Zhejiang Haigetang Pharmaceutical Co., Ltd.

Main purpose: According to the relevant provisions of the bioequivalence test, the tulobuterol patch (1 mg/patch) developed by Zhejiang Haigetang Pharmaceutical Co., Ltd. was used as the test preparation, and the tulobuterol patch (trade name: Amidie®, 1 mg/patch) produced by Nitto Denko Corporation was used as the reference preparation. After taking 1 mg of each, the pharmacokinetic parameters were estimated according to the in vivo time course of tulobuterol, and the two preparations were preliminarily evaluated to see whether they were bioequivalent, providing a basis for revising the design of the formal test plan; the pharmacokinetic properties of the drug were preliminarily understood, providing a basis for setting up the blood collection points for the formal test; and the concentration range of the drug was understood, providing a reference for optimizing the detection methodology of the formal test. Secondary purpose: To evaluate the safety, skin adhesion and skin irritation of the tulobuterol patch in healthy subjects.