Alume Biosciences, Inc.

LA JOLLA, Calif., Jan. 10, 2023 /PRNewswire/ -- Alume Biosciences, Inc. has secured $13 million in Series B financing to advance its lead candidate, Bevonescein (ALM-488), in Phase 3 clinical trials. Alume, a leader in the field of nerve-targeted diagnostics and therapeutics, announced in August, 2022 that the first patient had been dosed in a Phase 3 pivotal study of ALM-488 for intra-operative visualization of nerves in head and neck surgery (NCT05377554). ALM-488 is a peptide-dye conjugate designed to highlight nerves with fluorescence in real-time during surgery. The Phase 3 pivotal studies are underway at major academic hospitals across the U.S. With the $13 million raised in the Series B fundraising, together with funds raised in an earlier Series A financing and additional non-dilutive funding received through grants, the Company has raised over $30 million to fund the clinical development program for its lead candidate, advance its development portfolio and support potential regulatory filings. ALUME BIOSCIENCES SECURES $13 M IN SERIES B FINANCING "This is an important milestone for Alume. This funding brings us one step closer to improving intraoperative visualization of nerves for patients undergoing surgery, enabling Precision Surgery™" said Magda Marquet, a member of Alume's Board of Directors. About ALM-488 ALM-488 is a proprietary fluorescent peptide-dye conjugate in the visible spectrum and can be visualized with fluorescently enabled instrumentation including filter modified loupe systems, portable handheld systems, microscopes and laparoscopes. ALM-488 binds to the extracellular matrix of nerves, allowing real-time nerve illumination during surgery. ALM-488 is expected to have broad surgical application due to unique characteristics of binding that are independent of myelin, which is an insulating layer around nerves. This allows ALM-488 to highlight multiple types of nerves including motor, sensory, and autonomic. Degenerated nerves, critically important during reconstructive procedures, are also highlighted with ALM-488. Surgeries where nerves are potentially at risk include procedures in the skull base, head and neck, and spine, and nerve sparing prostatectomy. In vivo studies also indicate that ALM-488 has adequate pharmacokinetic characteristics to support clinical utility for the labelling of ureters in urology, gynecology and lower abdominal surgical indications. About Alume Biosciences Alume Biosciences is a late-stage clinical biotechnology company developing nerve specific targeting molecules. In addition to ALM-488, Alume is developing other nerve specific agents for diagnostic and therapeutic indications. The company was founded in 2017 and is headquartered in the Johnson & Johnson Innovation incubator JLABS @ San Diego. Learn more about Alume Biosciences at https://alumebiosciences.com

ALM-488 is a peptide-dye conjugate designed to fluorescently highlight nerves in real time during surgery LA JOLLA, Calif., Aug. 23, 2022 /PRNewswire/ -- Alume Biosciences, Inc, a leader in the field of nerve-targeted diagnostics and therapeutics, today announced that the first patient has been dosed in a Phase 3 pivotal study of ALM-488 (NCT05377554). ALM-488 is a peptide-dye conjugate designed to highlight nerves with fluorescence in real time during surgery. Continue Reading Alume Announces First Patient Dosed in Phase 3 Pivotal Study for Intraoperative Nerve Fluorescence. Tweet this Alume Biosciences Announces First Patient Dosed with ALM-488 in Phase 3 Pivotal Study in Patients Undergoing Head and Neck Surgery. "The successful initiation of this Phase 3 pivotal study is another major milestone for Alume. It marks the final phase of clinical trial testing for ALM-488 for patients undergoing Head and Neck Surgery" said Brett Berman, MD, chief medical officer at Alume Biosciences. "This study underscores our commitment to improve intraoperative visualization of nerves, enabling Precision Surgery™". Alume successfully completed Phase 1/2 studies of ALM-488 in patients undergoing Head and Neck Surgery in 2021. The Phase 3 studies are being conducted at multiple academic medical centers throughout the US, and they are projected to be completed in 2023. "We look forward to exploring the power of ALM-488 as an intraoperative tool to identify nerves and potentially improve outcomes for our patients," said Karthik Rajasekaran MD, principal investigator at University of Pennsylvania. About ALM-488 ALM-488 is a proprietary fluorescent peptide-dye conjugate in the visible spectrum and can be visualized with fluorescently enabled instrumentation including filter modified loupe systems, portable handheld systems, microscopes and laparoscopes. ALM-488 binds to the extracellular matrix of nerves, allowing real-time nerve illumination during surgery. ALM-488 is expected to have broad surgical application due to unique characteristics of binding that are independent of myelin. This allows ALM-488 to highlight multiple types of nerves including motor, sensory, and autonomic. Degenerated nerves, critically important during reconstructive procedures, are also highlighted with ALM-488. Surgeries where nerves are potentially at risk include procedures in the skull base, head and neck, spine, and nerve sparing prostatectomy. In vivo studies also indicate that ALM-488 has adequate pharmacokinetic characteristics to support clinical utility for the labelling of ureters in urology, gynecology and lower abdominal surgical indications. About Alume Biosciences Alume Biosciences is a late-stage clinical biotechnology company developing nerve specific targeting molecules. In addition to ALM-488, Alume is developing other nerve specific agents for diagnostic and therapeutic indications. The company was founded in 2017 and is headquartered in the Johnson & Johnson Innovation incubator JLABS @ San Diego. Learn more about Alume Biosciences at Media contact: [email protected] SOURCE Alume Biosciences

DUBLIN, July 12, 2022 /PRNewswire/ -- The "Global Hospital Care Partnering 2015-2022: Deal Trends, Players and Financials" report has been added to ResearchAndMarkets.com's offering. Global Hospital Care Partnering 2015 to 2022 provides the full collection of Hospital Care disease deals signed between the world's pharmaceutical and biotechnology companies since 2015. Trends in Hospital Care partnering deals Financial deal terms for headline, upfront and royalty by stage of development Hospital Care partnering agreement structure Hospital Care partnering contract documents Top Hospital Care deals by value Most active Hospital Care dealmakers Most of the deals included within the report occur when a licensee obtains a right or an option right to license a licensor's product or technology. More often these days these deals tend to be multi-component including both a collaborative R&D and a commercialization of outcomes element. The report takes readers through the comprehensive Hospital Care disease deal trends, key players and top deal values allowing the understanding of how, why and under what terms companies are currently entering Hospital Care deals. The report presents financial deal terms values for Hospital Care deals, where available listing by overall headline values, upfront payments, milestones and royalties enabling readers to analyse and benchmark the value of current deals. Global Hospital Care Partnering 2015 to 2022 includes: Trends in Hospital Care dealmaking in the biopharma industry since 2015 Access to headline, upfront, milestone and royalty data Access to hundreds of Hospital Care deal contract documents Comprehensive access to over 1200 Hospital Care deal records The leading Hospital Care deals by value since 2015 Most active Hospital Care dealmakers since 2015 Key Topics Covered: Executive Summary Chapter 1 - Introduction Chapter 2 - Trends in Hospital Care dealmaking 2.1. Introduction 2.2. Hospital Care partnering over the years 2.3. Hospital Care partnering by deal type 2.4. Hospital Care partnering by industry sector 2.5. Hospital Care partnering by stage of development 2.6. Hospital Care partnering by technology type 2.7. Hospital Care partnering by therapeutic indication Chapter 3 -Financial deal terms for Hospital Care partnering 3.1. Introduction 3.2. Disclosed financials terms for Hospital Care partnering 3.3. Hospital Care partnering headline values 3.4. Hospital Care deal upfront payments 3.5. Hospital Care deal milestone payments 3.6. Hospital Care royalty rates Chapter 4 - Leading Hospital Care deals and dealmakers 4.1. Introduction 4.2. Most active in Hospital Care partnering 4.3. List of most active dealmakers in Hospital Care 4.4. Top Hospital Care deals by value Chapter 5 - Hospital Care contract document directory 5.1. Introduction 5.2. Hospital Care partnering deals where contract document available Chapter 6 - Hospital Care dealmaking by therapeutic target 6.1. Introduction 6.2. Deals by Hospital Care therapeutic target Companies Mentioned 3D-Side 3D Systems 3M 3SBio 4WEB Medical 7 Hills Pharma 7D Surgical 11 Health and Technologies 111 A&E Medical AAP Implantate AG Aatru Medical Abbvie Abiomed Ab Medica Abram Scientific Absolute Antibody AbSorber Acacia Pharma Acacia Research Acare Medical Science Accelus Accenture Access Scientific Accord Healthcare Accuray AccuTec Blades Acelity Acell Acelrx Pharmaceuticals Acentrus Specialty Acerus ActLight Acuity Healthcare Acuna-Fombona AdaptHealth Adaptimmune ADAS 3D Medical Adeor Medical Adhezion Biomedical ADIENNE Pharma & Biotech Admedus Advanced Aesthetic Technologies Advanced Cooling Therapy Advanced Guidance Technologies Advanced IT Concepts Advanced Ultrasound Systems Advantage Medical Advanz Pharma AdventHealth Aerapy Aerobiotix Aesculap Aesthetic Management Partners Aesthetic Medical International Aethlon Medical Aetna Agadia Systems AgeX Therapeutics Agiliti AgNovos Healthcare Aguettant Aidoc Aiforia Technologies AirStrip Technologies AirXpanders Aitrics Akari Therapeutics Akers Biosciences Akumin ALASTIN Skincare Alfasigma Algeos AliMed AliveCor ALK-Abello Allegheny Technologies Allenex Allergan Allergan Aesthetics Alliance Medical Allied Centre for Medical Excellence Alliqua Biomedical Alloksys Life Sciences AlloSource Almirall Alnylam Pharmaceuticals Alpha Imaging Alphamedix Alphatec Spine Altan Pharma Altaris Capital Partners Altasciences Altitude International Alume Biosciences Alvarado Hospital Medical Center Alyzen Medical Physics Amag Pharmaceuticals Ambra Health Ambu Amedica Amedisys Amendia Amend Surgical American Academy of Orthopaedic Surgeons American College of Chest Physicians American Health Imaging American Medical Technologies American Society for Aesthetic Plastic Surgery American Well Amerinet AmerisourceBergen Amgen AMI Amicrobe AMNIOX Amomed Pharma Amplifire Amplyx Pharmaceuticals Ancestry Anelixis Therapeutics Anelto Angiodynamics Angion Biomedica Angsana Molecular & Diagnostics Anika Therapeutics Anita Tecnica ANP Technologies Antares Pharma Anthem Antibe Therapeutics Apex Physics Partners ApiFix Apollo Endosurgery Appalachian Regional Healthcare Apple Applied DNA Sciences Applimotion APR Medtech Aptevo Therapeutics Archer Capital Arch Therapeutics argenx Argon Medical Devices Aridea Solutions Aridis Pharmaceuticals Arjo Arkansas Childrens Hospital Armaghan Salamat Kish Armis Biopharma Armor Arsenal Medical Artegraft Arteriocyte Medical Systems Arthrex Arthrosurface ARxIUM Asahi Kasei Ascendum Ascension Ascension Saint Thomas Asensus Surgical ASICO AskAt Asklepios Group Aspen Surgical Products Assure Astarte Medical Astellas Pharma AstraZeneca Asys Athersys Atlas Lift Tech ATL Technology Atnahs Pharma Atos Medical Atricure For more information about this report visit Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets