Reference Values of Carotid Intima-media Thickness and Arterial Stiffness in Chinese Adults Based on Ultrasound Radio Frequency Signal: A Nationwide, Multicenter Study

This study intends to establish the normal reference values of carotid artery intima-media thickness and vascular elasticity of Chinese adults based on ultrasound radio frequency technology through a multi-center large-sample study, which provides important information for the risk prediction and prognosis evaluation of Chinese adults' cardiovascular disease.

Start Date01 May 2021

Sponsor / Collaborator

Tangdu Hospital

[+20]

ChiCTR2100043255

/ RecruitingEarly Phase 1IIT

Experimental study on treatment of dry eye in mice with exosomes from human cord blood

Start Date15 Mar 2021

Sponsor / Collaborator

Xi'an No.1 Hospital

100 Clinical Results associated with Xi'an No.1 Hospital

0 Patents (Medical) associated with Xi'an No.1 Hospital

247

Literatures (Medical) associated with Xi'an No.1 Hospital

01 Aug 2025·Cellular Signalling

Leptin attenuates diabetic cardiomyopathy-induced cardiac remodeling via regulating cGAS/STING signaling and Opa1-mediated mitochondrial fusion

Article

Author: Li, Tonghua ; Ren, Yang ; Zhang, Xuejiao ; Hao, Chunyuan ; Wang, Junzhe ; Gao, Weihua ; Zhang, Yuyang

PURPOSEThis investigation seeks to elucidate the contribution of leptin to the pathogenesis of diabetic cardiomyopathy (DCM).METHODSMice were rendered diabetic through the administration of streptozotocin (STZ). Leptin was delivered via subcutaneously implanted osmotic pumps. Assessments of cardiac performance, hypertrophy, and fibrosis were conducted using echocardiography, Hematoxylin and Eosin (H&E), Wheat Germ Agglutinin (WGA), and Masson trichrome staining. Myocardial apoptosis and oxidative stress were quantified through TUNEL assay and biochemical markers of oxidative stress, including Malondialdehyde (MDA), 4-Hydroxynonenal (4-HNE), and 3-Nitrotyrosine (3NT). Mitochondrial structure was examined using Transmission Electron Microscopy (TEM). Primary neonatal cardiomyocytes were subjected to high glucose (HG) conditions. The fluorescent indicators MitoTracker Green and MitoSOX Red were employed to evaluate mitochondrial morphology and function within the cardiomyocytes.RESULTSMice with diabetes displayed marked cardiac hypertrophy and fibrosis, as indicated by H&E, WGA, and Masson staining. The administration of leptin significantly mitigated the cardiac pathological manifestations in diabetic mice. Leptin increased the expression of Opa1 and enhanced mitochondrial fusion and function in cardiomyocytes exposed to HG. The cGAS/STING signaling pathway may serve as a pivotal intermediary for leptin to facilitate Opa1-driven mitochondrial fusion.CONCLUSIONSLeptin appears to safeguard against hyperglycemia-induced mitochondrial oxidative damage and DCM by modulating the cGAS/STING signaling cascade and Opa1-mediated mitochondrial fusion. These results propose that leptin could be a promising agent for promoting mitochondrial fusion and preventing diabetes-associated cardiac pathologies.

01 Apr 2025·Journal of Hypertension

Structural and load-dependent arterial stiffness across the adult life span

Article

Author: Zhou, Qing ; Yang, Hengli ; Zhang, Chaoxue ; Chen, Wu ; Xing, Changyang ; Ding, Yunchuan ; Li, Hua ; Wang, Xiangzhu ; Qiu, Shaodong ; Wu, Yu ; Zheng, Yu ; Xie, Mingxing ; Yan, Guozhen ; Zhao, Cheng ; Sun, Xiaofeng ; Xu, Lei ; Mao, Yinjuan ; Zhan, Weiwei ; Gu, Ying ; Ma, Chunyan ; Yang, Hong ; Wang, Yingli ; Jiang, Tianan ; Xie, Xiujing ; Guan, Xiangping ; Li, Fan ; Zhan, Xiaojun ; Li, Jinsong ; Zhou, Qi ; Mu, Yuming ; Yuan, Lijun

Background:The arterial stiffening is attributed to the intrinsic structural stiffening and/or load-dependent stiffening by increased blood pressure (BP). The respective lifetime alterations and major determinants of the two components with normal aging are not clear.Methods:A total of 3053 healthy adults (1922 women) aged 18–79 years were enrolled. The carotid intima–media thickness, diameter, and local BPs were automatically determined by the radio frequency ultrasound system. The Peterson and Young elastic moduli were then calculated to represent total arterial stiffness. Structural stiffness was recalculated at a reference BP of 120/80 mmHg with established models. Load-dependent stiffness was the difference between total and structural stiffness.Results:Both structural and load-dependent stiffness increased with aging, with much larger changes in the structural components. The age-related increasing rates were higher in women for the structural stiffness than men (P < 0.05), but similar for the load-dependent stiffness. The clinical characteristics and arterial stiffness were widely correlated, but most correlations were quite weak (r < 0.3) other than BPs. Multiple regression analyses adjusted for sex, age and other clinical correlates showed that structural stiffness increased with pulse pressure (PP) and load-dependent stiffness increased with mean arterial pressure (MAP), respectively.Conclusion:The age-related arterial stiffening is mainly caused by the intrinsic structural stiffening, which demonstrated significant age–sex interaction. BPs were the major clinical determinants of arterial stiffness, with PP and MAP associated with different arterial stiffness components. The differentiation of the structural and load-dependent arterial stiffness should be highlighted for the optimal vascular health management.

01 Apr 2025·Sleep Medicine

The up-regulation of PTBP1 expression level in patients with Insomnia by senile dementia and promote cuproptosis of nerve cell by SLC31A1

Article

Author: Han, Bin ; Gao, Lan ; Meng, Kun ; Zhao, Xiaoli ; Wang, Jing

Alzheimer's disease (AD), often referred to as the modern-day scourge, stands as a significant health challenge characterized by high rates of disability and mortality, particularly among the geriatric population. Thus, the present study investigated the precise details of PTBP1 involvement in cuproptosis of nerve cell of patients with Insomnia by senile dementia (ISD). Patients with ISD, early mild cognitive impairment (EMCI) and Normal healthy volunteers were obtained. In the context of ISD, the elevated PTBP1 mRNA expressions were observed in patient samples, correlating positively with diminished cognitive function as measured by the Mini-Mental State Examination (MMSE) and increased geriatric depression scale scores. The pivotal role of PTBP1 was further underscored by its inhibitory effects in a mice model, which prevented the development of senile dementia, and its influence on neuronal cell proliferation and ROS-induced oxidative stress in vitro. Additionally, PTBP1's regulatory capacity on the cuproptosis of nerve cells and its modulation of SLC31A1 expression, through effects on ubiquitination, were revealed. The stability of PTBP1, critical for its function, was enhanced by the m6A modification mediated by METTL3, highlighting a complex regulatory network in the pathogenesis of ISD. These data confirmed that PTBP1 plays a pivotal role in promoting the oxidative response and cuproptosis in Alzheimer's disease models via the SLC31A1 pathway. The findings suggest that PTBP1 could serve as a potential biomarker for the diagnosis and prognostic evaluation of ISD and AD, paving the way for the development of novel therapeutic strategies targeting this protein.

100 Deals associated with Xi'an No.1 Hospital

100 Translational Medicine associated with Xi'an No.1 Hospital

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