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Last update 24 Jun 2025
Hanoi Medical University
Last update 24 Jun 2025
Overview
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100 Clinical Results associated with Hanoi Medical University
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31 Dec 2025Global Health Action
Prevalence and risk factors of gestational diabetes mellitus among pregnant women in northern Vietnam: a cross-sectional study
Article
Author: Gammeltoft, Tine M. ; Le, Hieu Minh ; Nguyen, Dang Kien ; Nguyen, Xuan Bai ; Vinter, Christina A. ; Meyrowitsch, Dan W. ; Bygbjerg, Ib Christian ; Thi Dang, Ngoc-Anh ; Rasch, Vibeke ; Nguyen, Thi Ai ; Søndergaard Linde, Ditte ; Søndergaard, Jens ; Quang Nguyen, Bay ; Duc Nguyen, Thanh
BACKGROUND:
Gestational diabetes mellitus (GDM) increases adverse neonatal and maternal outcomes. Understanding the prevalence and risk factors of GDM is necessary to plan health care interventions and policy.
OBJECTIVE:
To determine the prevalence and risk factors of GDM in Thai Binh, Vietnam.
METHODS:
A cross-sectional study was conducted in two health facilities in Thai Binh, Vietnam, with the participation of 1,106 pregnant women. Women were recruited at their first antenatal care visit where face-to-face interviews about socioeconomic and reproductive factors were performed. A 2-hour 75 g oral glucose tolerance test was conducted at 24-28 weeks of gestation. GDM was diagnosed according to the World Health Organization 2013 criteria. Logistic regression analyses were used to assess the factors associated with GDM.
RESULTS:
The prevalence rate of GDM was 27.1%. Multivariate logistic regression analysis showed maternal age from 25 to 34 (adjusted OR 2.0; 95%CI 1.3-2.9), maternal age ≥ 35 (adjusted OR 3.0; 95%CI 1.7-5.4), pregestational body mass index ≥ 23 (adjusted OR 1.6; 95%CI 1.1-2.3), family history of diabetes (adjusted OR 1.9; 95%CI 1.3-2.9), fertility treatment (adjusted OR 2.3; 95%CI 1.3-3.8), and previous GDM (adjusted OR 3.1; 95%CI 1.4-6.9) were associated with increased odds of GDM.
CONCLUSIONS:
More than one-fourth of pregnant women in Thai Binh, Vietnam, may have GDM. Advanced maternal age, high pregestational body mass index, family history of diabetes, and previous GDM were associated with increased risk of GDM. Additionally, fertility treatment appears to be strongly associated with an increased risk of GDM.
31 Dec 2025Aging Male
Association of testicular histopathology with sperm retrieval success rates in men with idiopathic non-obstructive azoospermia
Article
Author: A. Jannini, Emmanuele ; Dinh Huu, Viet ; Nguyen Cao, Thang ; Nguyen Hoai, Bac
INTRODUCTION:
Infertility is a major public health issue, with male factors alone contributing to 20-30% of cases. Non-obstructive azoospermia (NOA) is the most severe form, and although techniques like microdissection testicular sperm extraction (mTESE) offer hope, it remains challenging due to its uncertain causes. This study investigates the correlation between testicular histopathology and clinical parameters to enhance sperm retrieval (SR) prediction.
MATERIALS AND METHODS:
We reviewed 57 azoospermic men from Hanoi Medical University Hospital, recruited between January 2021 and September 2023. Inclusion criteria were confirmed azoospermia and exclusion of known NOA causes. All underwent mTESE with testicular biopsies classified into four histopathological patterns.
RESULTS:
The patients' mean age was 31.75 ± 5.19 years. SR was successful in 19.3% (11/57). Higher follicle-stimulating hormone (FSH) levels were noted in SR-positive men (p = 0.02). Sertoli cell-only syndrome (SCOS) was the most common pattern. While we found a significant difference in SR rate between testicular histopathology, multivariate analysis showed no strong association. However, FSH levels were predictive of histopathology patterns.
CONCLUSIONS:
Idiopathic NOA (iNOA) represents over 60% of azoospermia cases. mTESE remains the gold standard, and FSH levels may help predict testicular histopathology patterns and improving patients prognosis of SR outcomes.
31 Dec 2025Expert Review of Vaccines
Safety profile of self-amplifying mRNA SARS-CoV-2 vaccine ARCT-154 in adults: a pooled phase 1/2/3 randomized clinical study
Article
Author: Smolenov, Igor ; Hawkes, Alia ; Nguyen, Van Thu ; Parker, Suezanne ; Verhoeven, Carole ; Thi Le Tran, Ly ; Van Chu, Men ; Pham, Ha Thai ; Baccarini, Carmen ; Van Nguyen, Thang ; Trinh, Quang Vinh ; Le, Vy Thi Tuong ; Van Pham, Anh Thi ; Luong, Quang Chan ; Nnah, Ekpeno ; Ta, Van Thanh ; Nguyen, Xuan-Hung ; Ngoc Dang, Mai Thi ; Nguyen, Anh Ngoc ; Nguyen, Toan Trong ; Nguyen, Thuong Vu ; Ho, Nhan Thi ; Pham, Hung Ngoc ; Walson, Judd L ; Dao, Giang Duc
BACKGROUND:
Public health concerns due to ongoing emergence of SARS-CoV-2 variants necessitates further development of improved COVID-19 vaccines. One major innovation are self-amplifying mRNA vaccines, such as ARCT-154 (Arcturus Therapeutics, Inc.), which induces superior immunogenicity compared with conventional mRNA in terms of magnitude, breadth and persistence of neutralizing antibodies.
RESEARCH DESIGN AND METHODS:
In a pivotal placebo-controlled trial in Vietnam combining phase 1, 2 and 3 cohorts, over 17,000 adults received at least one dose of ARCT-154. Here, we report the safety and reactogenicity observations made.
RESULTS:
ARCT-154 elicited more local reactions than the saline placebo, most reports of injection site pain were mild/moderate with only a few reporting severe pain. Most frequent solicited adverse events were fatigue, myalgia, headache, arthralgia and chills. Solicited local and systemic reactogenicity resolved within 7 days. Long-term follow-up has not revealed any safety concerns, with no reports of myocarditis or pericarditis. Acceptable tolerability of ARCT-154 was also observed in older participants and in those liable to severe consequences of COVID-19 due to underlying medical conditions. No serious consequences occurred in several pregnancies reported after vaccination, with normal outcomes when followed to term.
CONCLUSIONS:
Data from this large trial suggest that ARCT-154 is safe and well tolerated.
100 Deals associated with Hanoi Medical University
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