Hainan Selection Pharmaceutical Co. Ltd.

Primary Objectives: To compare the absorption extent and rate of a test product, Flurbiprofen Gel Patch (provided by Hainan Selike Pharmaceutical Co., Ltd., with a 40 mg flurbiprofen patch (13.6 cm × 10 cm area and 12 g paste content)) and a reference product, Flurbiprofen Gel Patch (provided by Mikasa Seiyaku Co., Ltd., with a 40 mg flurbiprofen patch (13.6 cm × 10 cm area and 12 g paste content), in healthy Chinese subjects, and to evaluate the bioequivalence of the two products. Secondary Objectives: 1) To evaluate the safety of the test and reference products in healthy Chinese subjects; 2) To evaluate the adhesiveness of the test and reference products during use in healthy Chinese subjects; and 3) To evaluate the skin irritation of the test and reference products in healthy Chinese subjects.

Main study objectives: To investigate the relative bioavailability of the test preparation Olopatadine Hydrochloride Granules [Specification: 2.5mg (0.5%), provided by Hainan Celic Pharmaceutical Co., Ltd.] and the reference preparation Olopatadine Hydrochloride Granules [Trade name: Allelock®, Specification: 2.5mg (0.5%), produced by Kyowa Kirin Co., Ltd.] in healthy adult Chinese subjects after a single oral dose (fasting/postprandial), analyze the pharmacokinetic parameters of the two preparations, and evaluate the bioequivalence of the two preparations. Secondary study objectives: To evaluate the safety of the test preparation and the reference preparation in healthy adult Chinese subjects after a single oral dose (fasting/postprandial).

Main study objectives: To investigate the relative bioavailability of the test preparation Ezetimibe tablets (specification: 10 mg, produced by Hainan Celic Pharmaceutical Co., Ltd.) and the reference preparation Ezetimibe tablets (trade name: Yishichun®, specification: 10 mg, produced by MSD International GmbH (Singapore Branch)) in healthy adult Chinese subjects after a single oral administration on an empty stomach/after a meal, analyze the pharmacokinetic parameters of the two preparations, and evaluate the bioequivalence of the two preparations. Secondary study objectives: To evaluate the safety of the test preparation and the reference preparation in healthy adult Chinese subjects after a single oral administration on an empty stomach/after a meal.