Delving into the Latest Updates on Beijing Institute of Microbiology & Epidemiology with Synapse

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Introduction

The Institute of Microbiology and Epidemiology was established in 1958 under the Academy of Military Medical Sciences of the Chinese People's Liberation Army (PLA). It consists of six research departments: Bacteriology, Virology, Infection, Immunization and Control, Epidemiology of Infectious Diseases, Analysis of Unknown Pathogens, and Vector Organisms and Biosafety Protection. The institute primarily engages in biomedical protection research to address biological hazards. It has become a leading force in national and military biosafety defense, tasked with scientific research for the nation and the PLA, supporting medical health in major military operations, dealing with stability maintenance and emergency responses, as well as ensuring biosafety during significant events.

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Disease Domain	Count

Infectious Diseases	2

Top 5 Drug Type	Count

Protein drugs	1
Toxin	1
Live attenuated vaccine	1
Prophylactic vaccine	1

Top 5 Target	Count

ZIKV E protein	1

主要目的：健康成年受试者空腹和餐后口服单剂量法匹拉韦片受试制剂与参比制剂后，以药代动力学参数为终点评价指标，评价北京四环制药有限公司生产的法匹拉韦片是否与 Toyama Chemical Co,Ltd 的参比制剂(商品名： AVIGAN®，规格 200mg)具有生物等效性。次要目的：观察受试制剂法匹拉韦片和参比制剂 AVIGAN®在健康受试者中的安全性。

[Translation]

Primary objective: To evaluate whether the Favipiravir Tablets produced by Beijing Sihuan Pharmaceutical Co., Ltd. and the reference preparation (trade name: AVIGAN®, specification 200mg) of Toyama Chemical Co, Ltd. are bioequivalent after oral administration of a single dose of the test preparation and reference preparation of Favipiravir Tablets on an empty stomach and after meals in healthy adult subjects, using pharmacokinetic parameters as endpoint evaluation indicators. Secondary objective: To observe the safety of the test preparation Favipiravir Tablets and the reference preparation AVIGAN® in healthy subjects.

Start Date25 Jun 2020

Sponsor / Collaborator

Beijing Sihuan Pharmaceutical Co. Ltd.

[+1]

ChiCTR1800015894 / RecruitingPhase 4IIT

Clinical efficacy of therapy with T-705 in patients with severe fever with thrombocytopenia syndrome

Start Date17 Apr 2018

Sponsor / Collaborator

Beijing Institute of Microbiology & Epidemiology

100 Clinical Results associated with Beijing Institute of Microbiology & Epidemiology

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0 Patents (Medical) associated with Beijing Institute of Microbiology & Epidemiology

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2,218

Literatures (Medical) associated with Beijing Institute of Microbiology & Epidemiology

31 Dec 2024·Emerging Microbes & Infections

Genomic characters of Anaplasma bovis and genetic diversity in China

Article

Author: Du, Li-Feng ; Wang, Yi-Fei ; Li, Cheng ; Zhu, Wen-Jie ; Zhao, Lin ; Xiong, Tao ; Ye, Run-Ze ; Han, Xiao-Yu ; Wang, Ning ; Cao, Wu-Chun ; Cui, Xiao-Ming ; Lin, Zhe-Tao ; Gao, Wan-Ying

The emergence of Anaplasma bovis or A. bovis-like infection in humans from China and the United States of America has raised concern about the public health importance of this pathogen. Although A. bovis has been detected in a wide range of ticks and mammals in the world, no genome of the pathogen is available up to now, which has prohibited us from better understanding the genetic basis for its pathogenicity. Here we describe an A. bovis genome from metagenomic sequencing of an infected goat in China. Anaplasma bovis had the smallest genome of the genus Anaplasma, and relatively lower GC content. Phylogenetic analysis of single-copy orthologue sequence showed that A. bovis was closely related to A. platys and A. phagocytophilum, but relatively far from intraerythrocytic Anaplasma species. Anaplasma bovis had 116 unique orthogroups and lacked 51 orthogroups in comparison to other Anaplasma species. The virulence factors of A. bovis were significantly less than those of A. phagocytophilum, suggesting less pathogenicity of A. bovis. When tested by specific PCR assays, A. bovis was detected in 23 of 29 goats, with an infection rate up to 79.3% (95% CI: 64.6% ∼94.1%). The phylogenetic analyses based on partial 16S rRNA, gltA and groEL genes indicated that A. bovis had high genetic diversity. The findings of this study lay a foundation for further understanding of the biological characteristics and genetic diversity of A. bovis, and will facilitate the formulation of prevention and control strategies.

31 Dec 2024·Emerging Microbes & Infections

The first reported cases of severe fever with thrombocytopenia syndrome virus from domestic sick camel to humans in China

Article

Author: Ren, Zhenyong ; Liu, Wei ; Liu, Hui ; Sun, Yulan ; Ruan, Chunlai ; Chen, Zhihai ; Wang, Quanyi ; Zhang, Daitao ; Li, Dan ; Du, Zhizhong ; Xue, Hui ; Jin, Haoyuan ; Dou, Xiangfeng ; Ge, Ziruo

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease with an increasing annual incidence rate. In this case report, we presented two patients infected with the SFTS virus, suggesting a potential direct transmission route from camels to humans through blood contact. Both patients developed symptoms after engaging in the slaughtering of one sick camel, while their family members living in the same environment or co-diners remained unaffected. Subsequent detection revealed a high viral load of SFTS virus, reaching 10¹⁰ viral RNA copies/ml, in the sample obtained from the sick camel. Metagenomic sequencing did not identify any other pathogens. The SFTS virus was successfully isolated from both patient and camel samples. The complete nucleotide sequences obtained from the infected patients demonstrated a remarkable 100% similarity to those found in the camel, and genetic evolution analysis classified the virus as genotype A. Additionally, partial sequences of the SFTS virus were identified in ticks captured from the camel rearing environment, however, these sequences showed only 95.9% similarity to those found in camel and humans. Furthermore, immunoglobulin M and immunoglobulin G antibodies were detected in serum samples collected from the patient. Our findings provide evidence that camel may serve as a competent reservoir for transmitting the SFTS virus to humans. Further in vitro investigations into SFTS virus infections in large animals are warranted to understand their role in viral maintenance and transmission.

31 Dec 2024·Virulence

Unraveling host-pathogen dynamics in a murine model of septic peritonitis induced by vancomycin-resistant Enterococcus faecium

Article

Author: Dai, Chenxi ; Zhang, Xi ; Song, Xiaolin ; Zhou, Dongsheng ; Yuan, Xin ; Hu, Lingfei ; Zhang, Jianlong

Vancomycin-resistant Enterococcus faecium (E. faecium) infection is associated with higher mortality rates. Previous studies have emphasized the importance of innate immune cells and signalling pathways in clearing E. faecium, but a comprehensive analysis of host-pathogen interactions is lacking. Here, we investigated the interplay of host and E. faecium in a murine model of septic peritonitis. Following injection with a sublethal dose, we observed significantly increased murine sepsis score and histological score, decreased weight and bacterial burden, neutrophils and macrophages infiltration, and comprehensive activation of cytokine-mediated signalling pathway. In mice receiving a lethal dose, hypothermia significantly improved survival, reduced bacterial burden, cytokines, and CD86 expression of MHC-II⁺ recruited macrophages compared to the normothermia group. A mathematical model constructed by observational data from 80 animals, recapitulated the host-pathogen interplay, and further verified the benefits of hypothermia. These findings indicate that E. faecium triggers a severe activation of cytokine-mediated signalling pathway, and hypothermia can improve outcomes by reducing bacterial burden and inflammation.

100 Deals associated with Beijing Institute of Microbiology & Epidemiology

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100 Translational Medicine associated with Beijing Institute of Microbiology & Epidemiology

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Pipeline

Pipeline Snapshot as of 23 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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