Delving into the Latest Updates on Jiangsu Jiarui Biotechnology Co., Ltd. with Synapse

Overview

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Neoplasms

Chemical drugs

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Chemical drugs	1

一、剂量递增（第1部分）主要目的：评价JR8603 的安全性和耐受性；确定最大耐受剂量(MTD)和/II 期推荐剂量（ RP2D ）。次要目的：确定JR8603 在晚期实体瘤中的有效性；评估JR8603 的药代动力学（PK）特征。探索性目的：通过血清和肿瘤组织中生物标志物的表达以及血清Legumain 水平评估ORR。二、剂量扩展（第2部分）主要目的：确定MTD/RP2D 下JR8603 的安全性和耐受性；评估各队列有效性的初步证据。次要目的：进一步评估JR8603 的PK 特征；确定JR8603 在各队列的有效性。探索性目的：通过血清和肿瘤组织中生物标志物的表达以及血清Legumain 水平评估ORR。

[Translation]

I. Dose escalation (Part 1) Primary objectives: Evaluate the safety and tolerability of JR8603; determine the maximum tolerated dose (MTD) and/phase II recommended dose (RP2D). Secondary objectives: Determine the efficacy of JR8603 in advanced solid tumors; evaluate the pharmacokinetic (PK) characteristics of JR8603. Exploratory objectives: Evaluate ORR by the expression of biomarkers in serum and tumor tissues and serum Legumain levels. II. Dose expansion (Part 2) Primary objectives: Determine the safety and tolerability of JR8603 under MTD/RP2D; evaluate the preliminary evidence of efficacy in each cohort. Secondary objectives: Further evaluate the PK characteristics of JR8603; determine the efficacy of JR8603 in each cohort. Exploratory objectives: Evaluate ORR by the expression of biomarkers in serum and tumor tissues and serum Legumain levels.

Start Date-

Sponsor / Collaborator

Jiangsu Jiarui Biotechnology Co., Ltd.

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100 Clinical Results associated with Jiangsu Jiarui Biotechnology Co., Ltd.

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0 Patents (Medical) associated with Jiangsu Jiarui Biotechnology Co., Ltd.

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100 Deals associated with Jiangsu Jiarui Biotechnology Co., Ltd.

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100 Translational Medicine associated with Jiangsu Jiarui Biotechnology Co., Ltd.

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Pipeline

Pipeline Snapshot as of 23 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

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