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Nervous System Diseases

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Technology Platform

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Most frequently developed targets

Disease Domain	Count

Nervous System Diseases	3
Neoplasms	3

Top 5 Drug Type	Count

Small molecule drug	3

Top 5 Target	Count

GSK-3(Glycogen synthase kinase-3)	2
GSK-3α(glycogen synthase kinase 3 alpha)	1

The battery lifetime of Elec. vehicles (EVs) is affected by hot temperatures and high charging and discharging effective battery current.Hybrid energy storage systems (HESS) coupling the best attributes of the battery with supercapacitors (SCs) help extend the battery lifetime and improve the EV storage performances.The key to a successful HESS at extending the battery lifetime is to adopt the appropriate Energy Management System (EMS) that ensures the best power sharing between battery and SCs.This paper proposes an innovative real-time optimization-based EMS with low computational costs and high adaptability to variable and commute driving profiles.The proposed EMS is organized in two levels.The lower level implements a rule-based frequency power sharing control.The upper level performs Reinforcement Learning (RL) optimizations to learn and adapt the best power sharing configuration considering real-time information and actual load conditions.An exptl. test bench is developed and exptl. measurements are conducted.The obtained results confirmed the effectiveness of the proposed EMS to provide the best trade-offs between simple implementation, computation time, solution optimality, real-time performance, and good adaptation to variable driving conditions.

01 Apr 2025·Journal of Molecular Structure

Investigation on X-ray diffraction, IR, UV-visible, fluorescence, thermogravimetric, DFT studies, and molecular docking approach of a new C6H17.16Cl3CuN3O0.58 complex

Author: Kaabi, Kamel ; Kamisky, Werner ; Lefebvre, Frederic ; Nasr, Cherif Ben ; Timothy, Rawlings A. ; Runde, Musa ; Nbili, Wijdene

In this present investigation, a new C₆H₁₇.₁₆Cl₃CuN₃O_0.58, [CuCl₃(HNAEP)](H₂O)_0.58, with HNAEP = N-aminoethlpiperazinium, complex was synthesized and the crystallog. study was carried out.X-ray diffraction anal. reveals that the title complex crystallizes in a Monoclinic crystal lattice with the P2₁/n space group.The unit cell dimensions are as follows: a = 8.8932(8) Å, b = 14.7598(12) Å, and c = 9.0534(8) Å, obtained at a temperature of 100(2) K.The purity of the title compound was checked by PXRD.The crystallog. data were also used in the Hirshfeld surface anal., which aimed to investigate the nature and quant. significance of any noncovalent intermol. interactions inside the crystal lattice.The most abundant interaction in the complex is H...H with a percentage abundance of 37.7 %, Cl...H (34.7 %) and H...Cl (23.7 %).Theor. calculations based on d. functional theory (DFT) at the wB97XD/GenECP/Def2-SVP/LanL2DZ method were utilized to understand the structural geometry, Natural Bond Orbital Anal. (NBO) and vibrational spectroscopy of the studied complex.The frontier orbitals and the MEP were visualized using Molekel software with the B3LYP/6-31 + G* method.The novel complex underwent docking against proteins 3J2 N and 4PYP to evaluate its potential antitumor activity and the outcomes reveal that [CuCl₃(HNAEP)](H₂O)_0.58-3J2 N displayed the most favorable binding pose, forming four conventional hydrogen bonds with amino acids at distances of 2.71884 Å, 2.56473 Å, 2.69065 Å, and 2.31048 Å, involving ALA and ASP residues.

04 Mar 2025·Communications in Statistics - Theory and Methods

Orthogonal systems based stable estimator for non parametric regression problems

Author: Saber, Asma Ben ; Karoui, Abderrazek

1

News (Medical) associated with Carthage University

10 Feb 2018

·www.bioportfolio.com

Global Geotextile Market Analysis 20122017 and Forecast 20182023 [Report Updated: 24012018] Prices from USD $2980

Summary The global Geotextile market will reach xxx Million USD in 2017 and CAGR xx% 20112017. The report begins from overview of Industry Chain structure, and describes industry environment, then analyses market size and forecast of Geotextile by product, region and application, in addition, this report introduces market competition situation among the vendors and company profile, besides, market price analysis and value chain features are covered in this report. Product Type Coverage Market Size Forecast, Major Company of Product Type etc.: Woven Nonwoven Company Coverage Sales Revenue, Price, Gross Margin, Main Products etc.: Koninklijke Ten Cate GSE Environmental Terrafix Leggett Platt Propex Operating Company WINFAB Geofabrics Australasia Tessilbrenta Fibertex Nonwovens Northwest Linings Carthage Mills Layfield Fibertex South Africa TYPAR Geosynthetics Geofabrics New Zealand Nilex Terram Application Coverage Market Size Forecast, Different Demand Market by Region, Main Consumer Profile etc.: Dams Roads Airports Construction Others Region Coverage Regional Output, Demand Forecast by Countries etc.: North America Europe AsiaPacific South America Middle East Africa

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Pipeline

Pipeline Snapshot as of 02 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

3

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