Multicolumn chromatog. offers several advantages over conventional batch chromatog., which includes improved productivity, resin and buffer utilization. The presentation describes a quick work flow for evaluation and optimization of multicolumn protein-A capture chromatog. for clin./com. manufacturing process. The protocol was evaluated on three different antibody capture application. 'Multicolumn protein A chromatog. operation' is compared with 'conventional batch protein A chromatog. operation' for 2kL manufacturing scale-up requirements. Addnl., all key performance/quality attribute trend (e.g. yield, elution CV, elution pool pH, HMWP, HCP, HCDNA, LPA content etc.) were monitored during evalaution and compared with batch process. Continuous capture was observed to yield ∼1.9-fold improvement in productivity when compared with batch chromatog.; resulting in 35% to 39% com. media savings and 43% to 48% clin. media savings across three different Mab's. Implementation of ILC along and/or new generation protein A media along with multicolumn protein A chromatog. can further improve the productivity by ∼2-4fold.