This paper reviews our current understanding of how fullerene mols. interact with biol. membranes.First, we discuss how fullerenes permeate into biol. membranes.Next, the putative mechanisms of fullerene aggregation and dispersion within lipid bilayers are discussed along with their potential toxic effect on biol. membranes.Finally, current trends in the study of fullerene-membrane interactions are highlighted as well as future challenges that need to be overcome to further advance the field.