Hainan Selection Pharmaceutical Co. Ltd.

This study investigates whether there are differences in the absorption rate and extent between the test formulation gabapentin tablets (Hainan Serik Pharmaceutical Co., Ltd., specification: 0.6g) and the reference formulation gabapentin tablets (trade name: Neurontin®; Viatris Specialty LLC, specification: 600mg) administered orally once in fasting and postprandial states in healthy study participants. It also evaluates the bioequivalence of the test and reference formulations under fasting and postprandial administration and observes the safety of the test and reference formulations in healthy study participants.

Primary Objectives: To compare the absorption extent and rate of a test product, Flurbiprofen Gel Patch (provided by Hainan Selike Pharmaceutical Co., Ltd., with a 40 mg flurbiprofen patch (13.6 cm × 10 cm area and 12 g paste content)) and a reference product, Flurbiprofen Gel Patch (provided by Mikasa Seiyaku Co., Ltd., with a 40 mg flurbiprofen patch (13.6 cm × 10 cm area and 12 g paste content), in healthy Chinese subjects, and to evaluate the bioequivalence of the two products. Secondary Objectives: 1) To evaluate the safety of the test and reference products in healthy Chinese subjects; 2) To evaluate the adhesiveness of the test and reference products during use in healthy Chinese subjects; and 3) To evaluate the skin irritation of the test and reference products in healthy Chinese subjects.

Main study objectives: To investigate the relative bioavailability of the test preparation Olopatadine Hydrochloride Granules [Specification: 2.5mg (0.5%), provided by Hainan Celic Pharmaceutical Co., Ltd.] and the reference preparation Olopatadine Hydrochloride Granules [Trade name: Allelock®, Specification: 2.5mg (0.5%), produced by Kyowa Kirin Co., Ltd.] in healthy adult Chinese subjects after a single oral dose (fasting/postprandial), analyze the pharmacokinetic parameters of the two preparations, and evaluate the bioequivalence of the two preparations. Secondary study objectives: To evaluate the safety of the test preparation and the reference preparation in healthy adult Chinese subjects after a single oral dose (fasting/postprandial).