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Overview

CONTEXTRice bran arabinoxylan compound (RBAC) is a natural immunomodulator with anticancer properties.OBJECTIVEThis study critically evaluates the available evidence on the biological pathways of RBAC and its effects on cancer treatment.METHODSThis secondary analysis of a scoping review includes studies evaluating the mechanisms of RBAC on healthy or malignant cells, animal models, or humans for cancer prevention or treatment. Data from randomized controlled trials on survival and quality of life outcomes were subjectd to meta analysis.RESULTSThe evidence synthesis was based on 38 articles. RBAC exhibited antitumor properties by promoting apoptosis and restoring immune function in cancer patients to enhance inflammatory and cytotoxic responses to block tumorigenesis. RBAC works synergistically with chemotherapeutic agents by upregulating drug transport. In a clinical trial, combining RBAC with chemoembolization in treating liver cancer showed improved response, reduced recurrence rates, and prolonged survival. RBAC also augments the endogenous antioxidant system to prevent oxidative stress and protect against radiation side effects. In addition, RBAC has chemoprotective effects. Animals and humans have exhibited reduced toxicity and side effects from chemotherapy. Meta analysis indicates that RBAC treatment increases the survival odds by 4.02-times (95% CI: 1.67, 9.69) in the first year and 2.89-times (95% CI: 1.56, 5.35) in the second year.CONCLUSIONRBAC is a natural product with immense potential in cancer treatment. Additional research is needed to characterize, quantify, and standardize the active ingredients in RBAC responsible for the anticancer effects. More well-designed, large-scale clinical trials are required to substantiate the treatment efficacies further.

30 Sep 2024·Journal of the Korean Society of Food Science and Nutrition

Antioxidant and Anti-allergic Effects of Bioprocessed Brown Seaweeds (Ecklonia cava and Ecklonia stolonifera)

Author: Lee, Wha Young ; Lee, Kyung Hee ; Lee, Sang Jong ; Hwang, Woon Sang ; Kim, Sung Phil ; Kim, Jeanman

Brown seaweeds harvested from the ocean are widely consumed in Asian countries as health-promoting medicinal foods.The objective of the present study was to evaluate the antioxidant and anti-allergic effects of a new functional food produced by bioprocessing edible algae Ecklonia cava and Ecklonia stolonifera, which are edible, perennial, widely distributed brown marine algae rich in polyphenols, including dieckol.Therefore, we investigated the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activities of E. cava (EC), E. stolonifera (ES), fermented E. cava (FEC), and fermented E. stolonifera (FES).We also confirmed that EC, FEC, ES, and FES could activate macrophages in a dose-dependent manner.In addition, the FEC and FES treatments inhibited thymic stromal lymphopoietin production, degranulation, and IgE (IgE) production in mast cells and B cells.Taken together, FEC and FES are substances that can be used effectively for various allergic reactions, not only because of their antioxidant and anti-allergic activities, but also because of the addnl. IgE production inhibitory activity resulting from bioprocessing.

31 May 2023·Journal of the Korean Society of Food Science and Nutrition

Assessment of Bioactive Compounds and Anti-Atopic Effect of Ecklonia cava and Ecklonia stolonifera by Bioconversion