@vidasp.com