Delving into the Latest Updates on NAEJA-RGM Pharmaceutical, Inc. with Synapse

Overview

Tags

Infectious Diseases

Other Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	4

Top 5 Drug Type	Count

Small molecule drug	4

Top 5 Target	Count

fungal CYP51A1	3
TNF-α(Tumor necrosis factor α)	1

Author: Christopher L. Chio ; Richard Gowan ; David J. Pocalyko ; Fang Sun ; Xiao Dan Ren ; Catherine R. Kostlan ; Neil Raheja ; Ann McCarthy ; Sneha Patel ; Rone Eisma ; Gary F. Filzen ; Leroy Lu ; Feng Bian ; John D. Knafels ; Stephen Fakhoury ; Diane Alessi ; James B. Kramer ; Venkataraman Thanabal ; Paul Angell ; Maria N. Nguyen ; Karen E. Sexton ; Paul R. Keller ; Victoria L. Downs ; Susan M. Ciotti ; Stephen D. Barrett ; N. A. Payne ; Zhi Wang ; Deepak S. Lala ; Huifen Chen ; Richard B. Gilbertsen ; Mostofa A. Hena ; Edmund L. Ellsworth ; Elena M. Drummond ; Erli Zhang ; Patrick McConnell ; Barry C. Finzel ; Larry D. Bratton ; Donna M. Iula ; Samarendra N. Maiti ; Mark L. Boys

A series of 2-(1H-pyrazol-1-yl)pyridines are described as inhibitors of ALK5 (TGFβ receptor I kinase). Modeling compounds in the ALK5 kinase domain enabled some optimization of potency via substitutions on the pyrazole core. One of these compounds PF-03671148 gave a dose dependent reduction in TGFβ induced fibrotic gene expression in human fibroblasts. A similar reduction in fibrotic gene expression was observed when PF-03671148 was applied topically in a rat wound repair model. Thus these compounds have potential utility for the prevention of dermal scarring.

01 Nov 2011·Canadian Journal of Chemistry

Aminomethylation of BINOL with methyleneiminium salts

Author: Shustov, Gennady ; Khlebnikov, Vladimir

A new method for synthesizing chiral 3,3′-bis(N,N-dialkylaminomethyl)-1,1′-bi-2-naphthols with high enantiomeric excess is described. The procedure consists of bis-lithiation of diprotected (S)- or (R)-1,1′-bis(2-naphthol) followed by treatment of the intermediate with methyleneiminium salts. Mild reaction conditions prevent racemization and provide 3,3′-bis(N,N-dialkylaminomethyl)-1,1′-bi-2-naphthols or 3-(N,N-dialkylaminomethyl)-1,1′-bi-2-naphthols with an enantiomeric excess >99%.

01 Dec 2007·Synthesis

Synthesis of Pyrazole, Isoxazole, and Aminopyrimidine Ring-Fused Benzothiocycloheptane-Derived Oxazolidinones and Their Corresponding Sulfone Derivatives

Author: Prasad, J. V. N. Vara ; Boyer, Frederick E. ; Stier, Mike ; Maiti, Samarendra N. ; Khlebnikov, Vladimir

The synthesis of a series of pyrazole, isoxazole, and aminopyrimidine ring-fused benzothiacycloheptane-derived oxazolidinones and their corresponding sulfone derivatives starting from 3-aminobenzeneacetate is described.

100 Deals associated with NAEJA-RGM Pharmaceutical, Inc.

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100 Translational Medicine associated with NAEJA-RGM Pharmaceutical, Inc.

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Pipeline

Pipeline Snapshot as of 19 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

3

Preclinical

Other

8

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

SYN-2921 ( fungal CYP51A1 )	Mycoses More	Preclinical
SYN-2903 ( fungal CYP51A1 )	Mycoses More	Preclinical
SYN-2836 ( fungal CYP51A1 )	Mycoses More	Preclinical
AN-0128 ( TNF-α )	Inflammation More	Discovery
BAL-0019764 ( β-lactamase )	Gram-Positive Bacterial Infections More	Discontinued