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MechanismM1 receptor antagonists [+1] |
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Drug Highest PhaseApproved |
First Approval Ctry. / Loc.China |
First Approval Date24 Oct 2002 |
/ Not yet recruitingNot ApplicableIIT Effect of Anal Lift Exercise on Rehabilitation After Anal Fistula Surgery: a Single-center, Prospective, Open-label, Randomized Clinical Trial
Anorectal fistula refers to a granulomatous duct located around the rectum and anus. It is mostly caused by infection of the soft tissues surrounding the rectum and anus, and often presents with symptoms such as swelling, pain, and itching around the anus. This causes inconvenience to the patient's daily life. The ideal surgical treatment for anorectal fistula should eliminate sepsis and promote the healing of the duct, while preserving the sphincter and the defecation mechanism. Abbas mentioned the predictive factors for postoperative results of anorectal fistula. Some sinus tracts are relatively deep, the surgical scope is relatively large, the destruction of the rectal ring, which causes a significant feeling of anal distension, will affect the defecation function. After the operation, effective intervention measures should be taken to promote the patient's recovery. Kegel exercise, also known as pelvic floor exercise, is a regular upward lifting and contraction of the anus. It can promote peripheral blood circulation, relieve pain, improve the function of the anal sphincter, and also enhance the strength around the anus to prevent the occurrence of anal incontinence. It is mainly used for the treatment and improvement of anal diseases. When patients perform pelvic floor exercises, they should also pay attention to a light diet and avoid using spicy and irritating foods to avoid affecting the effect of the pelvic floor exercise. Combined with the new pain management concept of this department, for postoperative patients with anorectal fistula, pelvic floor exercise intervention is carried out for constipation and anal heaviness, and the efficacy is observed.
/ Not yet recruitingEarly Phase 1IIT Application of Dynamic Pain Assessment and Management System in Perioperative Period of Patients With Incarcerated Mixed Hemorrhoids: A Single-Center, Prospective, Open-Label, Randomized Controlled Trial
This study aims to investigate whether the dynamic pain assessment and management system can alleviate postoperative pain in patients with incarcerated mixed hemorrhoids and reduce the incidence of complications. A total of 64 eligible patients were enrolled and randomly divided into two groups, with the specific grouping and intervention methods as follows:
① Control Group: Routine drug analgesia and conventional nursing education were adopted.
② Study Group: Patients were managed with the dynamic pain assessment and management system, which included preoperative administration of analgesic drugs, postoperative traditional Chinese medicine (TCM) fumigation, wrist-ankle acupuncture for pain relief, and personalized nursing education.
The study evaluated the effect of the dynamic pain assessment and management system on postoperative analgesia by comparing the Numerical Rating Scale (NRS) scores for pain, recording the Visual Analogue Scale (VAS) scores for quality of life, and analyzing the incidence of complications among patients in different groups. The primary hypothesis of the study is that, compared with routine pain management methods, the dynamic pain assessment and management system can significantly reduce postoperative pain in patients, improve their quality of life, and decrease the incidence of complications (such as bleeding and urinary retention).
/ RecruitingNot ApplicableIIT Application of Wrist-Ankle Acupuncture in Patients With Different Types of Pain Following Perianal Surgery: A Prospective Cohort Study
This study is a prospective clinical observation designed to evaluate the analgesic effect of wrist-ankle acupuncture in patients with different types of pain after perianal surgery, as well as its applicability. A total of 60 eligible postoperative patients were enrolled, with inclusion criteria including age 18-75 years, postoperative Visual Analog Scale (VAS) score ≥4, clear consciousness, and signed informed consent. Exclusion criteria included pregnancy, history of needle fainting, skin lesions at the wrist or ankle, severe systemic diseases, inability to cooperate with follow-up, or participation in other clinical trials. Patients were divided into two groups according to the nature of pain: Group A (sphincter spasm pain, n=30) and Group B (acute incisional pain, n=30). All patients received routine postoperative care (including intravenous flurbiprofen infusion, traditional Chinese medicine soaking, and pain education), and wrist-ankle acupuncture was administered when pain intensity (Verbal Rating Scale, VRS) reached ≥4. The acupuncture method involved superficial subcutaneous insertion in zones 1 and 6 of both lower limbs using disposable sterile needles (0.25 mm × 25 mm). Needles were retained for 0.5-1 hour, once daily, with the treatment course adjusted based on symptom relief. If the VAS score remained ≥4 at 30 minutes post-treatment, adjunctive analgesic medication was administered as prescribed. Observation indicators included postoperative VRS scores, reduction in VAS scores at 5 and 30 minutes after wrist-ankle acupuncture treatment, frequency of analgesic medication use within the first 3 postoperative days, and the Clinical Postoperative Urinary Retention (POUR) score at 24 hours post-surgery. By comparing data between the two groups, the analgesic effect of wrist-ankle acupuncture was analyzed, and the influence of postoperative pain on the occurrence of urinary retention was explored.
100 Clinical Results associated with the Affiliated Hospital of Putian University
0 Patents (Medical) associated with the Affiliated Hospital of Putian University
100 Deals associated with the Affiliated Hospital of Putian University
100 Translational Medicine associated with the Affiliated Hospital of Putian University