Delving into the Latest Updates on NeoRegen Biotech Co.,Ltd with Synapse

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Congenital Disorders

Neoplasms

Other Diseases

Antibody

Small molecule drug

Synthetic peptide

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Disease Domain	Count

Endocrinology and Metabolic Disease	2
Neoplasms	2
Nervous System Diseases	1

Top 5 Drug Type	Count

Antibody	3
Small molecule drug	2
Synthetic peptide	1

Top 5 Target	Count

KRAS(GTPase KRas)	1

Human malignant melanoma is the most aggressive type of skin cancer with high metastatic ability. Despite several traditional therapies, the mortality rate remains high. Lactobacillus plantarum (L. plantarum), a species of lactic acid bacteria (LAB), is being studied for human health, including cancer treatment. However, few studies have elucidated the relationship between L. plantarum extract and human malignant melanoma. To investigate the effects of L. plantarum on human melanoma cells, A375 human melanoma cells were used and treated with L. plantarum L-14 extract. After the treatment, viability, migration ability, molecular changes of migration- and apoptosis-related genes, and the location of cytochrome c was evaluated. The L-14 extract inhibited the viability, migration of A375 cells as well as reduced expression of migration-related genes. In addition, it was confirmed that the L-14 extract induced intrinsic apoptosis in A375 cells. This study demonstrated that the L-14 extract exerted anticancer effects on A375 cells. Therefore, these data suggest that the L-14 extract is worth studying for the development of melanoma drugs using LAB.

International Journal of Molecular SciencesQ2 · BIOLOGY

Exopolysaccharide Isolated from Lactobacillus plantarum L-14 Has Anti-Inflammatory Effects via the Toll-Like Receptor 4 Pathway in LPS-Induced RAW 264.7 Cells

Q2 · BIOLOGY

ArticleOA

Author: Park, Sangkyu ; Kwon, Mijin ; Kwon, Oh-Hee ; Roh, Sangho ; Lee, Jaehoon ; Seo, Jeongmin

Inflammation is a biological response of the immune system to defend the body from negative stimulation. However, the excessive inflammatory response can damage host tissues and pose serious threats. Exopolysaccharide (EPS), one of the postbiotics, is secreted from lactic acid bacteria. Although many studies have described the beneficial effects of EPS, such as its anti-inflammatory and anti-oxidant effects, its underlying mechanisms have remained to be poorly understood. Thus, we identified that EPS obtained from Lactobacillus plantarum L-14 was a homogeneous polysaccharide primarily comprised of glucose. To examine these anti-inflammatory effects, an inflammatory response was induced by lipopolysaccharide (LPS) administration to mouse macrophage RAW 264.7 cells that were pretreated with EPS. The anti-inflammatory effects of EPS were identified by analyzing the changes within inflammatory markers at the molecular level. We demonstrate here that EPS suppressed proinflammatory mediators, such as cyclooxygenase-2, interleukin-6, tumor necrosis factor-α, and interleukin-1β, and downregulated the expression of an inducible nitric oxide synthase known to lead to oxidative stress. It was also confirmed that EPS had anti-inflammatory effects by blocking the interaction of LPS with Toll-like receptor 4 (TLR4), as demonstrated by using the known TLR4 inhibitor TAK-242. In addition, we found that EPS itself could suppress the expression of TLR4. Consequently, our data suggest that EPS can be a potential target for the development of natural product-derived medicine for treating inflammatory diseases related to TLR4.

100 Deals associated with NeoRegen Biotech Co.,Ltd

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100 Translational Medicine associated with NeoRegen Biotech Co.,Ltd

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Pipeline

Pipeline Snapshot as of 21 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

6

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

NR-RP-K002	Cicatrix, Hypertrophic More	Discovery
MB-OG15	Osteochondrodysplasias More	Discovery
NR-A-M001	Dystrophy, Macular More	Discovery
NR-AR-B001	Brain Diseases More	Discovery
NR-AR-C010 ( KRAS )	KRAS mutant Colorectal Cancer More	Discovery