[Translation] An open-label, multicenter Phase Ib/II clinical study evaluating the efficacy and safety of XS-03 in combination with FOLFOX or FOLFIRI and bevacizumab in patients with RAS-mutated metastatic colorectal cancer
评价XS-03与FOLFOX或FOLFIRI和贝伐珠单抗联合治疗RAS突变转移性结直肠癌患者的耐受性、安全性、药代动力学、药效学特征等,确定联合用药的RP2D,并初步评估XS-03联合方案治疗RAS突变转移性结直肠癌的有效性。
[Translation] To evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of XS-03 combined with FOLFOX or FOLFIRI and bevacizumab in the treatment of patients with RAS mutation metastatic colorectal cancer, determine the RP2D of the combination, and preliminarily evaluate the effectiveness of the XS-03 combination regimen in the treatment of RAS mutation metastatic colorectal cancer.