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Last update 08 May 2025

Shanghai Pudong New Area People's Hospital

Hospital|Shanghai Shi, China

Last update 08 May 2025

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Translational Medicine

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Clinical Trials associated with Shanghai Pudong New Area People's Hospital

NCT06943729

/ Not yet recruitingNot ApplicableIIT

Clinical Safety and Efficacy of Flow Diverter in the Treatment of Intracranial Aneurysms

To collect the safety and effectiveness data of flow-di in the treatment of intracranial aneurysms in real-world clinical practice, verify its classification of treatment strategies for aneurysms of different locations and shapes, and optimize postoperative medication regimen, provide long-term evidence-based basis for clinical treatment of intracranial aneurysms, and build a database.

Start Date30 Apr 2025

Sponsor / Collaborator

Shanghai Huashan Hospital

[+16]

ChiCTR2400091366

/ RecruitingNot ApplicableIIT

Research on the construction and application of discharge preparation plan for patients with type 2 diabetes based on Meleis transition theory

Start Date28 Oct 2024

Sponsor / Collaborator

Shanghai Pudong New Area People's Hospital

ChiCTR2400090519

/ RecruitingNot ApplicableIIT

Current status and correlation analysis of diabetic patients’ health-related behavioral protective motivations and disease benefit perception

Start Date08 Oct 2024

Sponsor / Collaborator

Shanghai Pudong New Area People's Hospital

100 Clinical Results associated with Shanghai Pudong New Area People's Hospital

0 Patents (Medical) associated with Shanghai Pudong New Area People's Hospital

509

Literatures (Medical) associated with Shanghai Pudong New Area People's Hospital

31 Dec 2025·Pharmaceutical Biology

Yiqi Wenyang decoction protects against the development of atherosclerosis by inhibiting vascular inflammation

Article

Author: Jiang, Weimin ; Yan, Xingqun ; Gu, Ping ; Sun, Lingling ; Zhu, Yao ; Shiu, Chiwen ; Zhang, Han ; Hua, Shuang ; Huang, Zhe ; Zhang, Shujie

CONTEXTVascular inflammation is a key process in the pathogenesis of atherosclerosis, which is regulated by NF-κB pathway. Yiqi Wenyang decoction (YQWY), a Traditional Chinese medicine (TCM) formula, has anti-inflammatory properties and may inhibit this pathway, potentially offering anti-atherosclerotic effects.OBJECTIVEThe purpose of this study is to investigate the effects of YQWY on atherosclerosis and the underlying mechanism. Materials and methods: ApoE^-/- mice were fed a Western diet and administered with YQWY (low or high dose), atorvastatin, or vehicle for 13 weeks. The size of atherosclerotic plaques was assessed using ORO staining. Vascular inflammation was evaluated with IF or IHC staining. The mechanisms and signaling pathways underlying the effect of YQWY on vasculature were studied using transcriptomic analysis and were validated in vitro in endothelial cells and macrophages.RESULTSYQWY attenuated atherosclerotic plaque development which was associated with reduced vascular inflammation as demonstrated by transcriptomic analysis of aorta. This was verified by reduced expression of proinflammatory chemokines, adhesion molecules, and inflammatory cytokines in aortas from YQWY-treated mice at both mRNA and protein levels. Mechanistically, YQWY suppressed NF-κB activation in endothelial cells and, to a lesser extent, macrophages possibly.DISCUSSION AND CONCLUSIONSYQWY protects against vascular inflammation and atherosclerosis by suppressing NF-κB pathway, suggesting the potential of YQWY and its active ingredients as novel anti-atherosclerotic therapeutics.

31 Dec 2025·Renal Failure

The atherogenic index of plasma increases the risk of incident kidney stones: a nested case–control study in Chinese adults

Article

Author: Zhu, Yu ; Wang, Jun ; Wang, Hui ; Shi, Feng ; Wang, Dawei ; Zhang, Dingguo

OBJECTIVETo investigate the association between atherogenic index of plasma (AIP) and risk of incident kidney stones.METHODSA nested case-control study was conducted using data from the Shanghai Kidney Stone Cohort from December 2018 to February 2023. Kidney stones were ascertained by ultrasound. Propensity score matching selected 2,550 patients with incident kidney stones and 5,100 controls from a total of 64,121 adults. Baseline fasting plasma samples were collected to measure the AIP, defined as the logarithm of the ratio triglycerides to high-density lipoprotein cholesterol. A multivariable conditional logistic regression model and restricted cubic spline were applied to examine the association between the AIP and the risk of incident kidney stones.RESULTSThe baseline AIP values of the incident kidney stone patients and controls were 0.98 (0.67) and 0.91 (0.65), respectively. Patients with incident kidney stones had much higher baseline AIP levels than controls (p < 0.001). Participants in the highest AIP quartile had a 29% greater risk of developing kidney stones. Moreover, each increase in the standard deviation of the AIP was associated with a 10% greater risk of nephrolithiasis. A restricted cubic spline showed a significant positive and linear correlation between the AIP and the risk of developing kidney stones (P-overall = 0.040, P-nonlinear = 0.923). These findings remained robust in sensitivity analyses.CONCLUSIONSA higher AIP is associated with a greater risk of incident kidney stones.

01 Jul 2025·Bioactive Materials

Noninvasive method for achieving the regeneration of damaged nerves via ultrasonic nasal drops

Article

Author: Wang, Fan ; Han, Zeyu ; Ruan, Huitong ; Wong, Duo Wai-Chi ; Qiu, Yan ; Chen, Yanyang ; Shen, Gracie ; Cui, Wenguo ; Zhu, Ning ; Liu, Mingyue ; Ni, Ming ; Ling, Shifeng ; Ye, Shenglin

Repair and regeneration of damaged neurons is a promising therapeutic strategy for central nervous system (CNS) diseases such as ischemic stroke (IS). However, achieving efficient neuronal repair and regeneration after CNS injury through noninvasive methods remains a significant challenge. Therefore, this study proposes, for the first time, an ultrasonic nasal drop formulation that induces efficient regeneration of damaged neurons through electropharmacological coupling in an noninvasive manner. Liposomes containing the natural anti-inflammatory drug Timosaponin B-II (TB) were coated onto barium titanate nanoparticles (BTO) to form LTO@TB. Using microfluidic technology and a Schiff base reaction, LTO@TB was encapsulated into aldehyde-based and methacrylate-modified microspheres (MS) to create the ultrasonic nasal drop MS@LTO@TB. The aldehyde groups of MS@LTO@TB spontaneously formed amide bonds with the numerous amino groups in the nasal mucosa, facilitating specific adhesion. Due to its enhanced bioadhesion and efficient transmembrane transport, LTO@TB was continuously and noninvasively delivered to the brain when administered nasally. Additionally, under ultrasonic stimulation, LTO@TB in the brain exerted an electropharmacological coupling effect, achieving noninvasive electrical stimulation of damaged neurons. MS@LTO@TB modulated microglial phenotypes, restored electrical signal conduction among damaged neurons, reshaped the inflammatory microenvironment, reduced neuronal apoptosis, activated the PI3K/AKT signaling pathway, and promoted axonal regeneration. MS@LTO@TB also showed the unique ability to alleviate inflammation and promote neuronal remodeling in a mouse model of middle cerebral artery occlusion/reperfusion (MCAO/R). This study presents a promising strategy involving the nasal administration of ultrasonic nasal drops as a noninvasive and efficient treatment for CNS injuries.

100 Deals associated with Shanghai Pudong New Area People's Hospital

100 Translational Medicine associated with Shanghai Pudong New Area People's Hospital

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