Delving into the Latest Updates on Galileo Pharmaceuticals, Inc. with Synapse

Overview

Although most screening for new drug leads is being directed at known or emerging molecular targets, there has been a renaissance in screening based on changes in cell or organismal phenotypes. Phenotype-based screening is accompanied by the challenge of identifying the molecular target or targets bound by the drug leads and responsible for their pharmacological activity. A variety of technologies and approaches are being explored for target identification after phenotypic screening. Direct approaches employing affinity chromatography, expression cloning and protein microarrays analyze the compound bound to its target. Indirect approaches are based on comparison of the genome-wide activity profile of the compound with databases of the activity profiles of other compounds with known targets or activity profiles following specific genetic changes. This review will use case studies of target identification efforts and highlight the advantages and disadvantages of the various approaches to target identification after phenotypic screening.

01 Mar 2002·Current opinion in drug discovery & development

Plant cell cultures as a source of bioactive small molecules.

Article

Author: Stafford, Angela M

Plants have provided some of our most important pharmaceuticals and are a continuing source of novel bioactive molecules for drug development. Cell suspension cultures of higher plants are a complementary source of novel chemistry with significant advantages over whole plants, including plasticity of expression and re-accessibility. With an emphasis on recent progress, the use of plant cell cultures for both new lead discovery and as a route to the production of known bioactives will be described. Developments in strategies that can be applied to facilitate future success in the area are discussed.

Current Opinion in Drug Discovery & Development

Plant cell cultures as a source of bioactive small molecules

Author: Stafford, Angela M.

A review, with referencesPlants have provided some of our most important pharmaceuticals and are a continuing source of novel bioactive mols. for drug development.Cell suspension cultures of higher plants are a complementary source of novel chem. with significant advantages over whole plants, including plasticity of expression and re-accessibility.With an emphasis on recent progress, the use of plant cell cultures for both new lead discovery and as a route to the production of known bioactives will be described.Developments in strategies that can be applied to facilitate future success in the area are discussed.

100 Deals associated with Galileo Pharmaceuticals, Inc.

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100 Translational Medicine associated with Galileo Pharmaceuticals, Inc.

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Pipeline

Pipeline Snapshot as of 14 Dec 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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