3'-Substituted propanolursolates were obtained by a reaction of ursolic acid with trimethylene bromide.This intermediate reacted with several N-containing compounds to afford a series of new derivativesThe structures of new products were characterized by means of 1H NMR, 13C NMR, IR and MS techniques.The preliminary bioassay test shows that several compounds give a good antitumor activity, and most of them are better than that of parent ursolic acid.Among them, compound I shows the best activity.