The goal of this [Efficacy of a traditional anti-diabetic herbal drug with on glycemic, inflammatory, and oxidative stress parameters] is [investigate the level of HOMA-estimated insulin resistance as the primary outcome before and after 40 days in intervention and placebo groups] in [patients with type 2 diabetes]. The secondary outcomes of this study are the assessment of oxidative stress, inflammation biomarkers, other glycemic indices, hematopoietic status and lipid profile between the two groups before and after the intervention. also The food frequency questionnaire (FFQ) and the physical activity questionnaire (FAQ) are used to evaluate the effect of potential confounding factors. This study has the code of ethics IR.KMU.REC.1402.291 from Kerman University of Medical Sciences and this drug has the number 12/14484 from Iran Food and Drug Administration (IFDA).

Start Date14 Mar 2025

Sponsor / Collaborator

Kerman Medical University

IRCT20240905062953N1 / SuspendedPhase 2/3IIT

Investigating the effectiveness of pramipexole on anhedonia in patients undergoing maintenance therapy by buprenorphine: randomized double blind placebo: controlled trial

Start Date05 Nov 2024

Sponsor / Collaborator

Kerman Medical University

IRCT20240316061302N1 / SuspendedPhase 2/3IIT

Investigation of vitamin C and vitamin E co-treatment in improvement of clinical and paraclinical findings of lung contusion patients

Start Date22 Oct 2024

Sponsor / Collaborator

Kerman Medical University

100 Clinical Results associated with Kerman Medical University

0 Patents (Medical) associated with Kerman Medical University

7,921

Literatures (Medical) associated with Kerman Medical University

01 Dec 2024·Molecular Biology Reports

Combinatorial targeting of telomerase and DNA-PK induces synergistic apoptotic effects against Pre-B acute lymphoblastic leukemia cells

Article

Author: Ashoub, Muhammad Hossein ; Katoueezadeh, Maryam ; Maleki, Parisa ; Nurain, Ismaila Olanrewaju ; Valandani, Hajar Mardani ; Torabizadeh, Seyedeh Atekeh ; Farsinejad, Alireza ; Fatemi, Ahmad ; Khalilabadi, Roohollah Mirzaee

BACKGROUNDDue to the high demand for novel approaches for leukemia-targeted therapy, this study investigates the impact of DNA-PK inhibitor NU7441 on the sensitivity of pre-B ALL cells to the telomerase inhibitor MST-312.METHODSThe study involved NALM-6 cells treated with MST-312 and NU7441, assessing their viability and metabolic activity using trypan blue and MTT assays. The study also evaluated apoptosis, gene expression changes, and DNA damage using flow cytometry, qRT-PCR, and micronucleus assays. The binding energy of MST-312 in the active site of telomerase was calculated using molecular docking.RESULTSThe study's findings revealed a synergistic decline in both cell viability and metabolic activity in NALM-6 cells when exposed to the combined treatment of MST-312 and NU7441, and this decrease occurred without any adverse effects on healthy PBMC cells. Furthermore, the combination treatment exhibited a significantly higher induction of apoptosis than treatment with MST-312 alone, as observed through flow cytometry assay. qRT-PCR analysis revealed that this enhanced apoptosis was associated with a notable downregulation of Bcl-2 expression and an upregulation of Bax gene expression. Moreover, the combination therapy decreased expression levels of hTERT and c-Myc genes. The micronucleus assay indicated that the combination treatment increased DNA damage in NALM-6 cells. Also, a good conformation between MST-312 and the active site of telomerase was revealed by docking data.CONCLUSIONSThe study suggests that simultaneous inhibition of telomerase and DNA-PK in pre-B ALL presents a novel targeted therapy approach.

01 Dec 2024·Molecular Biology Reports

Interaction of estradiol and renin–angiotensin system with microRNAs-21 and -29 in renal fibrosis: focus on TGF-β/smad signaling pathway

Review

Author: Kazeminia, Sara ; Saberi, Shadan ; Rajizadeh, Mohammad Amin ; Shahraki, Sarieh ; Rajabi, Soodeh ; Askaripour, Majid ; Najafipour, Hamid

Kidney fibrosis is one of the complications of chronic kidney disease (CKD (and contributes to end-stage renal disease which requires dialysis and kidney transplantation. Several signaling pathways such as renin-angiotensin system (RAS), microRNAs (miRNAs) and transforming growth factor-β1 (TGF-β1)/Smad have a prominent role in pathophysiology and progression of renal fibrosis. Activation of classical RAS, the elevation of angiotensin II (Ang II) production and overexpression of AT1R, develop renal fibrosis via TGF-β/Smad pathway. While the non-classical RAS arm, Ang 1-7/AT2R, MasR reveals an anti-fibrotic effect via antagonizing Ang II. This review focused on studies illustrating the interaction of RAS with sexual female hormone estradiol and miRNAs in the progression of renal fibrosis with more emphasis on the TGF-β signaling pathway. MiRNAs, especially miRNA-21 and miRNA-29 showed regulatory effects in renal fibrosis. Also, 17β-estradiol (E2) is a renoprotective hormone that improved renal fibrosis. Beneficial effects of ACE inhibitors and ARBs are reported in the prevention of renal fibrosis in patients. Future studies are also merited to delineate the new therapy strategies such as miRNAs targeting, combination therapy of E2 or HRT, ACEis, and ARBs with miRNAs mimics and antagomirs in CKD to provide a new therapeutic approach for kidney patients.

01 Dec 2024·Letters in Drug Design & Discovery

Bioactivity-guided Separation of Antinociceptive and Antioxidant Subfractions from Alkaline Chloroform Fraction of Fenugreek Seeds (Trigonella foenum-graecum L.) in an Animal Model

Author: Abbasi, Mahboobe ; Mohamadi, Neda ; Mandegary, Ali ; Pournamdari, Mostafa ; Sharififar, Fariba ; Asadi, Amir

Background:Antinociceptive effect of fenugreek seeds (Trigonella foenum-graecum L.) has been reported in different animal models in response to various chemical or thermal stimuli. In a recent study, alkaline chloroform fraction (AKC) of this plant has exhibited the greatest analgesic effect.Objective:In the present study, to isolate the active component(s) from the plant, the subfractions resulting from AKC column chromatography were evaluated in an animal model for anti-nociception effect.Methods:From the 17 separated fractions, 5 major fractions (F4, F6, F14, F15 and F16) were used for the formalin test at three different doses (2.5, 5 10 mg/kg). Antioxidant activity of the most active subfractions was studied too.Results:Subsections F16 and F14 (5, 10 mg/kg) showed the greatest analgesic effect and reduced, which was similar to morphine and even stronger than morphine in some doses. The greatest antioxidant activity was observed by F14 (radical inhibition percentage of 17.34± 0.14 in DPPH assay, reduction power percentage of 74.05±4.23 in RPA versus green tea (91.68± 3.04 and 97.59± 6.24 in DPPH assay and RPA test respectively). The absorbance of F14 was 0.25±0.11 in the FTC method in comparison to ascorbic acid 10 μg/ml and 100 μg/ml (0.72±0.33 and 0.05±0.41 respectively).Conclusion:Separated subfractions exhibited more antinociceptive effect than AKC fraction, so further separation can lead to the acquisition of antinociceptive compound (s), while AKC fraction was found to be more potent antioxidant than separated sub-fractions in all three experiments. So, most likely, the anti-nociception effect of subfractions might be achieved via other mechanisms than antioxidant activity. Based on phytochemical screening, AKC and all sub-fractions especially F14, F15 and F16 were positive for the presence of alkaloids and only F14 was positive for flavonoids.

100 Deals associated with Kerman Medical University

100 Translational Medicine associated with Kerman Medical University

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