[Translation] Phase Ia safety, tolerability, pharmacokinetics and pharmacodynamics study of recombinant anti-CD20 humanized monoclonal antibody injection
1.评估本品在CD20阳性B细胞非霍奇金淋巴瘤患者中的耐受性和安全性,确定DLT、MTD。 2.评估本品在CD20阳性B细胞非霍奇金淋巴瘤患者中的药代动力学、药效动力学和免疫原性。 3.评估本品在CD20阳性B细胞非霍奇金淋巴瘤患者中的客观反应率。
[Translation] 1. Evaluate the tolerability and safety of this product in patients with CD20-positive B-cell non-Hodgkin's lymphoma, and determine the DLT and MTD. 2. Evaluate the pharmacokinetics, pharmacodynamics and immunogenicity of this product in patients with CD20-positive B-cell non-Hodgkin's lymphoma. 3. Evaluate the objective response rate of this product in patients with CD20-positive B-cell non-Hodgkin's lymphoma.