Delving into the Latest Updates on Pittsburg State University with Synapse

Overview

Tags

Neoplasms

Infectious Diseases

Urogenital Diseases

Small molecule drug

Chemical drugs

DNA vaccine

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	2
Infectious Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1
DNA vaccine	1
Prophylactic vaccine	1
Chemical drugs	1

Top 5 Target	Count

ADAR1p150	1
SARS-CoV-2 N protein x SARS-CoV-2 S protein	1
AR-v7(androgen receptor splice variant 7)	1

Polyelectrolyte multilayers (PEMs) based on hyaluronic acid (HA) and poly (diallyldimethylammonium chloride) (PDDA) were deposited on oxidized polystyrene (PS_ox) via the layer-by-layer (LbL) method. The X-ray photoelectron spectroscopy (XPS) confirmed the PEM deposition on PS_ox, and atomic force microscopy (AFM) indicated that the surface roughness of PS also increased after PEM deposition. The PEMs significantly enhanced PS wettability, reducing the contact angle from 73° on PS to 24° on PDDA-terminated (PDDA/HA)_2.5 PEM (2.5 bilayers, 5 layers) and 36° on HA-terminated (PDDA/HA)₃ PEM (3 bilayers, 6 layers). The HA-terminated (PDDA/HA)₃ PEM demonstrated antimicrobial activity. Compared to uncoated PS surfaces, this PEM reduced the surface coverage of viable P. aeruginosa cells from 36.5 % to 3.7 % and S. aureus cells from 13.3 % to 2.5 % on uncoated PS surfaces. The antimicrobial assay following the JIS Z 2801-2010 standard demonstrated that the PDDA-terminated (PDDA/HA)_2.5 PEM inhibited S. aureus growth by 48 %, compared to 32 % inhibition by the HA-terminated (PDDA/HA)₃ PEM relative to the uncoated and non-oxidized polystyrene (PS) surface (control). HA-terminated PEM demonstrated lesser antimicrobial activity than PDDA-terminated PEM. However, both PEMs were cytocompatible against erythrocytes and human adipose-derived stem cells (ADSCs), indicating their potential for biomedical applications, particularly prosthetic coatings.

01 Apr 2025·Journal of Polymers and the Environment

Correction to: Structure Development in Cross-Linked, Soybean Oil-based Waterborne Polyurethanes

Author: Hong, Jian ; Ilavsky, Jan ; Vukovic, Milica Lovric ; Djonlagic, Jasna ; Bush, Brian G. ; Petrovic, Zoran S. ; Zhang, Fan

01 Apr 2025·Journal of Alloys and Compounds

Boron nanoengineering: Unveiling breakthroughs and challenges in next-generation lithium batteries

Author: de Souza, Felipe M. ; Gupta, Ram K. ; Pham, Phuong V.

Boron′s electron deficiency results in diverse structural variations and complex electron behavior in its nanostructures.Since graphene′s discovery, interest in boron-based nanoengineering has grown, with studies exploring its unique structural, elec., and electrochem. properties, especially for batteries.However, boron nanostructures face significant challenges, particularly poor stability, which limits their application in energy storage.To overcome this, research focuses on improving boron′s redox reaction kinetics, alk. cation adsorption, and overall stability as an electrode material.Despite progress, major knowledge gaps remain, highlighting the need for further theor. and exptl. studies.Boron-based batteries offer both opportunities and challenges, requiring systematic investigation into the fabrication, properties, and applications of boron materials.This review covers the main aspects of B within the field of energy storage applications since the synthesis of B-based nanomaterials and its uses as electroactive materials in batteries such as Li-ion, Li-S as well as electrolytes.In addition, some of the latest studies are discussed as a means to elucidate the intricacies of B nanoengineering and the ways that it can benchmark the performance of different types of batteries.In this sense, some of the key strategies include B-doping in nanocarbons, surface functionalization, heterostructure interface engineering with borophene, and the development of 3D porous borophene architectures to enhance stability and electrochem. performance in Li-ion and Li-S batteries.Addnl., the review discusses challenges related to manufacturing, scalability, stability, characterization, and safety.Lastly, the authors emphasize borophene′s potential to drive advancements in 2D materials and battery research, aiming to inspire innovative approaches for future development.

100 Deals associated with Pittsburg State University

Login to view more data

100 Translational Medicine associated with Pittsburg State University

Login to view more data

Corporation Tree

Boost your research with our corporation tree data.

login

or

view full example data

Boost your research with our corporation tree data.

Pipeline

Pipeline Snapshot as of 11 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

3

2

Other

Login to view more data

Current Projects

Drug(Targets)	Indications	Global Highest Phase

CL-AD-100 ( ADAR1p150 )	Neoplasms More	Preclinical
Ad5.SARS-CoV-2-S1N ( SARS-CoV-2 N protein x SARS-CoV-2 S protein )	Coronavirus Infections More	Preclinical
CL-AR-200 ( AR-v7 )	Castration-Resistant Prostatic Cancer More	Preclinical
Cancer vaccine MUC-1(GSK)	Neoplasms More	Discontinued
Ad5.SARS-CoV-2-S1 ( SARS-CoV-2 S protein )	Coronavirus Infections More	Pending