Hainan Selection Pharmaceutical Co. Ltd.

The arginine ibuprofen tablets (specification: 0.4g) produced by Hainan Zambang Pharmaceutical Co., Ltd. were used as the reference preparation to evaluate the bioequivalence of arginine ibuprofen tablets (specification: 0.4g) developed by Hainan Celik Pharmaceutical Co., Ltd. with the reference preparation.

Primary objective: To compare the differences in the extent and rate of absorption of loxoprofen sodium gel patch (100 mg/patch) produced by Hunan Fangsheng Pharmaceutical Co., Ltd. and loxoprofen sodium gel patch (trade name: LOXONIN PAP ®, specification: 100 mg/patch) certified by Lead Chemical Co., Ltd. in Chinese healthy subjects under fasting administration conditions using a single-center, randomized, open, two-drug, two-period crossover, fasting trial design, and evaluate bioequivalence. Secondary objectives: 1) To evaluate the safety of the test and reference preparations in Chinese healthy subjects; 2) To evaluate the adhesion of the test and reference preparations during medication in Chinese healthy subjects; 3) To evaluate the skin reactivity of the test and reference preparations in Chinese healthy subjects.

Primary objective: To compare the differences in the absorption degree and absorption rate of flurbiprofen gel patch (40 mg/patch) provided by Hainan Celic Pharmaceutical Co., Ltd. and flurbiprofen gel patch (trade name: ZEPOLAS®, specification: 40 mg/patch) certified by Mikasa Pharmaceutical Co., Ltd. in Chinese healthy population under fasting administration conditions using a single-center, randomized, open, two-period crossover, fasting trial design, and evaluate bioequivalence. Secondary objectives: 1) To evaluate the safety of the test preparation and the reference preparation in Chinese healthy subjects; 2) To evaluate the adhesion of the test preparation and the reference preparation during medication in Chinese healthy subjects; 3) To evaluate the skin reactivity of the test preparation and the reference preparation in Chinese healthy subjects.