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Prophylactic vaccine	2

Methylnissolin-3-O-β-d-glucopyranoside (MNG) and methylnissolin (MN) are pterocarpan derivatives that are found in plants, such as Astragalus membranaceus. There are limited existing studies on the potential health benefits of MNG, and currently there is no evidence to suggest that MNG has any impact on skin-aging. Tumor necrosis factor-alpha (TNF-α) plays a significant role in skin aging by promoting chronic inflammation, damaging skin cells, and impairing the skin's natural repair mechanisms. Targeting TNF-α or its downstream signaling pathways may be a promising strategy for preventing or reversing skin-aging. We tested the effect of MNG and MN on skin-aging by inducing cell inflammation and oxidative stress with TNF-α in HDFs. MNG and MN significantly reduced the TNF-α-induced secretion of matrix metalloproteinase-1 (MMP-1). However, MNG has more beneficial compound for oral administration than MN in pharmacokinetics analysis. The mechanism underlying the anti-skin-aging effect of MNG is related to the suppression of TNF-α-induced reactive oxygen species (ROS) generation and mitogen-activated protein kinase (MAPKs) phosphorylation. Our results suggest that MNG is a potential candidate for preventing skin-aging induced by TNF-α.

01 Jan 2025·The Physics Teacher

Autumn Foliage and the Photoelectric Effect

Author: Binder, P.-M.

31 Dec 2024·Innovation in Aging

AGE AND GENDER IMPACTS ENDORSEMENT OF NOSTALGIA ACROSS SEVEN YEARS

Author: Wildschut, Tim ; Turner, Jennifer ; Sedikides, Constantine

AbstractThe experience of nostalgia (a bittersweet longing for one’s past) is common amongst people of all ages (Hepper et al., 2021; Juhl et al., 2020). Recent work described age-group differences in the frequency of nostalgia, such that older adults reported more nostalgia compared to middle-aged and younger adults (Turner & Stanley, 2021). Some have posited that age-related differences in nostalgia are founded on changing emotion-regulation goals and future time perspective in later life (Hepper et al., 2021), yet one problem has been the emphasis on cross-sectional studies which limit understanding of potential developmental change in nostalgia. This study extends previous work by examining the relevance of individual differences (i.e., age and gender) for endorsement of nostalgia in a nationally-representative sample of Dutch-speaking participants (N=2,664, 53.5% women) using a longitudinal design from the LISS panel (8-waves collected 2012-2019). At baseline, participants’ ages ranged between 9-93 years (M=48.59, SD=18.07). At each wave, participants completed the 7-item Southampton Nostalgia Scale (Sedikides et al., 2015), which assesses how frequently, and how much, one values the experience of nostalgia (Wang et al., 2023). As expected, analyses supported both between-person age differences, with older adults endorsing greater nostalgia than younger ones, and within-person age-related increases in nostalgia. Gender differences also emerged, such that women were more nostalgic than men on average, but this was qualified by a significant interaction with age: men (but not women) demonstrated increases in nostalgia with age. Results are interpreted through the lens of Socioemotional Selectivity Theory (Carstensen, 2021).

100 Deals associated with University of Hawai'i at Hilo

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100 Translational Medicine associated with University of Hawai'i at Hilo

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Pipeline

Pipeline Snapshot as of 31 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Bivalent Thermostabilized Filovirus Vaccine(Soligenix)	Marburg Virus Disease More	Preclinical
Ebola virus vaccine(Hawaii Biotech)	Hemorrhagic Fever, Ebola More	Preclinical