Delving into the Latest Updates on Tarbiat Modares University with Synapse

Overview

Tags

Skin and Musculoskeletal Diseases

Neoplasms

Eye Diseases

Radiolabeled antibody

Therapeutic radiopharmaceuticals

Synthetic peptide

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	2

Top 5 Drug Type	Count

Synthetic peptide	1
Monoclonal antibody	1
Therapeutic radiopharmaceuticals	1
Radiolabeled antibody	1

Top 5 Target	Count

MUC1(Mucin-1)	2
MMP9(Matrix metalloproteinase 9)	1

The production of hydrogen gas as an environmentally friendly and emission-free fuel source, has emerged as the preeminent substitute for traditional fossil fuels. The demand for a viable and low-cost substitute of the anodic Oxygen Evolution Reaction (OER) in hydrogen gas production has led researchers to explore the Hydrazine Oxidation Reaction (HzOR), aiming to reduce overpotential. In this study, we present the synthesis of a NiSeP@NiCo/Cu electrocatalyst via electrodeposition method, offering precise control over parameter adjustments and an affordable price. The binder-free nanosheet structure of this electrocatalyst demonstrates improved performance in water electrolysis, resulting in potentials of -40 and -134 mV vs. Reversible Hydrogen Electrode (RHE) for Hydrogen Evolution Reaction (HER) and 0.041 and 0.194 V (vs. RHE) for HzOR (i = 10 and 100 mA.cm^-2). The electrode has excellent features, including active electrochemical surface, synergistic effects among the elements, high stability, super-hydrophilicity and super-aerophobicity. The Bi-functional performance of electrode was tested in a two-electrode set for HER/HzOR, the cell voltage required to reach current densities of 10 and 100 mA.cm^-2 were determined as 0.071 and 0.298 V respectively. On the whole, this work presents the excellent capabilities of the synthesized electrode (NiSeP@NiCo/Cu) for hydrogen gas production.

01 Jan 2025·Journal of the European Ceramic Society

Microstructure, electrical and magnetic properties of MgFe2O4 sintered with (1-x)Bi2O3.xFe2O3 additives

Author: Poursalehi, Reza ; Yourdkhani, Amin ; Abbasi, Kiana

In this research, liquid phase sintering of MgFe₂O₄ with a Bi₂O₃-Fe₂O₃ additive was studied.Initially, MgFe₂O₄ powder was synthesized at 1150 °C, then 3 wt% additive with (1-x)Bi₂O₃.xFe₂O₃ (x=0.00, 0.04, 0.08, 0.12) was added to the powder and sintered at 1050 °C.The x=0.04 sample showed the highest d. of ∼4.40 g/cm³.Cubic spinel ferrite and phases containing bismuth oxide were formed in all samples, notably, only x=0.08 and x=0.12 samples consist hematite.Uniform microstructure was achieved for x=0.00 and 0.04 samples while other samples exhibited non-uniform porous microstructures.EDS anal. revealed uniform iron distribution in the grains of x=0.04 sample, unlike the x=0.00 sample.Impedance spectroscopy indicated increased elec. resistivity in x=0.04 compared to x=0.00.Saturation magnetization peaked at 18.5 emu/g for x=0.04, then decreased, while coercive force rose from 13.2 to 30.2 Oe with increasing x.The x=0.04 additive acted as the optimal sintering aid, improving elec. and magnetic properties.

01 Jan 2025·Bioactive Materials

Advancements in hydrogel design for articular cartilage regeneration: A comprehensive review

Review

Author: Seitz, Hermann ; Collins, Maurice N. ; Hashemi-Afzal, Fariba ; Collins, Maurice N ; Bagheri, Fatemeh ; Eslaminejad, Mohamadreza Baghaban ; Fallahi, Hooman

This review paper explores the cutting-edge advancements in hydrogel design for articular cartilage regeneration (CR). Articular cartilage (AC) defects are a common occurrence worldwide that can lead to joint breakdown at a later stage of the disease, necessitating immediate intervention to prevent progressive degeneration of cartilage. Decades of research into the biomedical applications of hydrogels have revealed their tremendous potential, particularly in soft tissue engineering, including CR. Hydrogels are highly tunable and can be designed to meet the key criteria needed for a template in CR. This paper aims to identify those criteria, including the hydrogel components, mechanical properties, biodegradability, structural design, and integration capability with the adjacent native tissue and delves into the benefits that CR can obtain through appropriate design. Stratified-structural hydrogels that emulate the native cartilage structure, as well as the impact of environmental stimuli on the regeneration outcome, have also been discussed. By examining recent advances and emerging techniques, this paper offers valuable insights into developing effective hydrogel-based therapies for AC repair.

100 Deals associated with Tarbiat Modares University

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100 Translational Medicine associated with Tarbiat Modares University

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Pipeline

Pipeline Snapshot as of 23 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

3

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