M J Biopharm Pvt Ltd.

A semisolid preparation (ointment, gel, cream) of Thiocolchicoside which is a centrally acting skeletal muscle relaxant was developed for the effective treatment of muscle spasm.Thiocolchicoside has been claimed to posses GABA mimetic & glycinergic actions in other way can say that Thiocolchicoside is a gama-aminobutyric receptor agonist.Thiocolchiocoside activity can be ascribed to its ability of interacting with strychnine sensitive glycine receptors & therefore that compounds endowed with the glycino-mimetic activity can be used in rheumatol.-orthopedic field for their muscle relaxant properties.It is widely prescribed for treatment of muscle spasm, cramps, musculoskeletal & neuromuscular disorder.Thiocolchicoside is available in market in the form of capsules & injection.The major problem associated with Thiocolchicoside is its bioavailability which is very low i.e. 25% only so in order to minimize drug loss due to first pass metabolism, and overcome problem associated with low bioavailability drug there is need to formulate semisolid preparationThiocolchicoside ointment, gel & cream were developed and comparative study of their drug release.In vitro release of Thiocolchicoside from the three bases i.e., ointment, gel, cream to an aqueous receptor phase through Whatman filter paper number41 as well as mice skin was monitored spectrophotometrically at a wavelength of 259 nm.In vitro release study results showed that the steady state fluxes of the drug from vehicles rank according to the following order: ointment > gel > cream.Ointment base showed considerably higher drug release than other vehicles.

Bi-layer tablets of Piracetam and Vinpocetine, were formulated so that synergistic effect of this combination could be used for the effective treatment of Alzheimer Disease.Wet granulation process was used for the formulation of both layers and the final film coated tablets were evaluated for the thickness, weight variation, hardness, friability, disintegration time, dissolution study.Among the formulation, tablets of batch V2 of vinpocetine & batch P3 of piracetam was taken as optimized formula due to its higher rate of dissolution and complied all the other parameters with the official specifications.The stability study of the selected formulations was done at 40°C and 75% RH for 3 mo.Thus, Piracetam, Vinpocetine Bi-layer tablets can be prepared successfully as it satisfies all the criteria as a Bi-layered tablet and would be alternative to the currently available conventional tablets.