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Overview

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Nervous System Diseases

Neoplasms

Endocrinology and Metabolic Disease

Recombinant polypeptide

Small molecule drug

Fusion protein

Disease domain score

A glimpse into the focused therapeutic areas

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Most frequently developed targets

Disease Domain	Count

Nervous System Diseases	3
Endocrinology and Metabolic Disease	2
Neoplasms	2

Top 5 Drug Type	Count

Small molecule drug	2
Recombinant polypeptide	2
Fusion protein	1
Enzyme	1

Top 5 Target	Count

TRPM8(Transient receptor potential cation channel subfamily M member 8)	2
Plasminogen activators	2
DR5 x VEGFR2	1

Patients with advanced heart failure with preserved ejection fraction (HFpEF) will be randomly assigned in open-label multicenter study to receive triple combination therapy with [angiotensin receptor/neprilysin inhibitor [ARNI] + sodium-glucose cotransporter 2 inhibitor [SGLTi] + mineralocorticoid receptor antagonist [MRA]) or with individualized medical therapy [SGLTi + renin-angiotensin system inhibitor [RASi] [angiotensin receptor blocker [ARB] or angiotensin-converting enzyme inhibitor [ACE-I]), and will be treated for 52 weeks

Start Date18 Feb 2025

Sponsor / Collaborator

Ministry of Health of Russian Federation

[+1]

NCT04424134

/ Unknown statusPhase 3

Open Label Randomized Clinical Trial BromhexIne And Spironolactone For CoronаVirUs Infection Requiring HospiTalization

Patients with mild and severe COVID 19 will be randomized 1:1 into two groups: experimental, which will get bromhexine and spironolactone, and control. Patients will get investigated therapy for ten days. Change in clinical assessment score COVID 19 (CAS COVID 19) between baseline and 12th day will be evaluated as a primary endpoint. Forty-five-day risk of death or mechanical ventilation will also be assessed.

Start Date16 May 2020

Sponsor / Collaborator

Moscow State University Lomonosov

NCT04403243

/ CompletedPhase 2

COLchicine Versus Ruxolitinib and Secukinumab in Open-label Prospective Randomized Trial in Patients With COVID-19

Patients with mild and severe coronavirus disease 2019 (COVID 19) will be randomized 3:1:1:3 into four groups: colchicine, ruxolitinib, secukinumab, and control groups. . Patients will be follow-up during 45 days after randomization. Change in clinical assessment score COVID 19 (CAS COVID 19) between baseline and 12th day will be evaluated as the primary endpoint. Risk of death or mechanical ventilation during 45 days after randomization will also be assessed

Start Date08 May 2020

Sponsor / Collaborator

Moscow State University Lomonosov

100 Clinical Results associated with Moscow State University Lomonosov

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0 Patents (Medical) associated with Moscow State University Lomonosov

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136,635

Literatures (Medical) associated with Moscow State University Lomonosov

01 May 2025·Talanta

Using Agaricus bisporus crude extract in distance based 3D microfluidic paper-based analytical device and spectrophotometric analytical procedures for thiols determination

Article

Author: Morosanova, E I ; Golovacheva, N V ; Morosanova, M A

Novel and simple spectrophotometric and distance based procedures for thiols (L-cysteine, N-acetylcysteine, and glutathione) determination in biological fluids and pharmaceuticals have been proposed based on their inhibitory action on the oxidation of catechol in the presence of Agaricus bisporus crude extract (ABE). The influence of L-glycine, L-alanine, L-proline, L-methionine, L-cystine, ascorbic acid, uric acid, and bilirubin on the thiol determination has been investigated. Uric acid, bilirubin, L-cystine (oxidized thiol), and L-amino acids do not interfere with the determination. The interference of ascorbic acid up to 350 mg/L is eliminated by using Cucumis sativus crude extract (CSE) with ascorbate oxidase activity. Distance based microfluidic paper-based analytical device (DμPAD) has been developed using origami paper device approach and ABE-catechol-3-methyl-2-benzothiazolinone hydrazone (MBTH) system. DμPAD has the 3D structure of three layers: CSE microzone layer, ABE microzone layer, and chemometer layer (catechol + MBTH). This structure allows sequential sample treatment (ascorbic acid oxidation by CSE) and the following introduction of treated sample to ABE and its substrate to perform ABE inhibition. Separate loading of ABE and its substrate allows preventing their interaction prior to sample loading. DμPAD thiol determination is performed by measuring the length of uncolored flow channel, which allows very simple thiol determination and enables complete integration of analytical procedure steps: sample treatment and enzymatic determination with visual signal output. The analytical ranges are (0.3-2.5)∙10^-4 M and (1.1-10.0)∙10^-4 M, the recoveries are 80.5-126.7 % and 92.0-112.0 %, the RSD values are 1.6-19.0 % and 2.7-10.8 %, for spectrophotometric and DμPAD procedures, respectively. Both easy-to-use procedures have been successfully applied to the determination of total thiol content (all free sulfhydryl groups) in synthetic urine and N-acetylcysteine in a pharmaceutical sample. The values found with DμPAD and spectrophotometric procedures are in good agreement with values obtained using Ellman's reagent.

01 Apr 2025·Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mutational interference with oligomerization properties of OCP-related apo- and holoproteins studied by analytical ultracentrifugation

Article

Author: Cremer, Nils ; Moldenhauer, Marcus ; Maksimov, Eugene G ; Friedrich, Thomas ; Sluchanko, Nikolai N ; Koczula, Anna Marta

In this study, the oligomerization pattern of apo- and holoforms of the Orange Carotenoid Protein (OCP) was examined under different conditions such as photoactivation state, concentration, and carotenoid embedment using analytical ultracentrifugation. Furthermore, studies were conducted on OCP constructs carrying point mutations of amino acid residues affecting OCP oligomerization. Our findings reveal that the concentration-dependent dimerization of dark-adapted OCP holoprotein from Synechocystis sp. PCC 6803 can be effectively prevented by the R27L mutation in the OCP-NTD. By introducing the E258R mutation (also in conjunction with R27L) into the OCP-CTD, monomeric OCP apoprotein can be obtained. Additionally, the holoprotein of the dark-adapted OCP-R27L/E258R variant was monomeric, and, supported by size-exclusion chromatography experiments, the photoactivated form of the OCP-R27L/E258R variant was monomeric as well. This variant, which does not oligomerize in either photocycle state, returns from the photoactivated to the dark-adapted state at a significantly faster rate than the OCP wild-type and the R27L mutant thereof. These observations also highlight the crucial interdependence between OCP dimerization in both photocycle states, the lifetime of the photoactive state of OCP, and the kinetics of the OCP photocycle.

01 Apr 2025·Veterinary Research Communications

Extracellular phospholipase, protease and hemolysin production by strains of opportunistic yeasts from the excreta of Mew Gulls breeding in natural and urban habitats

Article

Author: Glushakova, Anna ; Kachalkin, Aleksey

Extracellular hydrolytic activity (phospholipase, protease and hemolysin production) was evaluated in 178 strains of potentially pathogenic ascomycetous (Candida parapsilosis, Candida tropicalis) and basidiomycetous (Rhodotorula mucilaginosa) yeasts isolated from the excreta of Mew Gulls. Two bird colonies, one nesting in a natural habitat and the other in an urban habitat at the landfill, were studied simultaneously during their 7-month breeding season. Significant differences in phospholipase and protease production were found between natural and anthropophized strains. Both virulent activities were higher in strains of potentially pathogenic yeast species isolated from the excreta of Mew Gulls nesting in the anthropogenic habitat near the landfill. No significant differences were found in hemolysin production. Thus, synanthropic migratory birds nesting in an urban area could be involved in the wide spread of yeast virulence. It seems very important to advocate that landfills in urban areas are nowadays closed and "relocated" to large distances from cities and that biowaste is treated before dumping in order to prevent and minimize its negative impact on the environment (water, soil, air) and human health.

100 Deals associated with Moscow State University Lomonosov

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100 Translational Medicine associated with Moscow State University Lomonosov

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Pipeline

Pipeline Snapshot as of 02 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

6

2

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

SRH-DR5-B-iRGD ( DR5 x VEGFR2 )	Glioblastoma More	Preclinical
K1-5	Neoplasms More	Preclinical
Plasminogen activators modulators(Moscow State University Lomonosov) ( Plasminogen activators )	Metabolic Syndrome More	Preclinical
BB-0322703 ( TRPM8 )	Pain More	Preclinical
BB 0322720 ( TRPM8 )	Pain More	Preclinical