The coronavirus disease 2019 (COVID 19) is a new viral zoonosis of global concern that could cause psychol. sequelae. We examined the levels of psychol. distress, anxiety, depression, and stress during the COVID-19 outbreak in a Mexican sample. An online survey was applied which collected information on demog. and financial status data, phys. status, contact history, knowledge, concerns, and precautionary measures concerning COVID-19. Impact of Event Scale-Revised and Depression, Anxiety and Stress Scale were included. Of the respondents, 50.3% rated psychol. distress as moderate-severe; 15.7% reported moderate-severe depressive symptoms; 22.6% reported moderate-severe anxiety symptoms; and 19.8% reported moderate-severe stress levels. Female gender, older age, divorced status, lack confidence related to security of the test, lower satisfaction of health information concerning COVID-19, history of direct or indirect contact with a COVID-19 confirmed case, live with just one other person and spent >9 h per day at home were associated with greater psychol. distress and(or) higher levels of stress, anxiety, and depression. By contrast, precautionary measures as hand hygiene and wearing masks were associated with lower levels of psychol. distress, depression, anxiety, and stress. Thus, the COVID-19 outbreak results in considerable psychol. effects among the Mexican sample.