Based on the standard big data cloud computing platform of lumbar degenerative diseases, the key technology application of AI intelligent assisted diagnosis and treatment system of TCM external treatment was developed and the individualized TCM external treatment and treatment system was established

Start Date26 Apr 2024

Sponsor / Collaborator

Xinjiang Uygur Autonomous Region Institute of Medicine

CTR20234195

/ RecruitingPhase 2IIT

景红颗粒治疗冠心病心绞痛（气虚血瘀证）的随机、双盲、安慰剂平行对照、剂量探索、多中心、Ⅱa期临床试验景红颗粒Ⅱa期临床试验方案

[Translation] A randomized, double-blind, placebo-controlled, dose-finding, multicenter, phase IIa clinical trial of Jinghong Granules in the treatment of angina pectoris (Qi deficiency and blood stasis syndrome) in coronary heart disease Phase IIa clinical trial plan of Jinghong Granules

以安慰剂为对照，初步探索景红颗粒治疗冠心病心绞痛（气虚血瘀证）的有效性及安全性，并探索最佳剂量。

[Translation]

Using placebo as a control, this study preliminarily explored the effectiveness and safety of Jinghong Granules in treating angina pectoris (Qi deficiency and blood stasis syndrome) due to coronary heart disease, and explored the optimal dose.

Start Date17 Jan 2024

Sponsor / Collaborator

Xinjiang Uygur Autonomous Region Institute of Medicine

ChiCTR2300074972

/ SuspendedEarly Phase 1IIT

A real world study on the construction of a big data diagnosis and treatment platform for lumbar degenerative diseases and the application of intelligent decision system to optimize the diagnosis and treatment plan of TCM external treatment

Start Date01 Oct 2023

Sponsor / Collaborator

Xinjiang Uygur Autonomous Region Institute of Medicine

100 Clinical Results associated with Xinjiang Uygur Autonomous Region Institute of Medicine

0 Patents (Medical) associated with Xinjiang Uygur Autonomous Region Institute of Medicine

Literatures (Medical) associated with Xinjiang Uygur Autonomous Region Institute of Medicine

01 Dec 2025·Natural Products and Bioprospecting

Metabolomic and transcriptomic analyses revealed potential mechanisms of Anchusa italica Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/β-catenin pathway modulation

Article

Author: Zhang, Wen ; Zhang, Li ; Wang, Yufei ; Du, Guanhua ; Song, Junke ; Ding, Guiquan ; Fu, Shuo ; Hu, Bojun ; Tan, Wenta

AbstractAnchusa italica Retz. (AIR), a traditional herbal remedy, is commonly applied in managing heart and brain disorders. However, its specific function and mechanism in acute cerebral ischemia–reperfusion injury (CIRI) are not fully understood. This research focused on the interventional effects and potential mechanisms of AIR extract (AIRE) in a rat model of CIRI. The model was established using the filament occlusion method, which involved blocking the middle cerebral artery for 1.5 h and then removing the filament to restore blood flow. Transcriptomic and metabolomic analyses were conducted to explore the molecular pathways and metabolites affected by AIRE. ATP level was measured using an ATP assay kit. Additionally, RT-qPCR and western blot tests were conducted to evaluate the influence of AIRE on the Wnt signaling pathway and mitochondrial function. Transcriptomic and metabolomic analyses indicated that AIRE regulated the Wnt signaling pathway in CIRI and modulated metabolites associated with mitochondrial energy metabolism, such as citrate and succinate. ATP assay result demonstrated that AIRE enhanced ATP production in CIRI. Further, RT-qPCR and western blot analyses revealed that AIRE activated the Wnt/β-catenin signaling pathway and corrected mitochondrial dysfunction. These results proposed that AIRE mitigated mitochondrial energy metabolism deficits in CIRI via the Wnt/β-catenin pathway. By restoring the balance of mitochondrial function and energy metabolism, AIRE might offer a potentially therapeutic strategy for addressing CIRI.Graphical Abstract

01 Feb 2025·Journal of Ethnopharmacology

Chinese herbal formula Regan Saibisitan alleviates airway inflammation of chronic bronchitis via inhibiting the JAK2/STAT3 pathway

Article

Author: Xing, Jian-Guo ; Ding, Xiao-Rui ; Wang, Shou-Bao ; Xu, Lei ; Su, Wen-Ling ; Kaderyea, Kader ; Zheng, Rui-Fang ; Zeng, Xin ; Han, Yu-Lin ; Wu, Le-He

ETHNOPHARMACOLOGICAL RELEVANCERegan Saibisitan (RGS) is a classic prescription used to treat cough, pneumonia, and other respiratory infections in Uygur medicine. It is a granule composed of 12 kinds of medicinal materials. However, the mechanism by which RGS regulates lung disease remains unclear.AIM OF THE STUDYChronic bronchitis (CB) is characterized by persistent, non-specific inflammation in the trachea, bronchial mucosa, and surrounding tissues mainly resulting from infectious or non-infectious factors. This study aimed to explore the function of RGS in alleviating airway inflammation associated with chronic bronchitis, and to examine the mechanisms by which RGS exerts its effects via the JAK 2/STAT 3 signaling pathway.MATERIALS AND METHODSThe CB mouse model was established by cigarette smoking (CS) and intranasal administration of lipopolysaccharide (LPS, 20 μg), histological changes of bronchial epithelium, collagen deposition, mucus secretion in lung tissue and inflammatory factors were assayed. Transcriptomics analysis was performed to detect the differentially regulated genes in lung tissue of CB mice treated with RGS. The effect of RGS on JAK 2/STAT 3 pathway was investigated in CB mice and NCI-H292 cells treated with PMA using western blotting, ELISA, and immunohistochemical analysis.RESULTSRGS treatment significantly improved the thickening of bronchial epithelium, decreased collagen deposition and secretion of mucus, and the levels of inflammatory factors in CB mice. Transcriptomics analysis showed that most of 402 differentially expressed genes in RGS-treated CB mice were related to inflammatory response. The results in CB mice and NCI-H292 cells showed that RGS reduced the phosphorylation level of JAK 2 and STAT 3. In addition, the use of JAK 2 inhibitor AG490 confirmed that JAK 2/STAT 3 pathway played a key role in the effects of RGS on CB.CONCLUSIONSRGS suppresses inflammation and improves chronic bronchitis in NCI-H292 cells and CB mice, at least in part, via inhibiting the JAK 2/STAT 3 pathway. This study demonstrated that RGS could be a potential drug in treating CB disease.

01 Jan 2025·Biomedicine & Pharmacotherapy

Unlocking the neuroprotective potential of Ziziphora clinopodioides flavonoids in combating neurodegenerative diseases and other brain injuries

Article

Author: Gu, Lili ; Li, Qin ; Wang, Can ; Yang, Weijun ; Du, Qibin ; Zheng, Miao ; Tan, Yilian ; Zhang, Xinyue ; Liu, Jiayi

Ziziphora clinopodioides Lam. (Z. clinopodioides) is a traditional Chinese and ethnic medicine in Xinjiang, China with various therapeutic effects. It is primarily used for conditions such as heart disease, fever with chills, palpitations, and insomnia. Flavonoids are the main medicinal components of Z. clinopodioides, Interestingly, current research has increasingly focused on its neuroprotective effects. This study provides a comprehensive overview of the potential therapeutic applications of Z. clinopodioides and its constituents in central nervous system disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and cerebral ischemia-reperfusion injury. At present, about 25 flavonoids have been isolated and identified from various organs of Z. clinopodioides, including linarin, acacetin, hyperoside, quercetin, apigenin, luteolin, chrysin, kaempferol, baicalein, rutin and others. Modern pharmacological studies have revealed that Z. clinopodioides and its constituents exhibits neuroprotective effects in vitro and in vivo, and the mechanism of action is related to anti-apoptosis, anti-inflammatory, antioxidant, autophagy, endoplasmic reticulum stress and so on. Currently, there is limited research on the extracts of Z. clinopodioides and their potential mechanisms of action in these neurological disorders. It is also important to prioritize research on biosynthetic pathways and chemical modification approaches to fully explore and improve the neuroprotective potential of Z. clinopodioides and its flavonoids and establish a strong foundation for its clinical applications.

100 Deals associated with Xinjiang Uygur Autonomous Region Institute of Medicine

100 Translational Medicine associated with Xinjiang Uygur Autonomous Region Institute of Medicine

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Drug(Targets)	Indications	Global Highest Phase

Kezi Muke Capsule	Pollakisuria More	Phase 2
Kaitong Buzure Granules	Hepatitis A More	Phase 2
Zhike Granules	Cough More	Phase 2
Babuqi Liniment	Vitiligo More	Phase 2
Jinghong Granules	Angina Pectoris More	Phase 2

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