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Overview

Heart failure (HF) is a severe cardiovascular disease with extremely high morbidity and mortality rates worldwide, and ischemic cardiomyopathy is an important cause of heart failure. Vericiguat is a soluble guanylate cyclase stimulator which has been verified to improve the cardiovascular outcomes in heart failure patients. The VICTORIA trial excluded patients with acute coronary syndrome in 3 months prior to the study start, so it is still unclear about the efficacy and safety of vericiguat in heart failure after acute myocardial infarction. So we conducted this multi-center, prospective, cohort study to estimate the efficacy and safety of vericiguat in HF patients after acute myocardial infarction.

Start Date01 Apr 2025

Sponsor / Collaborator

Chongqing Emergency Medical Center

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ChiCTR2400094117

/ SuspendedNot Applicable

Oliceridine for postoperative analgesia in adults with lower limb fractures: a randomized, controlled, double-blind clinical study

Start Date01 Jan 2025

Sponsor / Collaborator

Chongqing Emergency Medical Center

ChiCTR2400092334

/ RecruitingNot Applicable

A multicenter study of the prognosis of diabetes mellitus in the context of prehospital emergency

Start Date15 Nov 2024

Sponsor / Collaborator

Chongqing Emergency Medical Center

100 Clinical Results associated with Chongqing Emergency Medical Center

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0 Patents (Medical) associated with Chongqing Emergency Medical Center

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62

Literatures (Medical) associated with Chongqing Emergency Medical Center

01 May 2025·International Journal of Biological Macromolecules

Role of bFGF on astrocytes to expression of protein molecules of blood-brain barrier via PI3K/mTOR signaling pathway after TBI

Article

Author: Wang, Yanglingxi ; Long, Haibo ; Chen, Peng ; Deng, Yongbing ; Zhou, Weiduo ; Xiong, Weiming ; Zhang, Ying ; Chen, Feng

Traumatic brain injury (TBI) can lead to a breakdown of the blood-brain barrier (BBB), which can exacerbate brain damage. Basic fibroblast growth factor (bFGF) has a neuroprotective effect, but its effect on BBB integrity after TBI and its underlying mechanism remain unclear. To investigate the changes of BBB-related protein expression in TBI model rat astrocytes under bFGF intervention, and the regulatory role of PI3K/mTOR signaling pathway in this process. The study used animal models to simulate TBI and administered different doses of bFGF intervention. The integrity of BBB was assessed by measuring cerebral water content (BWC) and histological observation. Western blot results showed that bFGF treatment up-regulated BBB-related protein expression in astrocytes and activated PI3K/mTOR signaling pathway. bFGF promotes the expression of BBB-related protein molecules in astrocytes after TBI by activating PI3K/mTOR signaling pathway, thereby improving the integrity of BBB and playing a neuroprotective role.

23 Apr 2025·Open Medicine

Semaglutide treatment for type 2 diabetes in a patient with chronic myeloid leukemia: A case report and review of the literature

Author: Zhang, Yuchen ; Li, Anxin

AbstractBackgroundComorbid type 2 diabetes mellitus (T2DM), severe obesity, and chronic myeloid leukemia (CML) present therapeutic challenges, especially given the limited data on glucagon-like peptide-1 (GLP-1) receptor agonists in this setting.MethodsWe describe a 33-year-old female with poorly controlled T2DM (HbA1c 10.7%), severe obesity (BMI 47.05 kg/m2), and stable CML on tyrosine kinase inhibitor therapy. She received once-weekly semaglutide (0.5–1.5 mg) for 6 months, alongside insulin glargine and dapagliflozin/metformin. Clinical, biochemical, and molecular parameters were monitored.ResultsAfter 6 months, her HbA1c declined from 10.7 to 5.5%, fasting plasma glucose from 16.2 to 5.3 mmol/L, and body weight decreased by 18 kg. Lipid parameters improved, and molecular analysis confirmed continued CML remission (undetectable BCR-ABL1). The patient experienced only mild, transient gastrointestinal side effects.ConclusionIn this complex case, semaglutide proved safe and effective for achieving glycemic control and weight reduction without compromising CML stability. These findings suggest that GLP-1 receptor agonists may be a viable therapeutic option for patients with coexisting T2DM, severe obesity, and stable CML, warranting further investigation in broader populations.

01 Apr 2025·Urology

Reply to Editorial Comment on “Efficacy and Safety of Ultrasound- vs Fluoroscopy-Guided Percutaneous Nephrolithotomy in Managing Renal Calculi: A Systematic Review and Meta-Analysis of Randomized Controlled Trials”

Article

Author: Yi, Tong ; Du, Ruoyang ; Feng, Wubing

100 Deals associated with Chongqing Emergency Medical Center

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100 Translational Medicine associated with Chongqing Emergency Medical Center

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