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APP(Beta amyloid A4 protein)	1

Magnesium alloys have attracted significant interest in bone tissue engineering because of their beneficial characteristics. However, their widespread application is still hindered by rapid degradation rates and the challenges associated with real-time monitoring. Given that up-conversion nanoparticles (UCNPs) possess imaging capabilities and that nanofillers can enhance the degradation behavior of these materials, we have utilized UCNPs to develop metal matrix composites. Specifically, we employed powder metallurgy technology to prepare up-conversion nanoparticles/magnesium/zinc composites (UCNPs/Mg/Zn). We systematically studied the mechanical properties, degradation behavior, biocompatibility, osteogenic activity, and degradation monitoring of the composite. In vivo and in vitro degradation studies demonstrated that the composite containing 10 % UCNPs, 86 % Mg, and 4 % Zn (10U-Mg-4Zn) gradually degrades over time, with luminous intensity initially increasing from weak to strong before subsequently diminishing. Furthermore, compared to complexes containing 96 % Mg and 4 % Zn (Mg4Zn), the degradation rate of the 10U-Mg-4Zn complex was significantly reduced, while cytocompatibility improved and osteogenic differentiation of mouse embryonic osteoblasts (MC3T3-E1) was markedly enhanced. Therefore, the 10U-Mg-4Zn composite not only demonstrates good degradation performance and supports bone tissue regeneration but also facilitates the monitoring of material degradation, thereby providing a novel method for material evaluation and a fresh perspective for developing new magnesium matrix composites.

01 May 2025·Steroids

Antimicrobial diterpenoids from Rosmarinus officinalis

Article

Author: Liu, Jia-Chen ; Xu, Jia ; Zi, Jiachen ; Shang, Xiao-Ya ; Wang, Xin ; Xu, Qing-Jiang

Three new diterpenoids, 12,16-epoxy-11-hydroxy-17(15 → 16)-abeo-abieta-8,11,13-trien-7-one (1), 7,12-dihydroxy abieta-6,8,10(5),11,13-quien-20-oic acid 1,20-lactone (2), labda-5(10),13(E)-dien-15-ol (11), one new natural product (2E,6E)-3,7-dimethyl-9-[(1S,6R)-1,2,6-trimethylcyclohex-2-enyl]nona-2,6-dien-1-ol (16) and thirteen known compounds were isolated and elucidated from the excellent antimicrobial active fractions of Rosmarinus officinalis ethanol extract. The structures of the isolated compounds were determined by spectral data analysis and combined with literature reports. Among them, monocyclic diterpenoids (16 and 17) were discovered from rosemary for the first time. All isolated compounds were tested for antimicrobial activity against four strains (B. subtilis, S. aureus, P. aeruginosa, and Fusarium spp.), with six compounds showing very strong inhibitory activity against B. subtilis and four compounds showing strong inhibitory activity against P. aeruginosa.

100 Deals associated with Beijing Union University

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100 Translational Medicine associated with Beijing Union University

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Pipeline

Pipeline Snapshot as of 31 Aug 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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