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Author: Das, Anupam ; Choudhury, Shuvasish ; Chowardhara, Bhaben ; Upadhyay, Munish Kumar ; Repalli, Sai Krishna ; Yadav, Poonam ; Pattnaik, Binaya Kumar ; Dhar, Anannya ; Majumdar, Arnab ; Saha, Bedabrata ; Hossain, Akbar ; Sarkar, Sukamal ; Dey, Saikat ; Majumdar, Jayjit ; Ghosh, Dibakar ; Moulick, Debojyoti ; Garai, Sourav ; Mandal, Sayanti ; Santra, Subhas Chandra ; Dash, Goutam Kumar

Abstract: Seed priming technol. (SP) is a practice (conducted prior to sowing) where seeds are treated with a wide range of seed priming agents (SPA) for a set time period followed by withdrawal.The efficacy of SP has been widely examined against various abiotic and biotic stressors with various crops in controlled field environmental conditions.Among the abiotic stressors, heavy metals and/or metalloids (HMs) are considered as a serious threat to sustainable agriculture.Compared with other stressors, the efficacy of SP in ameliorating HM-induced phytotoxicity and minimizing HMs content in edible parts are limited.However, there is a lack of a comprehensive study dedicated to HMs stress in wide range of crops.This review article employs a blend of bibliometric-based anal. (to assess global trends) followed by systematic evaluation of traditional (micronutrient, biomols., etc.) and nanomaterial (NMs)-based SPAs in ameliorating HMs-induced stress and accumulation in various crops.Our assessment suggests SPs as a suitable means to fill the vacuum that exists among the controlled environment and field condition, cost effective, easy remedial measure for HMs-induced stress.However, the need of in-depth (cellular and mol. level) as well as multi-location trials will definitely add to the current knowledge for development of effective HM stress resilience.

01 Aug 2025·Reproductive Toxicology

Co-administration of atorvastatin with piperine induces reproductive toxicity in male Wistar rats through oxidative stress induction and downregulation of StAR, CYP11a1, 3βHSD and 17βHSD genes

Article

Author: Biswas, Maharaj ; Ghosh, Sanjib

Atorvastatin is a statin group of medicine that inhibits biosynthesis of cholesterol and mainly prescribed for treating cardiovascular diseases. Black pepper is a one of the mostly used spices that contains an alkaloid called piperine in its fruits which is known to cause male reproductive toxicity. Both atorvastatin and black pepper (piperine) are randomly consumed by the patients of chronic hyperlipidemia and it is important to know the synergistic effects of atorvastatin and piperine on male fertility parameters. Twenty rats were taken for the study and divided into four groups each containing five rats. Group I served as a control, group II animals are treated with atorvastatin (ATR) (8mg/kg BW), group III animals received piperine (PIP) (10mg/kg BW) and group IV animals were co-administered with piperine (10mg/kg BW) and atorvastatin (8mg/kg BW). All treatments were done by using water suspension of atorvastatin and piperine and using oral gavage for consecutive 28 days and thereafter assessed for gravimetric and histomorphometry analysis, sperm motility and morphology, ROS generation, anti-oxidant enzymes, serum testosterone quantification, qRTPCR (StAR, CYP11a1, 3βHSD and 17βHSD genes) and toluidine blue staining for analyzing chromatin integrity of spermatozoa. The results showed that co-administration of ATR+PIP significantly reduced body weight, changed in GSI also found. Activities of major two antioxidant enzymes (SOD and Catalase) were found to reduce whereas levels of TBARS and ROS in testicular tissues increased significantly. The study found that combined administration of atorvastatin and piperine negatively impacted male fertility potential, causing reproductive toxicity.

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Pipeline

Pipeline Snapshot as of 14 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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